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  • 1
    Monograph available for loan
    Monograph available for loan
    Einfache Modelle kontinuierlicher Prozesse (1982)
    Berlin : Verl. Technik
    Associated volumes
    Details Availability
    Call number: G 8187
    In: Reihe Automatisierungstechnik
    Type of Medium: Monograph available for loan
    Pages: 76 S. : graph. Darst.
    Edition: 1. Aufl.
    Series Statement: Reihe Automatisierungstechnik 197
    Location: Upper compact magazine
    Branch Library: GFZ Library
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  • 2
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    Geologie der Intrusiva und Rahmengesteine des Südwest-Adamello (Nord-Italien) (1984)
    Zürich
    Associated volumes
    Details Availability
    Call number: 94.0138
    In: Dissertation / Eidgenössische Technische Hochschule Zürich
    Pages: 253 S.
    Series Statement: Dissertation / Eidgenössische Technische Hochschule Zürich 7612
    Classification:
    Regional Geology
    Language: German
    Branch Library: GFZ Library
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  • 3
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    The Eco‐Exposome Concept: Supporting an Integrated Assessment of Mixtures of Environmental Chemicals (2021)
    Details
    Publication Date: 2022-04-04
    Description: Organisms are exposed to ever‐changing complex mixtures of chemicals over the course of their lifetime. The need to more comprehensively describe this exposure and relate it to adverse health effects has led to formulation of the exposome concept in human toxicology. Whether this concept has utility in the context of environmental hazard and risk assessment has not been discussed in detail. In this Critical Perspective, we propose—by analogy to the human exposome—to define the eco‐exposome as the totality of the internal exposure (anthropogenic and natural chemicals, their biotransformation products or adducts, and endogenous signaling molecules that may be sensitive to an anthropogenic chemical exposure) over the lifetime of an ecologically relevant organism. We describe how targeted and nontargeted chemical analyses and bioassays can be employed to characterize this exposure and discuss how the adverse outcome pathway concept could be used to link this exposure to adverse effects. Available methods, their limitations, and/or requirement for improvements for practical application of the eco‐exposome concept are discussed. Even though analysis of the eco‐exposome can be resource‐intensive and challenging, new approaches and technologies make this assessment increasingly feasible. Furthermore, an improved understanding of mechanistic relationships between external chemical exposure(s), internal chemical exposure(s), and biological effects could result in the development of proxies, that is, relatively simple chemical and biological measurements that could be used to complement internal exposure assessment or infer the internal exposure when it is difficult to measure. Environ Toxicol Chem 2022;41:30–45. © 2021 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
    Description: Illustration of the eco‐exposome assessment and how chemical analysis and bioassays could be used to estimate internal exposure. MIE = molecular initiation event; KE = key event; AO = adverse outcome.
    Description: DAAD German academic exchange service
    Keywords: ddc:577.14
    Language: English
    Type: doc-type:article
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    CITATION GEO-LEO
  • 4
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    Sources and Fate of the Antiandrogenic Fluorescent Dye 4‐Methyl‐7‐Diethylaminocoumarin in Small River Systems (2021)
    Details
    Publication Date: 2022-04-05
    Description: Recently, the potent antiandrogen 4‐methyl‐7‐diethylaminocoumarin (C47) and its potential transformation products 4‐methyl‐7‐ethylaminocoumarin (C47T1) and 4‐methyl‐7‐aminocoumarin (C47T2) were identified as novel environmental contaminants. We assessed for the first time the sources, distribution, and fate of these compounds in aquatic systems using the Holtemme River (Saxony‐Anhalt, Germany), which is a hotspot for these contaminants. To this end, wastewater‐treatment plant (WWTP) influent and effluent samples, surface water samples over 3 years, and the longitudinal profiles in water, sediment, and gammarids were analyzed. From the longitudinal profile of the river stretch, the WWTP of Silstedt was identified as the sole point source for these compounds in the River Holtemme, and exposure concentrations in the low micrograms per liter range could be recorded continuously over 3 years. Analysis of WWTP influent and effluent showed a transformation of approximately half of the C47 into C47T1 and C47T2 but no complete removal. A further attenuation of the three coumarins after discharge into the river could be largely attributed to dilution, while transformation was only approximately 20%, thus suggesting a significant persistence in aquatic systems. Experimentally derived partitioning coefficients between water and sediment organic carbon exceeded those predicted using the OPERA quantitative structure–activity relationship tools and polyparameter linear free‐energy relationships by up to 93‐fold, suggesting cation binding as a significant factor for their sorption behavior. Near‐equilibrium conditions between water and sediment were not observed close to the emitting WWTP but farther downstream in the river. Experimental and predicted bioaccumulation factors for gammarids were closely matching, and the concentrations in field‐sampled gammarids were close to steady state with exposure concentrations in the water phase of the river. Environ Toxicol Chem 2021;40:3078–3091. © 2021 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
    Description: Helmholtz‐Gemeinschaft http://dx.doi.org/10.13039/501100001656
    Description: Bundesministerium für Bildung und Forschung http://dx.doi.org/10.13039/501100002347
    Keywords: ddc:577.614
    Language: English
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  • 5
    Electronic Resource
    Electronic Resource
    Multiconformational synthetic polypeptides (1981)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 103 (1981), S. 6319-6323 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00411a009
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    β-structures of polypeptides with L- and D-residues (1980)
    Springer
    Journal of molecular evolution 15 (1980), S. 231-238 
    Details
    ISSN: 1432-1432
    Keywords: β-structure ; Poly-DL-peptides ; Kinetics of hydrolysis ; Enantiomer enrichment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary It was previously shown that nuclei ofβ-sheets surrounded by unordered segments are formed in polypeptide chains built up with alternating hydrophobic and hydrophilic residues and containing both L- and D-enantiomers. It was also established that segments of residues having the same configuration tend to segregate in these nuclei when the starting composition of stereomonomers departs from the racemic mixture. Soft acidic hydrolysis of these polymers has been studied. Kinetic measurements show two pseudo first order rate constants, in agreement with the existence of two conformational species. The unordered part of the chains is hydrolyzed more rapidly, allowing the isolation of aβ-fraction enriched in one enantiomer. Thus, a plausible process of enrichment in enantiomer during prebiotic evolution has been described, which however does not explain the preference of one enantiomer over the other one.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01732950
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  • 7
    Electronic Resource
    Electronic Resource
    Advertising and Labour Supply: Workweek and Workyear in U. S. Manufacturing Industries, 1919–76 (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Kyklos 36 (1983), S. 0 
    Details
    ISSN: 1467-6435
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-6435.1983.tb02025.x
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  • 8
    Electronic Resource
    Electronic Resource
    Some Investigations on the Ephemerides of the Babylonian Moon Texts, System A (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Centaurus 24 (1980), S. 0 
    Details
    ISSN: 1600-0498
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0498.1980.tb00365.x
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  • 9
    Electronic Resource
    Electronic Resource
    The nuclear surface as a collective variable (1984)
    Springer
    The European physical journal 319 (1984), S. 205-213 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract In heavy nuclei where the thickness of the diffused edge is relatively small, a certain sharp effective surface can be defined which characterizes the shape of the nucleus, and it can be considered as a collective dynamic variable. It is shown that the problem of fluid dynamics can be simplified by reducing it to simple linearized equations for the dynamics in the nuclear interior and boundary conditions set at the effective dynamic sharp surface of the density distribution. These conditions are derived from the fluid dynamical equations. Transitional densities obtained from this simple model are compared with the numerical solution of fluid dynamical equations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01415634
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  • 10
    Electronic Resource
    Electronic Resource
    Semiclassical calculations with nuclear model potentials in the ħ-resummation approach (1984)
    Springer
    The European physical journal 315 (1984), S. 341-347 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The single-particle densityρ(r) of a system of fermions can be calculated in a tractable way as the Laplace inverse of the Bloch density describing the system. The complex integrals involved can be solved very easily by the saddle-point method. The semiclassical nature of this approach is illustrated in the simple example of the single-particle level density of a harmonic oscillator potential. It is then applied to calculate the total energy of particles in different mean field potentials. The exact Bloch density being generally unknown, different approximate forms are used in our calculations which correspond to a partial resummation of the Wigner-Kirkwoodħ-expansion. The resulting local densities reproduce the exact density distributions on the average, without quantal oscillations. They are well defined everywhere, even beyond the classical turning point, in contrast to the original Wigner-Kirkwood approach.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01438459
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