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  • 2020-2024  (15)
  • 2015-2019  (402)
  • 2000-2004  (163)
  • 1935-1939  (2)
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  • 1
    Monograph available for loan
    Monograph available for loan
    Schweden
    Call number: AWI G5-02-0107
    Type of Medium: Monograph available for loan
    Pages: S. 139-432
    Series Statement: Geografiska Annaler Series A: Physical Geography 82A, 2000
    Branch Library: AWI Library
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  • 2
    Publication Date: 2024-04-01
    Description: In this study we interrogate 630 compounds of the Maybridge Rule of 3 Fragment Library for compounds that interact with, and inhibit TbCK. The Maybridge Rule of 3 Fragment Library is a small collection of quantifiable diverse, pharmacophoric rich, chemical entities that comply with the following criteria; MW ≤ 300, cLogP ≤ 3, H-Bond Acceptors ≤ 3, H-Bond Donors ≤ 3, Rotatable bonds (Flexibility Index) ≤ 3, Polar Surface Area ≤ 60 Å2 and aqueous solubility ≥ 1 mM using LogS and high purity (≥ 95%). Comparisons between two different screening methods, a coupled enzyme activity assay and differential scanning fluorimetry, has allowed identification of compounds that interact and inhibit the T. brucei choline kinase, several of which possess selective trypanocidal activity. Screening of a comparatively small fragment library by two different screening methods has allowed identification of several compounds that interact with and inhibit TbCK, a genetically validated drug target against African sleeping sickness. Some of the inhibitory fragments were also selectively trypanocidal, considering these are relatively simple molecules with no optimization, finding low μΜ inhibitors is very encouraging. Moreover some of the morphological phenotypes of these trypanocidal compounds include cell-cycle arrests similar to those observed for the TbCK conditional knockout grown under permissive conditions.
    Keywords: pharmacology ; toxicology ; pharmacology ; toxicology ; Assay ; Enzyme ; Molar concentration ; Protein ; Thermal shift assay ; Trypanosoma brucei ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
    Format: image/jpeg
    Format: image/jpeg
    Format: image/jpeg
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  • 3
    Publication Date: 2015-03-22
    Description: Knowledge of the plasma fluxes at geosynchronous orbit is important to both scientific and operational investigations. We present a new empirical model of the ion flux and the electron flux at geosynchronous orbit (GEO) in the energy range ~1 eV to ~40 keV. The model is based on a total of 82 satellite-years of observations from the Magnetospheric Plasma Analyzer instruments on Los Alamos National Laboratory satellites at GEO. These data are assigned to a fixed grid of 24 local-times and 40 energies, at all possible values of Kp. Bi-linear interpolation is used between grid points to provide the ion flux and the electron flux values at any energy and local-time, and for given values of geomagnetic activity (proxied by the 3-hour Kp index), and also for given values of solar activity (proxied by the daily F10.7 index). Initial comparison of the electron flux from the model with data from a Compact Environmental Anomaly Sensor II (CEASE-II), also located at geosynchronous orbit, indicate a good match during both quiet and disturbed periods. The model is available for distribution as a FORTRAN code that can be modified to suit user-requirements.
    Print ISSN: 1539-4964
    Electronic ISSN: 1542-7390
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 4
    Publication Date: 2018-02-22
    Description: This paper investigates the potential for 83.4 nm imaging of the plasmaspheric dense oxygen torus, using simple models for core plasma density and composition to constrain a simulated image code. We derive the requirements for plasmaspheric O + imaging, and the expected performance of an imager based on a slightly modified version of the IMAGE EUV camera. We find that such an imager can achieve a sensitivity of 0.69(sRpixel) −1 , sufficient to capture the dense torus 83.4 nm signal with 25-min integration time. The background rejection ratios for this design are 1.5 × 10 −4 at 58.4 nm and 7.4 × 10 −8 for Lyman- α . We discuss the effects of ion temperature and motion, and O ++ glow. We compute simulated O + images of the formation and global distribution of the dense torus. We also examine the possibility of direct observation of oxygen outflow from the ionosphere.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 5
    Publication Date: 2018-03-26
    Description: This paper investigates the potential for 83.4 nm imaging of the plasmaspheric dense oxygen torus, using simple models for core plasma density and composition to constrain a simulated image code. We derive the requirements for plasmaspheric O + imaging, and the expected performance of an imager based on a slightly modified version of the IMAGE extreme ultraviolet camera. We find that such an imager can achieve a sensitivity of 0.69(s R pixel) −1 , sufficient to capture the dense torus 83.4 nm signal with 25 min integration time. The background rejection ratios for this design are 1.5 × 10 −4 at 58.4 nm and 7.4 × 10 −8 for Lyman-α. We discuss the effects of ion temperature and motion, and O ++ glow. We compute simulated O + images of the formation and global distribution of the dense torus. We also examine the possibility of direct observation of oxygen outflow from the ionosphere. ©2018. American Geophysical Union. All Rights Reserved.
    Print ISSN: 2169-9380
    Electronic ISSN: 2169-9402
    Topics: Geosciences , Physics
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  • 6
    Publication Date: 2015-04-01
    Print ISSN: 1542-7390
    Electronic ISSN: 1542-7390
    Topics: Geosciences , Physics
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  • 7
    Publication Date: 2019-09-01
    Print ISSN: 1364-6826
    Electronic ISSN: 1879-1824
    Topics: Geosciences , Physics
    Published by Elsevier
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  • 8
    Publication Date: 2024-04-20
    Description: This dataset contains the gridded correlation results from a study that sought to better understand the climatic footprint monitored by antipodal mid-latitude glacier populations. Understanding the links between glaciers and climate is critical for accurately interpreting contemporary cryosphere changes, and interrogating the causes of past glacier behavior. However, work is still needed to refine the extent to which they capture regional to hemisphere-scale atmospheric processes. A Pearson's correlation was performed between yearly summer seasonal data from the ERA5 gridded reconstructions of global temperature and wind changes on each available ERA5 pressure level and yearly glacier snowline/ELA elevations in the Southern Alps of New Zealand and in the European Alps. December-Febuary austral summer data was correlated with the Southern Alps records and June-August Northern Hemisphere summer data was correlated with the European Alps. The ERA5 input dataset was regridded onto a new monthly axis representing the true month lengths. Then the weighted seasonal average (December-February and June-August) was calculated. Individuals glaciers with Equilibrium Line Altitude (ELA; European Alps) and End of Summer Snowlines (EOSS; Southern Alps) were selected with respective records covering at least 80% of the 1979-2017/15 analysis period. The records from each glacier were then standardized and an EOF analysis was performed to obtain each location's First Principle Component for input into the Pearson's Correlation. A nearly identical set of analyses was performed using weather stations temperature data instead of glacier ELA/snowlines. The New Zealand station equivalent is from the National Institute of Water and Atmospheric Research (NIWA) New Zealand seven-station (NZ7S) series. The European Alps equivalent is from the HistAlp regional weather station syntheses. This companion analysis allows the glacier's ability to record the climate to be compared to that of meteorological instruments.
    Keywords: Alps; Binary Object; Binary Object (File Size); correlation; ERA5; European Alps; File content; glacier; New Zealand; Southern Hemisphere Westerly Winds; Westerlies
    Type: Dataset
    Format: text/tab-separated-values, 14 data points
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  • 9
    Publication Date: 2020-11-25
    Description: This chapter provides an overview of last two decades, European experiences in educational seismology and describes the different contexts in which they have been developed. The basic idea of these educational projects is that Seismology may represent an efficient communication vehicle for teaching a wide range of basic Earth sci-ence topics through laboratory practices and educational activities. Moreover it is also an effective tool to raise in the young citizens the awareness on the earthquake risk and possible mitigation actions. In this frame several seismic stations with different technologies were installed in schools across Europe. The scientific support of re-searchers and the need to establish strong links between teachers and researchers attribute to the school an active role in the knowledge process using the scientific laboratory practice by adopting the “learning by doing” modern approach of science communication (R. Schank and C. Cleary, 1995, Engines for Education, Ed. Routledge, 248 pp). Some educational activities correlated with seismological projects are presented, following different strategies depending on the country, but all aimed at building a new way to communicate science in the schools. The new vogue is the opening toward social networks and blogs. This generalizes the concept of an educational Geoscience website making it an e-platform for science communication and multimedia data sharing, where researchers, teachers, students and education op-erators can interact and constantly be kept informed of ongoing activities and relevant events. All of these 'seismology at school' initiatives rely on the concept of school networking and will merge in the European project NERA (Network of European Research Infrastructures for Earthquake Risk Assessment and Mitigation, http://www.nera-eu.org/) where a spe-cific workpackage is dedicated to networking school seismology programs.
    Description: Published
    Description: 145-170
    Description: 3T. Pericolosità sismica e contributo alla definizione del rischio
    Description: restricted
    Keywords: educational seismology ; educational projects ; learning by doing ; science communication ; school seismology ; 05. General::05.03. Educational, History of Science, Public Issues::05.03.99. General or miscellaneous
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: book chapter
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  • 10
    Publication Date: 2020-03-05
    Description: Ozonesonde data from four sites are analyzed in relation to 191 solar protons events (SPEs) from 1989-2016. Analysis shows ozone depletion (~10-35 km altitude) commencing following the SPEs. Seasonally-corrected ozone data demonstrate that depletions occur only in winter/early-spring above sites where the northern hemisphere polar vortex (PV) can be present. A rapid reduction in stratospheric ozone is observed with the maximum decrease occurring ~10-20 days after SPEs. Ozone levels remain depleted in excess of 30 days. No depletion is observed above sites completely outside the PV. No depletion is observed in relation to 191 random epochs at any site at any time of year. Results point to the role of indirect ozone destruction, most likely via the rapid descent of long-lived NOx species in the PV during the polar winter.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
    Format: application/pdf
    Format: application/pdf
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