Publication Date:
2015-05-01
Description:
Article The protein p16 INK4a promotes senescence in tissue stem cells and thereby contributes to organismal ageing. Here the authors reveal that p16 INK4a also downregulates expression of a-klotho , thereby revealing an additional ageing-promoting function of 16 INK4a that is independent from its role in senescence. Nature Communications doi: 10.1038/ncomms8035 Authors: Seidai Sato, Yuka Kawamata, Akiko Takahashi, Yoshinori Imai, Aki Hanyu, Atsushi Okuma, Masaki Takasugi, Kimi Yamakoshi, Hiroyuki Sorimachi, Hiroaki Kanda, Yuichi Ishikawa, Saburo Sone, Yasuhiko Nishioka, Naoko Ohtani, Eiji Hara
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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