ALBERT

Description: Motivation: Molecular dynamics simulations provide atomic insight into the physicochemical characteristics of lipid membranes and hence, a wide range of force field families capable of modelling various lipid types have been developed in recent years. To model membranes in a biologically realistic lipid composition, simulation systems containing multiple different lipids must be assembled. Results: We present a new web service called MemGen that is capable of setting up simulation systems of heterogenous lipid membranes. MemGen is not restricted to certain lipid force fields or lipid types, but instead builds membranes from uploaded structure files which may contain any kind of amphiphilic molecule. MemGen works with any all-atom or united-atom lipid representation. Availability and implementation: MemGen is freely available without registration at http://memgen.uni-goettingen.de . Contact: jhub@gwdg.de Supplementary information: Supplementary data are available at Bioinformatics online.

Description: Numerous scholars have noted the disproportionately high number of gay and lesbian workers in certain occupations, but systematic explanations for this type of occupational segregation remain elusive. Drawing on the literatures on concealable stigma and stigma management, we develop a theoretical framework predicting that gay men and lesbians will concentrate in occupations that provide a high degree of task independence or require a high level of social perceptiveness, or both. Using several distinct measures of sexual orientation, and controlling for potential confounds, such as education, urban location, and regional and demographic differences, we find support for these predictions across two nationally representative surveys in the United States for the period 2008–2010. Gay men are more likely to be in female-majority occupations than are heterosexual men, and lesbians are more represented in male-majority occupations than are heterosexual women, but even after accounting for this tendency, common to both gay men and lesbians is a propensity to concentrate in occupations that provide task independence or require social perceptiveness, or both. This study offers a theory of occupational segregation on the basis of minority sexual orientation and holds implications for the literatures on stigma, occupations, and labor markets.

Description: Small- and wide-angle X-ray scattering (SWAXS) has evolved into a powerful tool to study biological macromolecules in solution. The interpretation of SWAXS curves requires their accurate predictions from structural models. Such predictions are complicated by scattering contributions from the hydration layer and by effects from thermal fluctuations. Here, we describe the new web server WAXSiS (WAXS in solvent) that computes SWAXS curves based on explicit-solvent all-atom molecular dynamics (MD) simulations ( http://waxsis.uni-goettingen.de/ ). The MD simulations provide a realistic model for both the hydration layer and the excluded solvent, thereby avoiding any solvent-related fitting parameters, while naturally accounting for thermal fluctuations.

Description: Saccharomyces sensu stricto complex consist of yeast species, which are not only important in the fermentation industry but are also model systems for genomic and ecological analysis. Here, we present the complete genome assemblies of Saccharomyces jurei , a newly discovered Saccharomyces sensu stricto species from high altitude oaks. Phylogenetic and phenotypic analysis revealed that S. jurei is more closely related to S. mikatae , than S. cerevisiae , and S. paradoxus . The karyotype of S. jurei presents two reciprocal chromosomal translocations between chromosome VI/VII and I/XIII when compared to the S. cerevisiae genome. Interestingly, while the rearrangement I/XIII is unique to S. jurei , the other is in common with S. mikatae strain IFO1815, suggesting shared evolutionary history of this species after the split between S. cerevisiae and S. mikatae . The number of Ty elements differed in the new species, with a higher number of Ty elements present in S. jurei than in S. cerevisiae . Phenotypically, the S. jurei strain NCYC 3962 has relatively higher fitness than the other strain NCYC 3947 T under most of the environmental stress conditions tested and showed remarkably increased fitness in higher concentration of acetic acid compared to the other sensu stricto species. Both strains were found to be better adapted to lower temperatures compared to S. cerevisiae .

Description: We homogeneously analyse ∼3.2 × 105 photometric measurements for ∼1100 transit light curves belonging to 17 exoplanet hosts. The photometric data cover 16 years (2004–2019) and include amateur and professional observations. Old archival light curves were reprocessed using up-to-date exoplanetary parameters and empirically debiased limb-darkening models. We also derive self-consistent transit and radial-velocity fits for 13 targets. We confirm the non-linear transit timing variation (TTV) trend in the WASP-12 data at a high significance, and with a consistent magnitude. However, Doppler data reveal hints of a radial acceleration of about −7.5 ± 2.2 m s−1 yr−1, indicating the presence of unseen distant companions, and suggesting that roughly 10 per cent of the observed TTV was induced via the light-travel (or Roemer) effect. For WASP-4, a similar TTV trend suspected after the recent TESS observations appears controversial and model dependent. It is not supported by our homogeneous TTV sample, including 10 ground-based EXPANSION light curves obtained in 2018 simultaneously with TESS. Even if the TTV trend itself does exist in WASP-4, its magnitude and tidal nature are uncertain. Doppler data cannot entirely rule out the Roemer effect induced by possible distant companions.

Description: As the increased distance between Earth-based mission control and the spacecraft results in increasing communication delays, small crews cannot take on all functions performed by ground today, and so vehicles must be more automated to reduce the crew workload for such missions. In addition, both near-term and future missions will feature significant periods when crew is not present, meaning the vehicles will need to operate themselves autonomously. NASA's Advanced Exploration Systems Program pioneers new approaches for rapidly developing prototype systems, demonstrating key capabilities, and validating operational concepts for future human missions beyond low-Earth orbit. Under this program, NASA has developed and demonstrated multiple technologies to enable the autonomous operation of a dormant space habitat. These technologies included a fault-tolerant avionics architecture, novel spacecraft power system and power system controller, and autonomy software to control the habitat. The demonstration involved simulation of the habitat and multiple spacecraft sub-systems (power storage and distribution, avionics, and air-side life-support) during a multi-day test at NASA's Johnson Space Center. The foundation of the demonstration was quiescent operations' of a habitat during a 55 minute eclipse period. For this demonstration, the spacecraft power distribution system and air-side life support system were simulated at a high level of fidelity; additional systems were managed, but with lower fidelity operational constraints and system behavior. Operational constraints for real and simulated loads were developed by analyzing on-orbit hardware and evaluating future Exploration capable technology. A total of 13 real and simulated loads were used during the test. Eight scenarios including both nominal and off-nominal conditions were performed. Over the course of the test, every application performed its desired functions successfully during the simulated tests. The results will inform both future tests, as well as provide insight to NASA's domestic and international partners, as they construct the next generation of space habitats to be used on beyond-Earth missions.