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  • 2020-2024  (41)
  • 2015-2019  (925)
  • 1975-1979  (184)
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  • 1
    Online Resource
    Online Resource
    Targets of Cancer Diagnosis and Treatment : Ion Transport in Tumor Biology (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Clinical biochemistry. ; Pharmacology. ; Human physiology. ; Internal medicine. ; Physiology. ; Biomedical Research. ; Medical Biochemistry. ; Pharmacology. ; Human Physiology. ; Internal Medicine. ; Physiology.
    Description / Table of Contents: Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges -- Novel Therapeutic Approaches of Ion Channels and Transporters in Cancer -- Ion Channels in Cancer: Orchestrators of Electrical Signaling and Cellular Crosstalk -- Potassium and Chloride Ion Channels in Cancer: A Novel Paradigm for Cancer Therapeutics -- Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research -- Solute Carrier Transportome in Chemotherapy-Induced Adverse Drug Reactions -- Ion Transport and Radioresistance -- Ion Transporting Proteins and Cancer: Progress and Perspectives.
    Abstract: Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges Alina L. Capatina, Dimitris Lagos, and William J. Brackenbury Novel Therapeutic Approaches of Ion Channels and Transporters in Cancer Ana Ramírez, Janice García-Quiroz, Luis Aguilar-Eslava, Yesennia Sánchez-Pérez, and Javier Camacho Ion Channels in Cancer: Orchestrators of Electrical Signaling and Cellular Crosstalk Jerry J. Fan and Xi Huang Potassium and Chloride Ion Channels in Cancer: A Novel Paradigm for Cancer Therapeutics Umberto Banderali, Luigi Leanza, Najmeh Eskandari, and Saverio Gentile Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research Marie Potier-Cartereau, William Raoul, Gunther Weber, Karine Mahéo, Raphael Rapetti-Mauss, Maxime Gueguinou, Paul Buscaglia, Caroline Goupille, Nelig Le Goux, Souleymane Abdoul-Azize, Thierry Lecomte, Gaëlle Fromont, Aurélie Chantome, Olivier Mignen, Olivier Soriani, and Christophe Vandier Solute Carrier Transportome in Chemotherapy-Induced Adverse Drug Reactions Jason T. Anderson, Kevin M. Huang, Maryam B. Lustberg, Alex Sparreboom, and Shuiying Hu Ion Transport and Radioresistance Bastian Roth and Stephan M. Huber Ion Transporting Proteins and Cancer: Progress and Perspectives Mustafa B. A. Djamgoz.
    Type of Medium: Online Resource
    Pages: X, 277 p. 30 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031039942
    Series Statement: Reviews of Physiology, Biochemistry and Pharmacology, 183
    URL: https://doi.org/10.1007/978-3-031-03994-2
    DOI: 10.1007/978-3-031-03994-2
    DDC: 610.72
    Language: English
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  • 2
    Online Resource
    Online Resource
    Transportome Malfunction in the Cancer Spectrum : Ion Transport in Tumor Biology (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Clinical biochemistry. ; Pharmacology. ; Human physiology. ; Internal medicine. ; Physiology. ; Biomedical Research. ; Medical Biochemistry. ; Pharmacology. ; Human Physiology. ; Internal Medicine. ; Physiology.
    Description / Table of Contents: Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression -- Ion Channel Profiling in Prostate Cancer: Toward Cell Population-Specific Screening -- Ion channels in Lung Cancer -- Contribution and Expression of Organic Cation Transporters and Aquaporin Water Channels in Renal Cancer -- Transportome Malfunctions and the Hallmarks of Pancreatic Cancer -- How Dysregulated Ion Channels and Transporters Take a Hand in Esophageal, Liver, and Colorectal Cancer -- Ion Channels in Glioma Malignancy -- Membrane Transporters and Channels in Melanoma -- Ion Channel Dysregulation in Head and Neck Cancers: Perspectives for Clinical Application.
    Abstract: Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression Halima Ouadid-Ahidouch, Hamid Morjani, Julie Schnipper, Alban Girault, and Ahmed Ahidouch Ion Channel Profiling in Prostate Cancer: Toward Cell Population-Specific Screening Valerio Farfariello, Natalia Prevarskaya, and Dimitra Gkika Ion Channels in Lung Cancer Etmar Bulk, Luca Matteo Todesca, and Albrecht Schwab Contribution and Expression of Organic Cation Transporters and Aquaporin Water Channels in Renal Cancer Giuliano Ciarimboli, Gerit Theil, Joanna Bialek, and Bayram Edemir Transportome Malfunctions and the Hallmarks of Pancreatic Cancer Qi Ling and Holger Kalthoff How Dysregulated Ion Channels and Transporters Take a Hand in Esophageal, Liver, and Colorectal Cancer Christian Stock Ion Channels in Glioma Malignancy Luigi Catacuzzeno, Luigi Sforna, Vincenzo Esposito, Cristina Limatola, and Fabio Franciolini Membrane Transporters and Channels in Melanoma Ines Böhme, Roland Schönherr, Jürgen Eberle, and Anja Katrin Bosserhoff Ion Channel Dysregulation in Head and Neck Cancers: Perspectives for Clinical Application Nagore Del-Río-Ibisate, Rocío Granda-Díaz, Juan P. Rodrigo, Sofía T. Menéndez, and Juana M. García-Pedrero.
    Type of Medium: Online Resource
    Pages: IX, 427 p. 50 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030909208
    Series Statement: Reviews of Physiology, Biochemistry and Pharmacology, 181
    URL: https://doi.org/10.1007/978-3-030-90920-8
    DOI: 10.1007/978-3-030-90920-8
    DDC: 610.72
    Language: English
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  • 3
    Online Resource
    Online Resource
    From Malignant Transformation to Metastasis : Ion Transport in Tumor Biology (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Clinical biochemistry. ; Pharmacology. ; Human physiology. ; Physiology. ; Biomedical Research. ; Medical Biochemistry. ; Pharmacology. ; Human Physiology. ; Physiology.
    Description / Table of Contents: How Reciprocal Interactions Between the Tumor Microenvironment and Ion Transport Proteins Drive Cancer Progression -- Ion Channels, Transporters, and Sensors Interact with the Acidic Tumor Microenvironment to Modify Cancer Progression -- Role of pH Regulatory Proteins and Dysregulation of pH in Prostate Cancer -- Calcium-Permeable Channels in Tumor Vascularization: Peculiar Sensors of Microenvironmental Chemical and Physical Cues -- Circulating Tumor Cells: Does Ion Transport Contribute to Intravascular Survival, Adhesion, Extravasation, and Metastatic Organotropism?.
    Abstract: How Reciprocal Interactions Between the Tumor Microenvironment and Ion Transport Proteins Drive Cancer Progression Line O. Elingaard-Larsen, Michala G. Rolver, Ester E. Sørensen, and Stine F. Pedersen Ion Channels, Transporters, and Sensors Interact with the Acidic Tumor Microenvironment to Modify Cancer Progression Ebbe Boedtkjer Role of pH Regulatory Proteins and Dysregulation of pH in Prostate Cancer Larry Fliegel Calcium-Permeable Channels in Tumor Vascularization: Peculiar Sensors of Microenvironmental Chemical and Physical Cues Giorgia Scarpellino, Luca Munaron, Anna Rita Cantelmo, and Alessandra Fiorio Pla Circulating Tumor Cells: Does Ion Transport Contribute to Intravascular Survival, Adhesion, Extravasation, and Metastatic Organotropism? Christian Stock.
    Type of Medium: Online Resource
    Pages: XV, 175 p. 40 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030998004
    Series Statement: Reviews of Physiology, Biochemistry and Pharmacology, 182
    URL: https://doi.org/10.1007/978-3-030-99800-4
    DOI: 10.1007/978-3-030-99800-4
    DDC: 610.72
    Language: English
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  • 4
    Monograph available for loan
    Monograph available for loan
    Hydrodynamik : (Spezielle Kapitel); Bd. 2a. (1978)
    Thun [u.a.] : Deutsch
    Associated volumes
    Details Availability
    Call number: 16/O 6343/2a ; 13657/IIa
    In: Theoretische Physik
    Type of Medium: Monograph available for loan
    Pages: IX, 456 S.
    ISBN: 3871444634
    Location: Reading room
    Location: Upper compact magazine
    Branch Library: GFZ Library
    Branch Library: GFZ Library
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  • 5
    Monograph available for loan
    Monograph available for loan
    The good farmer : culture and identity in food and agriculture (2021)
    London : Routledge
    Details Availability
    Call number: PIK W 100-22-94745
    Description / Table of Contents: The 'good farmer': cultural dimensions of farming and social change -- The origins of the 'good farmer' -- How symbols of 'good farming' develop: the historical development of 'tidy farming' -- Theorising the 'good farmer': from common sense category to analytical construct -- Morality and the 'good farmer' -- The gendered 'good farmer' -- The 'good farmer' in communities of practice -- Future challenges for the 'good farmer'.
    Description / Table of Contents: "Developed by the leading authors in the field, this book provides a cohesive and definitive theorisation of the concept of the 'good farmer', addressing the blind spots that have sprung up in agri-food literature as well as providing a springboard for future research. The concept of the good farmer has emerged in recent years as part of a move away from attitude and economics based understandings of farm decision-making towards a deeper understanding of culture and symbolism in agriculture. The Good Farmer shows why agricultural production is socially and culturally, as well as economically, important. It explores the history of the concept and its position in contemporary theory, as well as its use and meaning in a variety of different contexts, including landscape, environment, gender, society, and as a tool for resistance. By exploring the idea of the good farmer, it reveals the often-unforeseen assumptions implicit in food and agricultural policy that draw on culture, identity, and presumed notions of what is good. Finally, the book looks at the potential of the good farmer concept for addressing future, emerging issues in agriculture. This book will be of interest to students and scholars of food and agriculture and rural development, as well and professionals and policymakers involved in the food and agricultural industry"
    Type of Medium: Monograph available for loan
    Pages: xi, 184 Seiten , Illustrationen
    ISBN: 978-1-138-72796-0
    Series Statement: Earthscan food and agriculture series
    Language: English
    Branch Library: PIK Library
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  • 6
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    Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer’s disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid (2017)
    Public Library of Science
    Details
    Publication Date: 2017-12-18
    Electronic ISSN: 1932-6203
    Topics: Medicine , Natural Sciences in General
    Published by Public Library of Science
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  • 7
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    The stromatoporoid Habrostroma in the upper Silurian (uppermost Pridoli)–Lower Devonian (Lochkovian) of North America, and the paleobiogeographic significance of H. centrotum (Girty, 1895) (2019)
    Paleontological Society
    Details
    Publication Date: 2019-09-18
    Description: Three species of Habrostroma dominate stromatoporoid faunas in the Lower Devonian (Lochkovian) of five areas in North America: New York, Virginia, Maine, Bathurst Island, and Ellesmere Island. In addition, they occur in what could be the upper Silurian (uppermost Pridoli) of Virginia, and possibly New York. Measurements of nine morphologies from 127 specimens of Habrostroma were subjected to an average linkage cluster analysis. Using average linkage between groups, three distinct clusters were revealed. Group assignments made from the cluster analysis were saved, and entered into a canonical discriminant analysis with the nine morphological variables. An overall Wilks’ lambda was calculated, and is statistically significant at alpha 〈0.001. The hit rate for classifying group 1 is 98%, that for group 2 is 100%, and that for group 3 is 97.9%; the total hit rate is 100%. The morphological variables contributing most to group membership are: (1) percent cystlike microlaminae, (2) microlaminae per mm, (3) gallery height, (4) laminae per mm, and (5) laminar thickness. The statistics confirm that there are three species: H. centrotum, H. microporum, and H. consimile.Habrostroma centrotum occurs in all five areas. This is unusual because Virginia, New York, and Maine are part of the Eastern Americas Realm, and the arctic islands are part of the Old World Realm. Separation of the realms is based on a high percentage of unique genera in each. A breach in the inter-realm barrier is proposed to have existed across the Canadian Shield during the Lochkovian. The nature of the breach is determined to be a shallow-water filter, allowing the passage of a limited number of taxa.
    Print ISSN: 0022-3360
    Electronic ISSN: 1937-2337
    Topics: Geosciences
    Published by Paleontological Society
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  • 8
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    N-Acyl Homoserine Lactone Derived Tetramic Acids Impair Photosynthesis in Phaeodactylum tricornutum (2019)
    American Chemical Society
    Details
    Publication Date: 2019-01-29
    Print ISSN: 1554-8929
    Electronic ISSN: 1554-8937
    Topics: Biology , Chemistry and Pharmacology
    Published by American Chemical Society
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  • 9
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    AGSE: A Novel Grape Seed Extract Enriched for PP2A Activating Flavonoids That Combats Oxidative Stress and Promotes Skin Health (2021)
    Molecular Diversity Preservation International
    Details
    Publication Date: 2021-10-20
    Description: Environmental stimuli attack the skin daily resulting in the generation of reactive oxygen species (ROS) and inflammation. One pathway that regulates oxidative stress in skin involves Protein Phosphatase 2A (PP2A), a phosphatase which has been previously linked to Alzheimer’s Disease and aging. Oxidative stress decreases PP2A methylation in normal human dermal fibroblasts (NHDFs). Thus, we hypothesize agents that increase PP2A methylation and activity will promote skin health and combat aging. To discover novel inhibitors of PP2A demethylation activity, we screened a library of 32 natural botanical extracts. We discovered Grape Seed Extract (GSE), which has previously been reported to have several benefits for skin, to be the most potent PP2A demethylating extract. Via several fractionation and extraction steps we developed a novel grape seed extract called Activated Grape Seed Extract (AGSE), which is enriched for PP2A activating flavonoids that increase potency in preventing PP2A demethylation when compared to commercial GSE. We then determined that 1% AGSE and 1% commercial GSE exhibit distinct gene expression profiles when topically applied to a 3D human skin model. To begin to characterize AGSE’s activity, we investigated its antioxidant potential and demonstrate it reduces ROS levels in NHDFs and cell-free assays equal to or better than Vitamin C and E. Moreover, AGSE shows anti-inflammatory properties, dose-dependently inhibiting UVA, UVB and chemical-induced inflammation. These results demonstrate AGSE is a novel, multi-functional extract that modulates methylation levels of PP2A and supports the hypothesis of PP2A as a master regulator for oxidative stress signaling and aging in skin.
    Electronic ISSN: 1420-3049
    Topics: Chemistry and Pharmacology
    Published by Molecular Diversity Preservation International
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  • 10
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    Effect of atorvastatin on haemocytes of the blue mussels, Mytilus edulis (2019)
    PANGAEA
    Details
    Publication Date: 2023-01-30
    Description: Increasing concentration of biologically active pharmaceutical compounds can affect marine organisms. The bioavailability and environmental stability of these compounds make them potential threat to these organisms, specially the sessile organisms. We have examined the effects of atorvastatin, a globally prescribed drug, on the blue mussels – Mytilus edulis. In this data set, we presents the effect of atorvastatin (ATO) on the haemocyte counts of Mytilus edulis.
    Keywords: Atorvastatin; haemocyte; Hemocytes; Mytilus edulis; Sample ID; Species; Time in weeks; Treatment
    Type: Dataset
    Format: text/tab-separated-values, 65 data points
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