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  • 1
    Call number: AWI S5-18-91741
    Type of Medium: Monograph available for loan
    Pages: xcix, 2868 Seiten
    Edition: 10., vollständig überarbeitete und erweiterte Auflage
    ISBN: 9783452282750 (238.00 EUR)
    Series Statement: Heymanns Kommentare zum gewerblichen Rechtsschutz
    Language: German
    Location: AWI Reading room
    Branch Library: AWI Library
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Molecular genetics and genomics 52 (1929), S. 191-235 
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 1 (1929), S. 33-40 
    ISSN: 1432-2242
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied climatology 10 (1959), S. 164-164 
    ISSN: 1434-4483
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied climatology 9 (1958), S. 360-412 
    ISSN: 1434-4483
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Description / Table of Contents: Summary The temperature series of Basle hitherto studied back until 1826 has been extended to 1755 by means of the observations ofJ. J. d'Annone. The whole series is now reduced to the present position of the meteorological station at St. Margarethen near Basle, whereby also the increasing town effects have been taken into account. Methods for the reductions have been developed which enable a numerical analysis of the different sources of error. A comparison with other secular series leads to the conclusion that this Basle series of 1755–1957 represents a valuable completion of the hitherto existing Central European material, since it completes e. g. the triangle De Bilt—Berlin—Vienna used byF. Baur, to a quadrangle.
    Abstract: Résumé La série bâloise d'observations de température précédemment établie depuis 1826 a été prolongée en arrière jusqu'à l'année 1755 à l'aide des observations deJ. J. d'Annone. La série complète est maintenant réduite à l'atitude de la station actuelle de St. Margarethen, compte tenu de l'effet croissant de l'agglomération urbaine. Ces réductions furent faites par des méthodes permettant d'éliminer au mieux les différentes causes d'erreur. La série bâloise de température de 1755–1957 constitue dès lors un précieux document venant s'ajouter aux séries existantes de l'Europe centrale; elle fait, par exemple, du triangle De Bilt—Berlin—Vienne utilisé parF. Baur un quadrilatère de stations de base.
    Notes: Zusammenfassung Die Basler Temperaturreihe, bisher bis 1826 bearbeitet, wird mit Hilfe der Beobachtungen vonJ. J. d'Annone bis zum Jahre 1755 rückwärts erweitert. Dabei wird die ganze Reihe auf den jetzigen Standort der meteorologischen Station auf St. Margarethen reduziert, wobei auch der zunehmende Stadteinfluß berücksichtigt ist. Für die Reduktionen wurden Methoden entwickelt, die eine zahlenmäßige Erfassung der verschiedenen Fehlerquellen ermöglichen. Wie auch ein Vergleich mit anderen langjährigen Reihen zeigt, bildet diese Basler Reihe 1755 bis 1957 eine wertvolle Erweiterung der bisherigen mitteleuropäischen Reihen, indem sie z. B. das vonF. Baur benutzte Dreieck De Bilt—Berlin—Wien zu einem Viereck ergänzt.
    Type of Medium: Electronic Resource
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  • 6
    Publication Date: 2015-09-25
    Description: Background: There are no commercially available vaccines against human protozoan parasitic diseases, despite the success of vaccination-induced long-term protection against infectious diseases. East Coast fever, caused by the protist Theileria parva, kills one million cattle each year in sub-Saharan Africa, and contributes significantly to hunger and poverty in the region. A highly effective, live, multi-isolate vaccine against T. parva exists, but its component isolates have not been characterized. Here we sequence and compare the three component T. parva stocks within this vaccine, the Muguga Cocktail, namely Muguga, Kiambu5 and Serengeti-transformed, aiming to identify genomic features that contribute to vaccine efficacy. Results: We find that Serengeti-transformed, originally isolated from the wildlife carrier, the African Cape buffalo, is remarkably and unexpectedly similar to the Muguga isolate. The 420 detectable non-synonymous SNPs were distributed among only 53 genes, primarily subtelomeric antigens and antigenic families. The Kiambu5 isolate is considerably more divergent, with close to 40,000 SNPs relative to Muguga, including 〉8,500 non-synonymous mutations distributed among 〉1,700 (42.5 %) of the predicted genes. These genetic markers of the component stocks can be used to characterize the composition of new batches of the Muguga Cocktail. Conclusions: Differences among these three isolates, while extensive, represent only a small proportion of the genetic variation in the entire species. Given the efficacy of the Muguga Cocktail in inducing long-lasting protection against infections in the field, our results suggest that whole-organism vaccines against parasitic diseases can be highly efficacious despite considerable genome-wide differences relative to the isolates against which they protect.
    Electronic ISSN: 1471-2164
    Topics: Biology
    Published by BioMed Central
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  • 7
    Publication Date: 2016-05-12
    Description: Analytical Chemistry DOI: 10.1021/acs.analchem.6b00373
    Print ISSN: 0003-2700
    Electronic ISSN: 1520-6882
    Topics: Chemistry and Pharmacology
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  • 8
    Publication Date: 2015-10-13
    Description: Background: The genus Brachyspira currently encompasses seven valid species that colonize the intestines of mammals and birds. In a previous study a group of strongly haemolytic isolates from pigs and mallards was provisionally described as a new species within genus Brachyspira, “B. suanatina”, and enteropathogenic properties were demonstrated in a porcine challenge model. Methods: In the current study characterization of B. suanatina was performed on the basis of cell morphology, growth characteristics, enzyme profiles, DNA-DNA hybridization (DDH) and whole genome comparisons. The draft genome sequence of B. suanatina strain AN4859/03 was determined and compared with the available genomes of all valid species of Brachyspira. Results: According to morphological traits, growth characteristics and enzymatic profiles, B. suanatina was similar to the type strain of B. hyodysenteriae, but using the recommended threshold value of 70 % similarity by DDH it did not belong to any of the recognized Brachyspira species (range 16–64 % similarity). This was further supported by average nucleotide identity values. Phylogenetic analysis performed using housekeeping genes and core genomes of all valid Brachyspira sp. and “B. hampsonii” revealed that B. suanatina and B. intermedia formed a clade distinct from B. hyodysenteriae. By comparing the genomes of the three closely related species B. intermedia, B. hyodysenteriae and B. suanatina similar profiles of general genomic features and distribution of genes in different functional categories were obtained. However, the genome size of B. hyodysenteriae was smallest among the species, suggesting the possibility of reductive evolution in the divergence of this species. A bacteriophage region and a putative plasmid sequence were also found in the genome of B. suanatina strain AN4859/03. Conclusions: The results of our study suggest that despite being similar to B. hyodysenteriae phenotypically, B. suanatina should be regarded as a separate species based on its genetic characteristics. Based on characteristics presented in this report we propose that strains AN4859/03, AN1681:1/04, AN2384/04 and Dk12570-2 from pigs in Sweden and Denmark, and strains AN3949:2/02 and AN1418:2/01 isolated from mallards in Sweden, represent a unique species within genus Brachyspira. For this new species we propose the name B. suanatina for which the type strain is AN4859/03 T (=ATCC® BAA-2592™ = DSM 100974 T ).
    Electronic ISSN: 1471-2180
    Topics: Biology
    Published by BioMed Central
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  • 9
    Publication Date: 2018-04-24
    Description: Genes, Vol. 9, Pages 225: Genome-Guided Analysis of Clostridium ultunense and Comparative Genomics Reveal Different Strategies for Acetate Oxidation and Energy Conservation in Syntrophic Acetate-Oxidising Bacteria Genes doi: 10.3390/genes9040225 Authors: Shahid Manzoor Anna Schnürer Erik Bongcam-Rudloff Bettina Müller Syntrophic acetate oxidation operates close to the thermodynamic equilibrium and very little is known about the participating organisms and their metabolism. Clostridium ultunense is one of the most abundant syntrophic acetate-oxidising bacteria (SAOB) that are found in engineered biogas processes operating with high ammonia concentrations. It has been proven to oxidise acetate in cooperation with hydrogenotrophic methanogens. There is evidence that the Wood-Ljungdahl (WL) pathway plays an important role in acetate oxidation. In this study, we analysed the physiological and metabolic capacities of C. ultunense strain Esp and strain BST on genome scale and conducted a comparative study of all the known characterised SAOB, namely Syntrophaceticus schinkii, Thermacetogenium phaeum, Tepidanaerobacter acetatoxydans, and Pseudothermotoga lettingae. The results clearly indicated physiological robustness to be beneficial for anaerobic digestion environments and revealed unexpected metabolic diversity with respect to acetate oxidation and energy conservation systems. Unlike S. schinkii and Th. phaeum, C. ultunense clearly does not employ the oxidative WL pathway for acetate oxidation, as its genome (and that of P. lettingae) lack important key genes. In both of those species, a proton motive force is likely formed by chemical protons involving putative electron-bifurcating [Fe-Fe] hydrogenases rather than proton pumps. No genes encoding a respiratory Ech (energy-converting hydrogenase), as involved in energy conservation in Th. phaeum and S. schinkii, were identified in C. ultunense and P. lettingae. Moreover, two respiratory complexes sharing similarities to the proton-translocating ferredoxin:NAD+ oxidoreductase (Rnf) and the Na+ pumping NADH:quinone hydrogenase (NQR) were predicted. These might form a respiratory chain that is involved in the reduction of electron acceptors rather than protons. However, involvement of these complexes in acetate oxidation in C. ultunense and P. lettingae needs further study. This genome-based comparison provides a solid platform for future meta-proteomics and meta-transcriptomics studies and for metabolic engineering, control, and monitoring of SAOB.
    Electronic ISSN: 2073-4425
    Topics: Biology
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  • 10
    Publication Date: 2019
    Description: Abstract A pronounced warm anomaly occurred at the Peruvian coast in early 2017. This “Coastal Niño” caused heavy rainfalls, leading to flooding in Peru and Ecuador. At the same time, neutral conditions prevailed in the equatorial Pacific. Using observational sea surface temperature (SST) data sets and an ocean reanalysis product for the time period 1900 to 2010, previous similar events are investigated. Eighteen coastal warming events without corresponding equatorial Pacific warming are identified. Further analysis shows, however, that only four of these events are not connected to the central equatorial Pacific. All other periods of strong coastal warm anomalies are directly followed or preceded by El Niño‐like conditions. The “stand alone” coastal warming events are characterized by comparatively low equatorial heat content. We thus hypothesize that the depleted heat content in the equatorial Pacific in the wake of the strong 2015/16 El Niño prevented the warming to spread westward in 2017.
    Print ISSN: 0094-8276
    Electronic ISSN: 1944-8007
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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