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  • 2020-2024  (15)
  • 1935-1939  (2)
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  • 1
    Publication Date: 2024-04-01
    Description: In this study we interrogate 630 compounds of the Maybridge Rule of 3 Fragment Library for compounds that interact with, and inhibit TbCK. The Maybridge Rule of 3 Fragment Library is a small collection of quantifiable diverse, pharmacophoric rich, chemical entities that comply with the following criteria; MW ≤ 300, cLogP ≤ 3, H-Bond Acceptors ≤ 3, H-Bond Donors ≤ 3, Rotatable bonds (Flexibility Index) ≤ 3, Polar Surface Area ≤ 60 Å2 and aqueous solubility ≥ 1 mM using LogS and high purity (≥ 95%). Comparisons between two different screening methods, a coupled enzyme activity assay and differential scanning fluorimetry, has allowed identification of compounds that interact and inhibit the T. brucei choline kinase, several of which possess selective trypanocidal activity. Screening of a comparatively small fragment library by two different screening methods has allowed identification of several compounds that interact with and inhibit TbCK, a genetically validated drug target against African sleeping sickness. Some of the inhibitory fragments were also selectively trypanocidal, considering these are relatively simple molecules with no optimization, finding low μΜ inhibitors is very encouraging. Moreover some of the morphological phenotypes of these trypanocidal compounds include cell-cycle arrests similar to those observed for the TbCK conditional knockout grown under permissive conditions.
    Keywords: pharmacology ; toxicology ; pharmacology ; toxicology ; Assay ; Enzyme ; Molar concentration ; Protein ; Thermal shift assay ; Trypanosoma brucei ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 2
    Publication Date: 2024-04-20
    Description: This dataset contains the gridded correlation results from a study that sought to better understand the climatic footprint monitored by antipodal mid-latitude glacier populations. Understanding the links between glaciers and climate is critical for accurately interpreting contemporary cryosphere changes, and interrogating the causes of past glacier behavior. However, work is still needed to refine the extent to which they capture regional to hemisphere-scale atmospheric processes. A Pearson's correlation was performed between yearly summer seasonal data from the ERA5 gridded reconstructions of global temperature and wind changes on each available ERA5 pressure level and yearly glacier snowline/ELA elevations in the Southern Alps of New Zealand and in the European Alps. December-Febuary austral summer data was correlated with the Southern Alps records and June-August Northern Hemisphere summer data was correlated with the European Alps. The ERA5 input dataset was regridded onto a new monthly axis representing the true month lengths. Then the weighted seasonal average (December-February and June-August) was calculated. Individuals glaciers with Equilibrium Line Altitude (ELA; European Alps) and End of Summer Snowlines (EOSS; Southern Alps) were selected with respective records covering at least 80% of the 1979-2017/15 analysis period. The records from each glacier were then standardized and an EOF analysis was performed to obtain each location's First Principle Component for input into the Pearson's Correlation. A nearly identical set of analyses was performed using weather stations temperature data instead of glacier ELA/snowlines. The New Zealand station equivalent is from the National Institute of Water and Atmospheric Research (NIWA) New Zealand seven-station (NZ7S) series. The European Alps equivalent is from the HistAlp regional weather station syntheses. This companion analysis allows the glacier's ability to record the climate to be compared to that of meteorological instruments.
    Keywords: Alps; Binary Object; Binary Object (File Size); correlation; ERA5; European Alps; File content; glacier; New Zealand; Southern Hemisphere Westerly Winds; Westerlies
    Type: Dataset
    Format: text/tab-separated-values, 14 data points
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  • 3
    Publication Date: 2024-01-20
    Description: Automated bioacoustic analysis aids understanding and protection of both marine and terrestrial \nanimals and their habitats across extensive spatiotemporal scales, and typically involves analyzing \nvast collections of acoustic data. With the advent of deep learning models, classifcation of important \nsignals from these datasets has markedly improved. These models power critical data analyses for \nresearch and decision-making in biodiversity monitoring, animal behaviour studies, and natural \nresource management. However, deep learning models are often data-hungry and require a signifcant \namount of labeled training data to perform well. While sufcient training data is available for certain \ntaxonomic groups (e.g., common bird species), many classes (such as rare and endangered species, \nmany non-bird taxa, and call-type) lack enough data to train a robust model from scratch. This study \ninvestigates the utility of feature embeddings extracted from audio classifcation models to identify \nbioacoustic classes other than the ones these models were originally trained on. We evaluate models \non diverse datasets, including diferent bird calls and dialect types, bat calls, marine mammals calls, \nand amphibians calls. The embeddings extracted from the models trained on bird vocalization data \nconsistently allowed higher quality classifcation than the embeddings trained on general audio \ndatasets. The results of this study indicate that high-quality feature embeddings from large-scale \nacoustic bird classifers can be harnessed for few-shot transfer learning, enabling the learning of new \nclasses from a limited quantity of training data. Our fndings reveal the potential for efcient analyses \nof novel bioacoustic tasks, even in scenarios where available training data is limited to a few samples.
    Repository Name: National Museum of Natural History, Netherlands
    Type: info:eu-repo/semantics/article
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 59 (1937), S. 1387-1388 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    Publication Date: 2024-04-08
    Description: In this book social responsive theological research converges to provide practical theological and ecclesiological perspectives on the growing human dilemma of displacement. The book presents the research of practical theologians, a missiologist and a religious practitioner whose work pertains first and foremost to the (South) African context. The different fields of expertise of the contributors within the broader field of practical theology worked towards a unique compilation of themes, each relevant to the issue at stake. The majority of chapters are theoretically orientated, except where authors refer to empirical work conducted during previous research. The main contribution of this collaborative work is to be sought in the practical theological and ecclesiological perspectives it provides. It engages the critical questions of what kind of church we need, and what kind of care we should provide in the face of the growing predicament of human displacement. The theological and theoretical principles uncovered in the different chapters will be of use to theologians from all theological subdisciplines, as well as to religious practitioners and leaders of faith communities that are challenged with the growing realities of strangers on their doorsteps and in their pews.
    Keywords: Pastoral care ; Ecclesiology ; Practical Theology ; Xenophobia ; Displacement crisis ; Co-existence ; Human displacement ; bic Book Industry Communication::H Humanities::HR Religion & beliefs::HRC Christianity ; bic Book Industry Communication::H Humanities::HR Religion & beliefs::HRA Religion: general::HRAM Religious issues & debates ; bic Book Industry Communication::H Humanities::HR Religion & beliefs::HRA Religion: general::HRAM Religious issues & debates::HRAM9 Religious intolerance, persecution & conflict ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRM Christianity ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRA Religion: general::QRAM Religious issues and debates ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRA Religion: general::QRAM Religious issues and debates::QRAM9 Religious intolerance, persecution and conflict
    Language: English
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  • 6
    Publication Date: 2024-02-29
    Description: Post-coronavirus disease 2019 (COVID-19) realities are challenging leaders in all spheres of society in many ways. From the onset of the pandemic, leaders on every level were challenged to provide appropriate guidance in the face of new and adverse realities. From the micro level of local congregations to the macro level of national governments, leaders were required to provide the type of leadership that would not only address immediate obstacles but simultaneously be visionary in the face of uncertainties that became the hallmark of post-COVID-19 society. In this book, the authors reflect on leadership in a post-COVID-19 society from bibliological, practical, theological, missiological and ethical perspectives. Although the authors have the global village in mind, the focus leans towards the African context. The book aims to contribute meaningfully to a much-needed and re-imagined vision of leaders which fits post-COVID-19 societies.
    Keywords: Leadership;Biblical theology;Africa;post-COVID-19;COVID-19;contextualization;government ; bic Book Industry Communication::H Humanities::HR Religion & beliefs::HRC Christianity::HRCV Christian life & practice
    Language: English
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  • 7
    Publication Date: 2024-04-06
    Description: This is the second book in the 'Health, Functioning and Technology' series. The focus of this book is on teaching, learning and assessment in rehabilitation education within the African context. The primary contributors to the book are authors from occupational therapy, physiotherapy and speech-language therapy in South Africa. The authors discuss local contextual drivers for renewing rehabilitation professions curricula that support graduates in becoming competent, socially accountable, and dynamic. The foundational element of the chapters in the book is the African context and evidence-informed educational practice. We include the impact of the COVID-19 pandemic on teaching, learning, student support and the integration of technology to assist in achieving the goals of the curricula. Through the different themes of transformative learning, curriculum renewal, technology for learning and clinical training key topics are covered on responsive curricula, leadership, interprofessional education, clinical competence, critical consciousness, peer teaching and learning, learning technologies, student support and emergency remote teaching and learning.
    Keywords: Curriculum reform;transformative learning;leadership;interprofessional education;clinical competence;peer teaching and learning;learning technologies ; thema EDItEUR::M Medicine and Nursing::MQ Nursing and ancillary services::MQS Physiotherapy
    Language: English
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  • 8
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    Frontiers Media SA
    Publication Date: 2024-03-31
    Description: Sympathetic overactivity is associated with the development of hypertension. Renal denervation (RDN) prevents or delays hypertension in a variety of animal models, which laid the groundwork for the introduction of RDN as a clinical therapy in humans. In 2007, a novel, minimally invasive RDN ablation catheter was first trialled in hypertensive patients, with a 93% success rate of lowering blood pressure for at least three years post-RDN. However, a large scale, sham-controlled clinical trial (Symplicity HTN -3) failed to show reductions in BP greater than sham. The aim of this research topic was to evaluate the efficacy and safety of RDN, to explore the contribution of both afferent and efferent renal nerve activity to hypertension and non-hypertension disorders, and to stimulate future research to better understand the function of the renal nerves and the effects of RDN by highlighting gaps in knowledge.
    Keywords: QP1-981 ; Q1-390 ; atherosclerosis ; heart failure ; renal denervation ; renal sympathetic nerves ; kidney disease ; hypertension ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
    Language: English
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  • 9
    Publication Date: 1937-07-01
    Print ISSN: 0002-7863
    Electronic ISSN: 1520-5126
    Topics: Chemistry and Pharmacology
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  • 10
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