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  • 1
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    Molecular Pharmacology and Pathology of Strokes (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
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    Publication Date: 2023-12-21
    Description: Stroke, a progressively non-communicable disease, is the second leading cause of death after coronary heart disease in developed countries. The present treatment options for stroke are adapting lifestyle practices, diabetes treatment, drugs, and the management of other factors, but no cure is yet available, despite new insights into molecular and therapeutic targets. Discoveries related to explicating the molecular pharmacology in cerebrovascular function and thrombosis have led to significant advancements in the current treatment paradigm for patients with stroke. Hence, this Special Issue invited scientific papers and reviews from researchers to provide solid evidence from a molecular point of view to scrutinize the molecular pharmacology and pathology of strokes. Platelet activation plays a major role in cardio and cerebrovascular diseases. Platelets also play a key role in the hemostatic process and are associated with various pathological events, such as arterial thrombosis and atherosclerosis. While the currently used anti-platelet drugs such as aspirin and clopidogrel demonstrate efficacy in many patients, they exert undesirable side effects. Therefore, the development of effective therapeutic strategies for the prevention and treatment of thrombotic diseases is a significant priority. Recently, precious metal drugs have conquered the subject of metal-based drugs, and several investigators have moved their attention to the synthesis of various ruthenium (Ru) and iridium (Ir) complexes due to their prospective therapeutic values. We have published this e-book about the “Molecular Pharmacology and Pathology of Strokes” and anticipate that readers will find this book useful regarding the significant challenges and current advances that are presently being made in stroke research, with the possibility of inspiring the application of novel drug development to enrich the devotion and treatment of patients with cardiovascular diseases.
    Keywords: R5-920 ; RM1-950 ; RC666-701 ; Neuroprotection ; Vascular diseases ; Novel drug development ; Signal transductions ; Clinical and translational research ; Free radicals/oxidative stress ; Platelet activation and thrombosis ; bic Book Industry Communication::M Medicine
    Language: English
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    E-BOOK
  • 2
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    Casual empiricism or uncovered optimality: an unsettled journey from theories and models in hydrological sciences (2023)
    In:  XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)
    Details
    Publication Date: 2023-06-27
    Description: Hydrology has been a subject of great relevance for human development, and its main object of study — the water — demands practical and short-term solutions to meet society's needs. One of the strongest foundations of hydrology is in hydraulics, where the conditions of laboratory experiments are highly controlled and robust equations are derived. These circumstances have contributed and influenced to the establishment of empirical relationships between the movement of water through landscapes and the conservation of mass law in catchments. However, analyses have revealed that some of the empirical relationships in catchments might also reflect a potential ecosystem's coevolution with climate, pushing catchments to optimise their supply and demand limits. This agrees with the eco-evolutionary optimality principles used in vegetation modelling. These principles are based on the hypothesis such as that canopy conductance acclimates to environmental variations on different temporal scales by balancing the costs of carbon assimilation and maintenance of transpiration rates. Here, we navigate through some established findings in hydrology that are still widely discussed. We also show the results of interfaces between simple models and approaches based on optimality and hydrology. Our examples are based on the application of the P-model and SPLASH, both calibration-free models that use remote sensing data. P-model is a vegetation model that uses the least-cost and coordination hypotheses to quantify gross primary productivity, which is then used to estimate transpiration. SPLASH is a parsimonious, multi-purpose set of algorithms designed for eco-hydrological applications, which include some principles from TOPMODEL for runoff partitioning.
    Language: English
    Type: info:eu-repo/semantics/conferenceObject
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    PAPER (OA)
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