Publication Date:
2016-04-09
Description:
Various Mitsunobu conditions were investigated for a series of flavonolignans (silybin A, silybin B, isosilybin A, and silychristin A) to achieve either selective esterification in position C-23 or dehydration in a one-pot reaction yielding the biologically important enantiomers of hydnocarpin D, hydnocarpin and isohydnocarpin, respectively. This represents the only one-pot semi-synthetic method to access these flavonolignans in high yields. Beilstein J. Org. Chem. 2016, 12, 662–669. doi:10.3762/bjoc.12.66
Keywords:
dehydrationflavonoidhydnocarpinMitsunobusilybin
Electronic ISSN:
1860-5397
Topics:
Chemistry and Pharmacology
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