Publication Date:
2018-01-13
Description:
20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1 20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1, Published online: 12 January 2018; doi:10.1038/s41467-017-02539-4 FFAR1 receptor is highly expressed in beta cells and its activation has been suggested as therapy against type-2 diabetes. Here, Tunaru et al. show that 20-hydroxyeicosatetraenoic acid, produced within the islets upon glucose stimulation, acts in an autocrine manner to stimulate insulin secretion via FFAR1 activation.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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