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  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cancer Treatment. ; Tumor markers. ; Cancer Biology. ; Cancer Therapy. ; Tumour Biomarkers.
    Description / Table of Contents: Part 1. CTC Technologies -- Affinity -- Physical -- ctDNA -- miRNA -- Exosomes -- Part 2 -- Biology of CTC -- Dormancy -- Culture -- EMT -- ctDNA and Exosomes -- Cells in circulation with CTC -- Part 3 -- CTC Analysis -- IHC, FISH, and other molecular assays -- Functional characterization -- Advanced microscopy and AI -- Analysis of non-cellular circulating markers -- Part 4 -- Clinical Applications of the Liquid Biopsy -- Early detection and cancer screening -- Prognosis and therapeutic monitoring -- Applications in Clinical Trials -- Applications in Drug Development.
    Abstract: It is well recognized that blood could be the optimal site for evaluating cancer, allowing easy and repeated access for determining prognosis, establishing molecular targets, evaluating the efficacy of therapy, detecting the earliest signs of recurrence, and even detecting cancer at its earliest and most curable stages. The analysis of cancer through blood samples is now known as the liquid biopsy and has been a rich source of research and clinical application. There has been an explosion of interest and progress in liquid biopsy technologies since the first edition of this book. The second edition will expand its focus to now include not only circulating tumor cells (CTC), but also other emerging aspects of the liquid biopsy, including circulating tumor DNA and methylated DNA (ctDNA, ct meDNA), ctRNA, ct miRNA, circulating tumor proteins (and other) biomarkers and circulating tumor derived exosomes (ctExosomes).
    Type of Medium: Online Resource
    Pages: XXI, 668 p. 77 illus., 72 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031229039
    Series Statement: Current Cancer Research,
    DDC: 571.978
    Language: English
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  • 2
    Publication Date: 2023-11-24
    Description: This study investigates the impact of increased global warming on heat stress changes and the potential number of people exposed to heat risks over Africa. For this purpose a heat index has been computed based on an ensemble‐mean of high‐resolution regional climate model simulations from the Coordinated Output for Regional Evaluations embedded in the COordinated Regional Climate Downscaling EXperiment, under two Representative Concentration Pathways (RCPs) scenarios (RCP2.6 and RCP8.5), combined with projections of population growth developed based on the Shared Socioeconomic Pathways (SSPs) scenarios (SSP1 and SSP5). Results show that by the late 21st century, the increased global warming is expected to induce a 12‐fold increase in the area extent affected by heat stress of high‐risk level. This would result in an increase of about 10%–30% in the number of days with high‐risk heat conditions, as well as about 6%–20% in their magnitude throughout the seasonal cycle over West, Central, and North‐East Africa. Therefore, and because of the lack of adaptation and mitigation policies, the exacerbation of ambient heat conditions could contribute to the exposure of about 2–8.5 million person‐events to heat stress of high‐risk level over Burkina Faso, Ghana, Niger, and Nigeria. Furthermore, it was found that the interaction effect between the climate change and population growth seems to be the most dominant in explaining the total changes in exposure due to moderate and high heat‐related risks over all subregions of the African continent.
    Description: Plain Language Summary: This study investigates the impact of increased global warming on heat stress changes and the potential number of persons likely to be exposed to heat risks over Africa. Results show that by the end of the 21st century, the increased global warming is expected to induce a 12‐fold increase in the total area affected by dangerous heat conditions over the continent. This would result in an increase of about 10%–30% in the number of days with these heat conditions, as well as about 6%–20% in their magnitude throughout the seasonal cycle over West, Central and North‐East Africa. Therefore, because of the lack of adaptation and mitigation policies, the exacerbation of ambient heat conditions could contribute to the exposure of about 2–8.5 million person‐events to heat stress of high‐risk level over Burkina Faso, Ghana, Niger, and Nigeria. Since these heat events would be partly driven by interactions effects between climate change and population growth, efficient measures allowing not only to mitigate the increased greenhouse gas emissions, but also the effects of high heat on the human body must be urgently implemented on the affected countries' scale, in order to significantly decrease the vulnerability of their populations to potential heat‐related health problems.
    Description: Key Points: Increased global warming induces more spatially and temporally widespread extreme heat events over West, Central and North‐East Africa. Populations of some West African countries are projected to be particularly exposed to moderate and high heat conditions. Change in population exposure to dangerous heat categories is mainly driven by the interaction effect between climate and population growth.
    Description: Deutscher Akademischer Austauschdienst http://dx.doi.org/10.13039/501100001655
    Description: Projekt DEAL
    Description: https://esg-dn1.nsc.liu.se/search/cordex/
    Description: https://esgf-data.dkrz.de/projects/esgf-dkrz/
    Description: https://www.isimip.org/gettingstarted/details/31
    Description: https://sedac.ciesin.columbia.edu/data/set/popdynamics-1-8th-pop-base-year-projection-ssp-2000-2100-rev01/data-download
    Description: https://cds.climate.copernicus.eu/cdsapp#!/dataset/reanalysis-era5-single-levels?tab=form
    Keywords: ddc:551.6 ; Africa ; climate change ; heat stress index ; global warming
    Language: English
    Type: doc-type:article
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  • 3
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    Les Presses de l’Université d’Ottawa | University of Ottawa Press
    Publication Date: 2024-04-08
    Description: By their nature, emerging religions explore unfamiliar territory and probe unchartered regions of human creativity. For these same reasons, religious transactions that venture beyond the boundaries of traditional religious frontiers often rouse suspicion, anxiety or even fear among the general population. As new religious movements seek to carve out their own niche in society, public controversy and opposing beliefs can spark bitter debates, and can even lead to calls for state intervention. How then do new or borderline religious groups negotiate or mediate the building of public space? What impact can the media have on new religions? How does the law withstand the “creative destruction” of religious innovation? In this provocative collection of essays, twelve experienced specialists break new ground in the sociological study of religion.
    Keywords: BL1-50 ; Canada ; cult ; liberty ; sociology ; secularity ; religion ; bic Book Industry Communication::H Humanities::HR Religion & beliefs ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs
    Language: English
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  • 4
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    University of Ottawa Press / Les Presses de l’Université d’Ottawa
    Publication Date: 2024-04-08
    Description: religion - modernity
    Description: Originale, insolite, renaissante, l’action religieuse émergente bouscule les habitudes, ébranle les certitudes, construit ici, maintenant, l’autre monde. Peut-on courir le risque ? Voilà que la question se pose et se résout en rumeurs publiques, poursuites judiciaires et tensions scolaires, lesquelles mettent à nu des mécanismes inédits d’institutionnalisation de l’expérience religieuse en modernité : groupes tactiques d’intervention, cellules gouvernementales de crise, commissions parlementaires, cercles technocratiques précurseurs d’une ingénierie pluraliste. Sur fond de traditions religieuses, nationales ou républicaines, avec la perspective de la menace sectaire, s’esquisse sous nos yeux un religieux correct, acceptable. Comment est-il possible aujourd’hui d’inscrire l’exceptionnel, l’originel, le merveilleux, le transcendant religieux dans le quotidienne ? Et dans quelle mesure, paradoxalement, les gestionnaires de dieux ne repoussent-ils pas toujours plus loin la frontière religieuse ? -- By their nature, emerging religions explore unfamiliar territory and probe unchartered regions of human creativity. For these same reasons, religious transactions that venture beyond the boundaries of traditional religious frontiers often rouse suspicion, anxiety or even fear among the general population. As new religious movements seek to carve out their own niche in society, public controversy and opposing beliefs can spark bitter debates, and can even lead to calls for state intervention. How then do new or borderline religious groups negotiate or mediate the building of public space? What impact can the media have on new religions? How does the law withstand the “creative destruction” of religious innovation? In this provocative collection of essays, twelve experienced specialists break new ground in the sociological study of religion.
    Keywords: modernity ; modernité ; religion ; bic Book Industry Communication::H Humanities::HR Religion & beliefs::HRA Religion: general::HRAC Comparative religion ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRA Religion: general::QRAC Comparative religion
    Language: French
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  • 5
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: Repetitive DNA is ubiquitous in eukaryotic genomes, and, in many species, comprises the bulk of the genome. Repeats include transposable elements that can self-mobilize and disperse around the genome, and tandemly-repeated satellite DNAs that increase in copy number due to replication slippage and unequal crossing over. Despite their abundance, repetitive DNA is often ignored in genomic studies due to technical challenges in their identification, assembly, and quantification. New technologies and methods are now providing the unprecedented power to analyze repetitive DNAs across diverse taxa. Repetitive DNA is of particular interest because it can represent distinct modes of genome evolution. Some repetitive DNA forms essential genome structures, such as telomeres and centromeres, which are required for proper chromosome maintenance and segregation, whereas others form piRNA clusters that regulate transposable elements; thus, these elements are expected to evolve under purifying selection. In contrast, other repeats evolve selfishly and produce genetic conflicts with their host species that drive adaptive evolution of host defense systems. However, the majority of repeats likely accumulate in eukaryotes in the absence of selection due to mechanisms of transposition and unequal crossing over. Even these neutral repeats may indirectly influence genome evolution as they reach high abundance. In this Special Issue, the contributing authors explore these questions from a range of perspectives.
    Keywords: QH426-470 ; QH301-705.5 ; Q1-390 ; transgene ; zebra finch ; transcription ; endogenous retrovirus ; transposable element ; centromere drive ; arthropods ; PSR (Paternal sex ratio) ; Alu ; gene evolution ; nuclear rDNA ; epigenetics ; heterochromatin ; alpha satellite ; Su(Hw) ; repeated elements ; karyotype ; piRNA cluster ; gene duplication ; super-Mendelian ; estrildidae ; genomic conflict ; GC-content ; segregation ; CENP-A ; drift ; germline ; hobo ; I element ; repetitive DNA ; transposons ; human satellites ; retrotransposons ; genome assembly ; LTR retrotransposons ; satellite DNA ; structural variation ; selection ; host genome ; Uraeginthus cyanocephalus ; LINE-1 ; B chromosomes ; ERV ; arms race ; sequence variation ; secondary structure ; HeT-A and TART telomeric retrotransposons ; database ; genetic conflict ; coevolution ; ncRNAs (non coding RNAs) ; repeat ; centromeric transcription ; nucleolus ; satellite ; insulator ; Rhino ; population genetics ; centromere ; genome annotation ; horizontal transfer ; rRNA ; genome elimination ; genome evolution ; evolution ; chromosome evolution ; genome size ; genome ; drosophila ; transposable elements ; selfish elements ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical)
    Language: English
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  • 6
    Publication Date: 2024-03-24
    Description: Traditional dialects have been encroached upon by the increasing mobility of their speakers and by the onslaught of national languages in education and mass media. Typically, older dialects are “leveling” to become more like national languages. This is regrettable when the last articulate traces of a culture are lost, but it also promotes a complex dynamics of interaction as speakers shift from dialect to standard and to intermediate compromises between the two in their forms of speech. Varieties of speech thus live on in modern communities, where they still function to mark provenance, but increasingly cultural and social provenance as opposed to pure geography. They arise at times from the need to function throughout the different groups in society, but they also may have roots in immigrants’ speech, and just as certainly from the ineluctable dynamics of groups wishing to express their identity to themselves and to the world.
    Keywords: dialectology ; dialects ; Isogloss ; Standard language ; Syntax ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: English
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  • 7
    Publication Date: 2024-04-01
    Description: The Anthropocene – the era of humans – refers to a time when humanity has left its indelible stamp on the planet, including its geology and biogeochemistry. Understanding the Anthropocene, where the risk of irreversible and catastrophic ecological damage looms on the horizon, is a daunting task and solutions seem to be difficult to come by. What we offer in this book consists of fifteen perspectives on the Anthropocene written by scholars with backgrounds in over a dozen academic disciplines – archaeology, biology, geology, cultural history, literature, art history, science and technology studies, anthropology, political ecology, geography and law. Together, they offer tools enabling us to grasp the Anthropocene as a multifaceted phenomenon that requires attention from across the social and natural sciences as well as the humanities. Unlike most academic texts, these chapters are written in a personal and engaging style indicating not only that the Anthropocene is a worthy subject of scholarly attention, but that its implications are existentially important to the authors, who are not just researchers, but also global citizens.
    Description: Published
    Keywords: Anthropocene, Biology, Geology, Law, Anthropology, History, Feminism, Archaeology, Sustainability, Sociology of knowledge, Art, Climate ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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  • 8
    Publication Date: 2023-02-08
    Description: Caribbean reefs have experienced unprecedented changes in the past four decades. Of great concern is the perceived widespread shift from coral to macroalgal dominance and the question of whether it represents a new, stable equilibrium for coral-reef communities. The primary causes of the shift—grazing pressure (top-down), nutrient loading (bottom-up) or direct coral mortality (side-in)—still remain somewhat controversial in the coral-reef literature. We have attempted to tease out the relative importance of each of these causes. Four insights emerge from our analysis of an early regional dataset of information on the benthic composition of Caribbean reefs spanning the years 1977–2001. First, although three-quarters of reef sites have experienced coral declines concomitant with macroalgal increases, fewer than 10% of the more than 200 sites studied were dominated by macroalgae in 2001, by even the most conservative definition of dominance. Using relative dominance as the threshold, a total of 49 coral-to-macroalgae shifts were detected. This total represents ~ 35% of all sites that were dominated by coral at the start of their monitoring periods. Four shifts (8.2%) occurred because of coral loss with no change in macroalgal cover, 15 (30.6%) occurred because of macroalgal gain without coral loss, and 30 (61.2%) occurred owing to concomitant coral decline and macroalgal increase. Second, the timing of shifts at the regional scale is most consistent with the side-in model of reef degradation, which invokes coral mortality as a precursor to macroalgal takeover, because more shifts occurred after regional coral-mortality events than expected by chance. Third, instantaneous observations taken at the start and end of the time-series for individual sites showed these reefs existed along a continuum of coral and macroalgal cover. The continuous, broadly negative relationship between coral and macroalgal cover suggests that in some cases coral-to-macroalgae phase shifts may be reversed by removing sources of perturbation or restoring critical components such as the herbivorous sea urchin Diadema antillarum to the system. The five instances in which macroalgal dominance was reversed corroborate the conclusion that macroalgal dominance is not a stable, alternative community state as has been commonly assumed. Fourth, the fact that the loss in regional coral cover and concomitant changes to the benthic community are related to punctuated, discrete events with known causes (i.e. coral disease and bleaching), lends credence to the hypothesis that coral reefs of the Caribbean have been under assault from climate-change-related maladies since the 1970s.
    Type: Article , PeerReviewed
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  • 9
    Publication Date: 2023-02-08
    Description: Facilitated by the intensification of global trading, the introduction and dispersal of species to areas in which they are historically non-native is nowadays common. From an evolutionary standpoint, invasions are paradoxical: not only non-native environments could be different from native ones for which introduced individuals would be ill-adapted, but also small founding population size should be associated with reduced adaptive potential. As such, biological invasions are considered valuable real-time evolutionary experiments. Here, we investigated the population structure and adaptive potential of the highly invasive topmouth gudgeon (Pseudorasbora parva) across Europe and East Asia. We RAD-sequenced 301 specimens from sixteen populations and three distinct within-catchment invaded regions as well as two locations in the native range. With 13,785 single nucleotide polymorphisms, we provide conclusive evidence for a genome-wide signature of two distinct invasion events, in Slovakia and Turkey, each originating from a specific area in the native range. A third invaded area, in France, appears to be the result of dispersal within the invasive range. Few loci showed signs of selection, the vast majority of which being identified in the Slovakian region. Functional annotation suggests that faster early stage development, resistance to pollution and immunocompetence contribute to the invasion success of the local habitats. By showing that populations in the invasive range have different evolutionary histories, our study reinforces the idea that populations, rather than species, are the units to consider in invasion biology.
    Type: Article , PeerReviewed
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  • 10
    Publication Date: 2023-02-08
    Description: Seismic-reflection data along the Haida Gwaii margin collected from 1967 to 2013 were used to identify gas hydrate–related bottom-simulating reflectors (BSRs). The BSRs occur along the Queen Charlotte Terrace only, within more strongly folded and tectonically deformed sedimentary ridges. The BSRs are absent within well-bedded and sediment-filled minibasins. The BSR is modeled as the base of the phase boundary of the methane hydrate (structure I) stability zone and is used to estimate geothermal gradients. The P-wave velocity structure required to convert observed depths of the BSR in two-way time to meters below seafloor was constrained from ocean-bottom seismometers. The BSR-derived gradients are lower than data from heat-probe deployments in the region, as well as predicted values from previous modeling of the large-scale tectonic thermal regime. Lower values of the BSR-derived thermal gradients may be due to topographic effects across the ridges where BSRs were observed. The previously identified landward decrease in thermal gradients across the terrace was also identified to a lesser extent from the BSRs, in accordance with the effects of oblique convergence of the Pacific plate with the North American plate. Geothermal gradients decreased from south to north by a factor of two, which is likely an effect of plate cooling due to an increase in age of the underlying plate (ca. 8 Ma off southern Haida Gwaii to ca. 12 Ma at Dixon Entrance) as well as the fact that sediments triple in thickness over the same distance. This may be due to downward flexure of the underlying crust during transpression and/or a high flux of sediments through Dixon Entrance.
    Type: Article , PeerReviewed
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