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  • 2020-2024  (15)
  • 1995-1999  (220)
  • 1970-1974  (70)
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  • 1
    Signatur: MOP Per 701/B(NF, 74, 1-12)
    In: Meteorologische Abhandlungen
    Materialart: Monographie ausleihbar
    Seiten: Getr. Zählung
    Serie: Meteorologische Abhandlungen : Serie B, Grundlagenmaterial N. F., 74, 1-12
    Standort: MOP - Bitte bestellen
    Zweigbibliothek: GFZ Bibliothek
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Signatur: AWI G5-99-0095
    In: Quaternary Research, Volume 3, Issue 2
    Materialart: Monographie ausleihbar
    Seiten: Seite 155-205 , Illustrationen , 30 cm
    ISSN: 0033-5894 (Print) , 1096-0287 (Online)
    Serie: Quaternary Research 3,2
    Sprache: Englisch
    Standort: AWI Lesesaal
    Zweigbibliothek: AWI Bibliothek
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Monographie ausleihbar
    Monographie ausleihbar
    London ; New York : Taylor & Francis
    Signatur: PIK B 160-03-0320
    Materialart: Monographie ausleihbar
    Seiten: 256 p.
    Ausgabe: 1. ed.
    ISBN: 0415192153
    Standort: A 18 - Bitte bestellen
    Zweigbibliothek: PIK Bibliothek
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Publikationsdatum: 2024-04-01
    Beschreibung: In this study we interrogate 630 compounds of the Maybridge Rule of 3 Fragment Library for compounds that interact with, and inhibit TbCK. The Maybridge Rule of 3 Fragment Library is a small collection of quantifiable diverse, pharmacophoric rich, chemical entities that comply with the following criteria; MW ≤ 300, cLogP ≤ 3, H-Bond Acceptors ≤ 3, H-Bond Donors ≤ 3, Rotatable bonds (Flexibility Index) ≤ 3, Polar Surface Area ≤ 60 Å2 and aqueous solubility ≥ 1 mM using LogS and high purity (≥ 95%). Comparisons between two different screening methods, a coupled enzyme activity assay and differential scanning fluorimetry, has allowed identification of compounds that interact and inhibit the T. brucei choline kinase, several of which possess selective trypanocidal activity. Screening of a comparatively small fragment library by two different screening methods has allowed identification of several compounds that interact with and inhibit TbCK, a genetically validated drug target against African sleeping sickness. Some of the inhibitory fragments were also selectively trypanocidal, considering these are relatively simple molecules with no optimization, finding low μΜ inhibitors is very encouraging. Moreover some of the morphological phenotypes of these trypanocidal compounds include cell-cycle arrests similar to those observed for the TbCK conditional knockout grown under permissive conditions.
    Schlagwort(e): pharmacology ; toxicology ; pharmacology ; toxicology ; Assay ; Enzyme ; Molar concentration ; Protein ; Thermal shift assay ; Trypanosoma brucei ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
    Format: image/jpeg
    Format: image/jpeg
    Format: image/jpeg
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Publikationsdatum: 2024-04-20
    Beschreibung: This dataset contains the gridded correlation results from a study that sought to better understand the climatic footprint monitored by antipodal mid-latitude glacier populations. Understanding the links between glaciers and climate is critical for accurately interpreting contemporary cryosphere changes, and interrogating the causes of past glacier behavior. However, work is still needed to refine the extent to which they capture regional to hemisphere-scale atmospheric processes. A Pearson's correlation was performed between yearly summer seasonal data from the ERA5 gridded reconstructions of global temperature and wind changes on each available ERA5 pressure level and yearly glacier snowline/ELA elevations in the Southern Alps of New Zealand and in the European Alps. December-Febuary austral summer data was correlated with the Southern Alps records and June-August Northern Hemisphere summer data was correlated with the European Alps. The ERA5 input dataset was regridded onto a new monthly axis representing the true month lengths. Then the weighted seasonal average (December-February and June-August) was calculated. Individuals glaciers with Equilibrium Line Altitude (ELA; European Alps) and End of Summer Snowlines (EOSS; Southern Alps) were selected with respective records covering at least 80% of the 1979-2017/15 analysis period. The records from each glacier were then standardized and an EOF analysis was performed to obtain each location's First Principle Component for input into the Pearson's Correlation. A nearly identical set of analyses was performed using weather stations temperature data instead of glacier ELA/snowlines. The New Zealand station equivalent is from the National Institute of Water and Atmospheric Research (NIWA) New Zealand seven-station (NZ7S) series. The European Alps equivalent is from the HistAlp regional weather station syntheses. This companion analysis allows the glacier's ability to record the climate to be compared to that of meteorological instruments.
    Schlagwort(e): Alps; Binary Object; Binary Object (File Size); correlation; ERA5; European Alps; File content; glacier; New Zealand; Southern Hemisphere Westerly Winds; Westerlies
    Materialart: Dataset
    Format: text/tab-separated-values, 14 data points
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    Publikationsdatum: 2024-01-20
    Beschreibung: Automated bioacoustic analysis aids understanding and protection of both marine and terrestrial \nanimals and their habitats across extensive spatiotemporal scales, and typically involves analyzing \nvast collections of acoustic data. With the advent of deep learning models, classifcation of important \nsignals from these datasets has markedly improved. These models power critical data analyses for \nresearch and decision-making in biodiversity monitoring, animal behaviour studies, and natural \nresource management. However, deep learning models are often data-hungry and require a signifcant \namount of labeled training data to perform well. While sufcient training data is available for certain \ntaxonomic groups (e.g., common bird species), many classes (such as rare and endangered species, \nmany non-bird taxa, and call-type) lack enough data to train a robust model from scratch. This study \ninvestigates the utility of feature embeddings extracted from audio classifcation models to identify \nbioacoustic classes other than the ones these models were originally trained on. We evaluate models \non diverse datasets, including diferent bird calls and dialect types, bat calls, marine mammals calls, \nand amphibians calls. The embeddings extracted from the models trained on bird vocalization data \nconsistently allowed higher quality classifcation than the embeddings trained on general audio \ndatasets. The results of this study indicate that high-quality feature embeddings from large-scale \nacoustic bird classifers can be harnessed for few-shot transfer learning, enabling the learning of new \nclasses from a limited quantity of training data. Our fndings reveal the potential for efcient analyses \nof novel bioacoustic tasks, even in scenarios where available training data is limited to a few samples.
    Repository-Name: National Museum of Natural History, Netherlands
    Materialart: info:eu-repo/semantics/article
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 3 (1996), S. 3861-3863 
    ISSN: 1089-7674
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: Low-frequency magnetohydrodynamic equations including the effects of finite ion Larmor radius are derived. These equations contain all the physical terms necessary to describe kinetic Alfvén waves. Among other applications, these waves are used to interpret ultra-low-frequency wave phenomena in the Earth's magnetosphere. The finite ion Larmor radius effects are usually disregarded; however, under magnetospheric conditions, the ion temperature cannot be considered negligible since Ti≥Te. The finite ion gyroradius is accounted for by the ion stress tensor calculated in this Brief Communication. The nonlinear one-fluid system of equations is shown to adequately describe linear kinetic Alfvén waves in a low-β(β(very-much-less-than)1) homogeneous plasma. It is demonstrated that energy of the plasma system is conserved. © 1996 American Institute of Physics.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Review of income and wealth 19 (1973), S. 0 
    ISSN: 1475-4991
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Wirtschaftswissenschaften
    Notizen: This paper entails an investigation of the effects of data revisions on forecasting accuracy, through use of preliminary and revised national accounting data compiled by the United Nations. A small model was estimated for each of fourteen countries and ex post“forecasts” generated for each country and each year of the period 1957–1964, using first preliminary and then revised data.A prior analysis of the data revisions indicated a strong and widespread tendency for the preliminary estimates to understate both levels and year-to-year changes. This is consistent with the findings of other studies.Two sets of forecasts obtained from the reduced form of the model were considered in relation to “actual” levels and changes, obtained from the revised data, and also in relation to each other. A strong downward bias was observed in the forecasts of levels based on preliminary data, and a weaker one in the forecasts of changes. The forecast discrepancies for different variables were found to be significantly correlated.The results suggest that a tendency toward understatement in preliminary data may account in part for the general tendency toward understatement in forecasts noted in other studies.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
    Digitale Medien
    Digitale Medien
    s.l. : American Chemical Society
    Inorganic chemistry 11 (1972), S. 1135-1137 
    ISSN: 1520-510X
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
    ISSN: 1520-6904
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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