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  • 2020-2024  (33)
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  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Zoology. ; Neurochemistry. ; Neuroscience. ; Zoology. ; Neurochemistry.
    Description / Table of Contents: 1. Introduction to the complexity of cell surface and tissue matrix glycoconjugates. -- 2. Introduction to cells comprising the nervous system. -- 3. Synthesis -- processing -- and function of N-glycans in N-glycoproteins. -- 4. Synthesis of O-linked glycoconjugates in the nervous system. -- 5. Chemistry and function of glycosaminoglycans in the nervous system. -- 6. Use of glycan-targeted antibodies/lectins to study the expression/function of glycosyltransferases in the nervous system. -- 7. Capillary electrophoresis and mass spectrometry-based glycosylation analysis in glycomics and glycoproteomics. -- 8. Structural analysis of oligosaccharides and glycoconjugates using NMR. -- 9. Glycolipid and glycoprotein expression during neural development. -- 10. Gangliosides and cell surface ganglioside glycohydrolases in the nervous system (request them to include gal-cer and sulfatide). -- 11. Role of myelin-associated glycoproteins in the peripheral nervous system. -- 12. Glycosignaling: a general review. -- 13. Glycosphingolipids in the regulation of the nervous system. -- 14. O-GlcNAcylation of neuronal proteins: Roles in neuronal functions and in neurodegeneration. -- 15. Glycoconjugates in nuclear membranes. -- 16. N-glycosylation in regulation of the nervous system. -- 17. Role of carbohydrates in the interaction of pathogens with neural cells. -- 18. Glycoconjugate changes in aging and age-related diseases. -- 19. Gangliosides and glycolipids in neurodegenerative disorders. -- 20. Inborn errors of glycosphingolipid catabolism and potential treatment. -- 21. Neurological aspects of human glycosylation disorders. -- 22. Glycoconjugates and neural tumors. -- 23. Galectins and neuroinflammation . -- 24. Glycoconjugates and neuroimmunological diseases. -- 25. Targeting nanoparticle drug carriers to the brain. -- 26. Use of quantum dots to treat inherited lysosomal storage diseases. -- 27. MALDI-FTICR MS imaging of nervous system glycoconjugates.
    Abstract: This new edition provides comprehensive coverage of the variety and complexity of the roles that glycoconjugates play in the cells of the nervous system. Basic fundamental principles as well as the latest developments in neural glycobiology are discussed. Topics covered range from the structure and metabolism of the saccharide chains and current approaches used in their study, to changes glycoconjugates undergo during development and aging of the nervous system and the roles they have in neurological disease. New topics include a detailed discussion of cells found within the nervous system, an extensive listing of congenital disorders of glycosylation of both proteins and lipids, the roles of glycans in neuronal axon growth/guidance and voltage-gated channels, the role of intra-lysosomal luminal vesicles in lysosomal storage disorders, and, in the time of the COVID-19 pandemic, the role of carbohydrates in infection by SARS-CoV-2. The breadth and depth of topics covered make this an essential reference for those new to the field as well as for more experienced investigators.
    Type of Medium: Online Resource
    Pages: XII, 501 p. 96 illus., 73 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031123900
    Series Statement: Advances in Neurobiology, 29
    DDC: 612.8
    Language: English
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  • 2
    Publication Date: 2024-03-30
    Description: Sowohl in der wissenschaftlichen als auch in der öffentlichen Diskussion stehen Fragen der Umgestaltung des Bildungswesens ganz oben auf der Tagesordnung. Das hat vielfältige Ursachen. Diese gründen sich nicht nur auf den klassischen Zielkonflikt zwischen Effizienz und Gerechtigkeit, sondern reflektieren auch Folgewirkungen des technischen Fortschritts sowie die zunehmende Internationalisierung der Bildungssysteme. Die in der Bundesrepublik Deutschland stattfindende Reformdiskussion folgt damit einem Anpassungszwang des "Marktes für Humankapital" an die Gegebenheiten des wirtschaftlichen Wettbewerbs innerhalb und zwischen hochentwickelten Industrieländern. Mit welchem Ziel und auf welche Weise sollte das Bildungssystem verändert werden? Offensichtlich haben gesamtwirtschaftliche und institutioneninterne Effizienzziele eine hohe Priorität. Mögliche Wege dorthin berühren in zentraler Weise die Themen Deregulierung und Finanzierung. Es ist ein Anliegen dieses Bandes, die bildungsökonomische Rolle des Staates vor diesem Hintergrund auf den Ebenen der Schule, des Dualen Systems, der Hochschule und der Weiterbildung in einigen aktuellen Ausschnitten neu zu beleuchten.
    Keywords: GE1-350 ; Schule ; Bildungsreform ; Bildungsfinanzierung ; Sozialpolitik ; Deregulierung ; Bildungspolitik ; Berufsausbildung ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCV Economics of specific sectors::KCVG Environmental economics
    Language: German
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  • 3
    Publication Date: 2023-12-21
    Description: Not only developed countries, but also most developing areas of the world, have experienced a surge in obesity prevalence over recent decades. Obesity complications are now among the leading causes of premature mortality, encompassing conditions such as coronary heart disease, stroke, and type 2 diabetes. This places a heavy burden on contemporary healthcare systems. While rodent models have limitations as experimental models of human obesity-related disease, study of rats and mice either spontaneously prone - or resistant - to obesity, or genetically engineered to illuminate underlying mechanisms has yielded key information about the metabolic defects linked to obesity, and their associated diseases. This topic includes both original research studies and reviews of the use of animal studies in specific areas of obesity-related disease. Various methodological approaches are discussed, with evaluation of the extent to which use of animal models has facilitated progress, or, conversely, has proved a cul de sac in investigation of human disease mechanisms. Consideration is also given to future strategies to use such rodent models optimally to enhance comprehension and treatment of pandemic human obesity-related diseases.
    Keywords: R5-920 ; RC648-665 ; TX341-641 ; Obesity ; disease ; non-alcoholic fatty liver disease ; rodent models ; type 2 diabetes mellitus ; bic Book Industry Communication::M Medicine
    Language: English
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  • 4
    Publication Date: 2023-09-09
    Description: This dataset contains single-shell stable isotope data (d18O and d13C), shell weights, ages, and preservation states of Cibicidoides shells spanning MIS 1-2 from ODP Site 929, Ceara Rise (5.976°N, -43.740°E, 4357 m water depth). Sediment samples were processed following standard procedures. From each 〉63µm sediment sample, all specimens of the genera Cibicidoides and Uvigerina were picked from the 〉150 µm size fraction. Using a binocular microscope, each individual Cibicidoides and Uvigerina specimen was critically evaluated for preservation quality. Details of the Foraminiferal Preservation Index (FPI) can be found in the corresponding publication. In short, an initial score (IS) of 5 is applied to an ideal specimen with clearly defined whorls, sutures, pores, and other surface features. A shell with an IS score of 3 usually contains enlarged pores and "smoothed" looking surface features, including sutures and surface ornamentation. An IS score of 4 is assigned to specimens with more subtly smoothed features, and/or slightly enlarged pores. From the IS3-5 value for a given specimen, deductions of 1-2 points are applied to generate its final score (FS). A deduction of 1 point is applied for either a missing or fractured chamber, and/or evidence of slight dissolution. A deduction of 2 points is applied for extensive missing or fractured chambers, and/or evidence of extensive dissolution. For example, an assigned FS1 value for a specimen could be the result of highly smoothed surface features, with some combination of extensive dissolution pockmarks and/or one to several fractured/missing chambers (i.e. IS3 - 2 = FS1). The letter "A" assigned to the final score indicates that the appearance of the shell is glassy, "B" is assigned to pseudo-glassy shells, and "C" to frosty specimens. Specimens of varying preservation quality were purposely chosen for single-shell stable isotope analyses. Each specimen was weighed, and shells featuring narrow mass ranges were selected for individual analytical runs of d18O and d13C which allows for the optimization of instrument tuning. Single Cibicidoides shells were analyzed on a Thermo Delta V Kiel IV dual inlet mass spectrometer at the Lamont-Doherty Earth Observatory, and were corrected relative to the NBS-19 calcite standard. Average precision on these analyses was better than 0.08‰ for δ18O and better than 0.06‰ for δ13C. The age model is based on published stable isotope records (Bickert et al., 1997; Billups et al., 1998) tuned to the deep sea benthic d18O stack (Lisiecki and Raymo, 2005; Ahn et al., 2017).
    Keywords: 154-929B; AGE; Cibicidoides; Cibicidoides spp., δ13C; Cibicidoides spp., δ18O; d13C; d18O; DRILL; Drilling/drill rig; DSDP/ODP/IODP sample designation; Foraminifera, preservation index; Joides Resolution; Leg154; Marine isotope stage; Mass; ODP Site 929; preservation; Sample code/label; see description in data abstract; single-shell; South Atlantic Ocean; Stable isotopes; Thermo Delta V Kiel IV dual inlet mass spectrometer; Weighted
    Type: Dataset
    Format: text/tab-separated-values, 1032 data points
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  • 5
    Publication Date: 2023-08-26
    Description: The oxygen isotopic composition of benthic foraminifera (d18Ob) is widely used to date and correlate marine sediment sequences. However, d18Ob has found comparatively little use in the Arctic Ocean due both to uncertainty in Arctic marine sediment chronology and the lack of resemblance between Arctic and open ocean d18Ob records. We address this issue by combining Arctic d18Ob records (Cronin et al., 2019) with benthic ostracode Mg/Ca-BWT reconstructions (Cronin et al., 2017) to create a composite record of the history of seawater d18O in the intermediate-to-deep Arctic Ocean over the last 600 kyr. Seawater d18O and its uncertainty was calculated using PSU Solver (Thirumalai et al., 2016).
    Keywords: AGE; Arctic_Ocean_Section_1994; Arctic_Summer_West_1992; Arctic Ocean; B16; B17; B8; BC; benthic foraminiferal stable isotopes; Bottom water temperature; Box corer; Calculated; calculated, 1 sigma; Cassidulina teretis, δ18O; Cibicidoides wuellerstorfi, δ18O; Cibicidoides wuellerstorfi, δ18O standard deviation; DEPTH, sediment/rock; Elevation of event; Event label; Healy; Healy-Oden Trans Arctic Expedition 2005 (HOTRAX05); HLY0503; HLY0503-18TC; interpolated; Latitude of event; Lomonosov Ridge, Arctic Ocean; Longitude of event; Magnesium/Calcium ratio; Mendeleev Ridge; Mg/Ca paleothermometry; Normalized to Cibicidoides wuellerstorfi; Normalized to Uvigerina; Northwind Ridge; Oridorsalis tener, δ18O; ostracodes; oxygen isotope data; P15; P192-AR-P30; P192-AR-P40; P1-93-AR; P193-AR-P21; P194AR-B16; P194-AR-B17; P194-AR-B8; P194-AR-P15; P194-AR-P9; P21; P30; P40; P9; PC; Piston corer; Polar Sea; Polar Star; Seawater δ18O; TC; Trigger corer; δ18O, seawater, reconstructed
    Type: Dataset
    Format: text/tab-separated-values, 4519 data points
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  • 6
    Publication Date: 2023-09-09
    Description: This dataset contains single-shell stable isotope data (d18O and d13C), shell weights, ages, and preservation states of Cibicidoides shells spanning MIS 9-10 from ODP Site 1089 north of Agulhas Ridge (-40.936°N, 9.894°E, 4620 m water depth). Sediment samples were processed following standard procedures. From each 〉63µm sediment sample, all specimens of the genera Cibicidoides and Uvigerina were picked from the 〉150 µm size fraction. Using a binocular microscope, each individual Cibicidoides and Uvigerina specimen was critically evaluated for preservation quality. Details of the Foraminiferal Preservation Index (FPI) can be found in the corresponding publication. In short, an initial score (IS) of 5 is applied to an ideal specimen with clearly defined whorls, sutures, pores, and other surface features. A shell with an IS score of 3 usually contains enlarged pores and “smoothed” looking surface features, including sutures and surface ornamentation. An IS score of 4 is assigned to specimens with more subtly smoothed features, and/or slightly enlarged pores. From the IS3-5 value for a given specimen, deductions of 1-2 points are applied to generate its final score (FS). A deduction of 1 point is applied for either a missing or fractured chamber, and/or evidence of slight dissolution. A deduction of 2 points is applied for extensive missing or fractured chambers, and/or evidence of extensive dissolution. For example, an assigned FS1 value for a specimen could be the result of highly smoothed surface features, with some combination of extensive dissolution pockmarks and/or one to several fractured/missing chambers (i.e. IS3 – 2 = FS1). The letter “A” assigned to the final score indicates that the appearance of the shell is glassy, “B” is assigned to pseudo-glassy shells, and “C” to frosty specimens. Specimens of varying preservation quality were purposely chosen for single-shell stable isotope analyses. Each specimen was weighed, and shells featuring narrow mass ranges were selected for individual analytical runs of d18O and d13C which allows for the optimization of instrument tuning. Single Cibicidoides shells were analyzed on a Thermo Delta V Kiel IV dual inlet mass spectrometer at the Lamont-Doherty Earth Observatory, and were corrected relative to the NBS-19 calcite standard. Average precision on these analyses was better than 0.08‰ for δ18O and better than 0.06‰ for δ13C. The age model is based on the published stable isotope record (Hodell et al. 2001) tuned to the deep sea benthic d18O stack (Lisiecki and Raymo, 2005; Ahn et al., 2017).
    Keywords: 177-1089C; 177-1089D; AGE; Cibicidoides; Cibicidoides spp., δ13C; Cibicidoides spp., δ18O; d13C; d18O; Date/Time of event; DRILL; Drilling/drill rig; DSDP/ODP/IODP sample designation; Elevation of event; Event label; Foraminifera, preservation index; Joides Resolution; Latitude of event; Leg177; Longitude of event; Marine isotope stage; Mass; ODP Site 1089; preservation; Sample code/label; see description in data abstract; single-shell; South Atlantic Ocean; Stable isotopes; Thermo Delta V Kiel IV dual inlet mass spectrometer; Weighted
    Type: Dataset
    Format: text/tab-separated-values, 654 data points
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  • 7
    Publication Date: 2023-12-12
    Description: Calibrated ages of a high-resolution peat core from the Past Global Changes - Carbon in Peat on EArth through Time (PAGES_C-PEAT) Project.
    Keywords: Age, 14C calibrated, Bacon 2.2 (Blaauw and Christen, 2011); Age, 14C calibrated, OxCal 4.2.4, P sequence deposition model; Calendar age; Calendar age, maximum/old; Calendar age, minimum/young; C-PEAT; DEPTH, sediment/rock; PAGES_C-PEAT; Past Global Changes - Carbon in Peat on EArth through Time; PEATC; Peat corer; Peatland; PL; Point_Lena_peatland; USA
    Type: Dataset
    Format: text/tab-separated-values, 546 data points
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  • 8
    Publication Date: 2023-12-12
    Description: 14C and 210Pb age determination of a high-resolution peat core from the Past Global Changes - Carbon in Peat on EArth through Time (PAGES_C-PEAT) Project.
    Keywords: Age; Age, 14C uncalibrated; Age, 210Pb; Age, dated; Age, dated material; Age, uncertainty; Burns_Bog; calculated, 1 sigma; Calendar age; Canada; Comment; C-PEAT; DEPTH, sediment/rock; Laboratory code/label; PAGES_C-PEAT; Past Global Changes - Carbon in Peat on EArth through Time; PEATC; Peat corer; Peatland; Sample thickness
    Type: Dataset
    Format: text/tab-separated-values, 127 data points
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  • 9
    Publication Date: 2023-12-12
    Description: Geochemistry data of a high-resolution peat core from the Past Global Changes - Carbon in Peat on EArth through Time (PAGES_C-PEAT) Project.
    Keywords: Carbon; Computed/Converted; C-PEAT; Density, dry bulk; DEPTH, sediment/rock; FC; Fish_Creek; Loss on ignition; PAGES_C-PEAT; Past Global Changes - Carbon in Peat on EArth through Time; PEATC; Peat corer; Peatland; Sample thickness; USA
    Type: Dataset
    Format: text/tab-separated-values, 288 data points
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  • 10
    Publication Date: 2023-12-12
    Description: Geochemistry data of a high-resolution peat core from the Past Global Changes - Carbon in Peat on EArth through Time (PAGES_C-PEAT) Project.
    Keywords: Canada; Carbon; Computed/Converted; C-PEAT; Density, dry bulk; DEPTH, sediment/rock; Loss on ignition; PAGES_C-PEAT; Past Global Changes - Carbon in Peat on EArth through Time; PEATC; Peat corer; Peatland; Sample thickness; SUR; Surrey_Bog
    Type: Dataset
    Format: text/tab-separated-values, 668 data points
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