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  • 2020-2022  (523)
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  • 1
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    Naegleria fowleri: Protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba (2021)
    Public Library of Science
    Details
    Publication Date: 2021-03-24
    Description: Naegleria fowleri is a pathogenic, thermophilic, free-living amoeba which causes primary amebic meningoencephalitis (PAM). Penetrating the olfactory mucosa, the brain-eating amoeba travels along the olfactory nerves, burrowing through the cribriform plate to its destination: the brain’s frontal lobes. The amoeba thrives in warm, freshwater environments, with peak infection rates in the summer months and has a mortality rate of approximately 97%. A major contributor to the pathogen’s high mortality is the lack of sensitivity of N. fowleri to current drug therapies, even in the face of combination-drug therapy. To enable rational drug discovery and design efforts we have pursued protein production and crystallography-based structure determination efforts for likely drug targets from N. fowleri. The genes were selected if they had homology to drug targets listed in Drug Bank or were nominated by primary investigators engaged in N. fowleri research. In 2017, 178 N. fowleri protein targets were queued to the Seattle Structural Genomics Center of Infectious Disease (SSGCID) pipeline, and to date 89 soluble recombinant proteins and 19 unique target structures have been produced. Many of the new protein structures are potential drug targets and contain structural differences compared to their human homologs, which could allow for the development of pathogen-specific inhibitors. Five of the structures were analyzed in more detail, and four of five show promise that selective inhibitors of the active site could be found. The 19 solved crystal structures build a foundation for future work in combating this devastating disease by encouraging further investigation to stimulate drug discovery for this neglected pathogen.
    Electronic ISSN: 1932-6203
    Topics: Medicine , Natural Sciences in General
    Published by Public Library of Science
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    PAPER CURRENT
  • 2
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    Extent and cessation of the mid-Cretaceous Hikurangi Plateau underthrusting: Impact on global plate tectonics and the submarine Chatham Rise (2020)
    Wiley
    In:  EPIC3Journal of Geophysical Research-Solid Earth, Wiley, 125, ISSN: 0148-0227
    Details
    Publication Date: 2020-08-21
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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  • 3
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    Extent and Cessation of the Mid-Cretaceous Hikurangi Plateau Underthrusting: Impact on Global Plate Tectonics and the Submarine Chatham Rise (2021)
    Details
    Publication Date: 2021-07-27
    Description: Subduction of oceanic plateaux are events that have occurred infrequently in Earth's history. Although rare, these events are thought to considerably influence regional tectonics and global plate motions. In the mid-Cretaceous the oceanic Hikurangi Plateau collided with the formerly active East Gondwana margin: An event which falls into the same of a sudden change from subduction to extensional processes, including graben formation, development rift basin development, and exhumation of metamorphic core complexes in the Zealandia continent as well as a global-scale plate reorganization event. In this study, we use recently acquired seismic refraction and gravity data along one profile across the submarine Chatham Rise, which represent a former accretionary wedge of the East Gondwana subduction zone. We demonstrate that the southward extent of the subducted Hikurangi Plateau in the lower crust beneath the submarine Chatham Rise along our profile is only ~150. This is ~150 km less than the previously suggested extent. Furthermore, we interpret that a slice of the subducted Phoenix Plate remains attached to the southern edge of the Hikurangi Plateau. We suggest that cessation of subduction in response to the Hikurangi Plateau jamming as well as the rollback and detachment of the Phoenix Plate slab played an important role in the changing tectonic forces across Zealandia in mid-Cretaceous. Moreover, we suggest that the subduction cessation along the Hikurangi Plateau segment led to the fragmentation of the Gondwana subduction zone and Phoenix Plate, which significantly influenced and potentially prolonged the global mid-Cretaceous plate reorganization event.
    Keywords: 551.136 ; Chatham Rise ; accretionary wedge ; Hikurangi Plateau ; oceanic plateau ; Zealandia ; refraction seismics
    Language: English
    Type: article
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    CITATION GEO-LEO
  • 4
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    Ecotypic variation and predatory behavior among killer whales (Orcinus orca) off the eastern Aleutian Islands, Alaska (2021)
    In:  http://aquaticcommons.org/id/eprint/8907 | 403 | 2012-06-18 09:30:42 | 8907 | United States National Marine Fisheries Service
    Details
    Publication Date: 2021-06-29
    Description: From 2001 to 2004 in the eastern Aleutian Islands, Alaska,killer whales (Orcinus orca) were encountered 250 times during 421 days of surveys that covered a total of 22,491 miles. Three killer whale groups (resident, transient, and offshore) were identified acoustically and genetically. Resident killer whales were found 12 times more frequentlythan transient killer whales, and offshore killer whales were encountered only once. A minimum of 901photographically identified resident whales used the region during our study. A total of 165 mammal-eating transient killer whales were identified, and the majority (70%) wereencountered during spring (May and June). The diet of transient killer whales in spring was primarily gray whales (Eschrichtius robustus), and in summer primarily northern fur seals (Callorhinus ursinus). Steller sea lions (Eumetopias jubatus) did not appear to be a preferred prey or major prey item during spring and summer. The majority of killer whales in the eastern Aleutian Islands are the resident ecotype, which does not consume marine mammals.
    Keywords: Biology ; Ecology ; Fisheries
    Repository Name: AquaDocs
    Type: article , TRUE
    Format: application/pdf
    Format: application/pdf
    Format: 74-87
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  • 5
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    Length-weight relationships of two Serranids and a Lutjanid caught off Nevis, West Indies (2021)
    In:  http://aquaticcommons.org/id/eprint/13305 | 9596 | 2014-01-22 19:20:02 | 13305 | Gulf and Caribbean Fisheries Institute
    Details
    Publication Date: 2021-06-26
    Keywords: Fisheries ; GCFI
    Repository Name: AquaDocs
    Type: conference_item
    Format: application/pdf
    Format: application/pdf
    Format: 155-164
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  • 6
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    Studies of the age, growth, sexual maturity and spawning of populations of anchoveta (Cetengraulis mysticetus) of the coast of the Eastern Tropical Pacific Ocean (2021)
    In:  http://aquaticcommons.org/id/eprint/2448 | 8 | 2011-09-29 19:04:02 | 2448 | Inter-American Tropical Tuna Commission
    Details
    Publication Date: 2021-07-13
    Description: ENGLISH: Three hundred and twenty-six collections of anchoveta (Cetengraulis mysticetus), an important tuna bait species, taken between April 1951 and April 1960 from seven major baiting areas in the Eastern Tropical Pacific Ocean (Almejas Bay, Guaymas, Ahome Point, Banderas Bay, Gulf of Fonseca, coast of Colombia and Ecuador-Peru) are the basis of this study of age, growth, sexual maturity and spawning. The study of the temporal progression of modal size groups from plots of monthly length-frequency distributions provided estimates of age and rate of growth. The study of sexual maturity and time of spawning was based on gross examination of ovaries, and application of the gonad index.SPANISH: Trescientas veintiseis recolecciones de anchovetas (Cetengraulis mysticetus), una importante especie de carnada para la pesca del atún, cogidas entre abril de 1951 y abril de 1960 en siete de las mayores áreas de pesca de peces de carnada en el Océano Pacífico Oriental Tropical (Bahía de Almejas, Guaymas, Punta Ahome, Bahía Banderas, Golfo de Fonseca, y las costas de Colombia y de Ecuador- Perú), sirven de base a este estudio de la edad, crecimiento, madurez sexual y desove de dicha especie. El estudio de la progresión temporal de los grupos de tamaños modales según los gráficos de las distribuciones de la frecuencia de las longitudes proporcionó estimaciones de la edad y de la tasa de crecimiento. La investigación de la madurez sexual y la época de desove se basó en el examen macroscópico de los ovarios y en la aplicación del índice de gónadas.
    Description: This article is bilingual and contains both Spanish and English translations.
    Keywords: Fisheries ; Biology ; age ; growth ; sexual maturity ; spawning ; anchoveta ; Cetengraulis mysticetus ; edad ; crecimiento ; madurez sexual ; desove
    Repository Name: AquaDocs
    Type: article
    Format: application/pdf
    Format: application/pdf
    Format: 113-216
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  • 7
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    Blood lactate in yellowfin tuna, Neothunnus macropterus, and skipjack, Katsuwonus pelamis, following capture and tagging (2021)
    In:  http://aquaticcommons.org/id/eprint/2576 | 8 | 2011-09-29 18:54:43 | 2576 | Inter-American Tropical Tuna Commission
    Details
    Publication Date: 2021-06-25
    Description: ENGLISH: The staff of the Inter-American Tropical Tuna Commission for several years has been investigating the life history, population structure, behavior and ecology of the yellowfin tuna, Neothunnus macropterus, and the skipjack, Katsuwonus pelamis, in the Eastern Tropical Pacific Ocean. The tagging and subsequent recovery of these tropical tunas, to provide information on population structure, migrations, mortality rates and growth rates, are important aspects of these investigations. Broadhead (1959) and Schaefer, Chatwin and Broadhead (1961) emphasize the many difficulties involved in tagging these extremely active yet delicate fish and give considerable evidence to suggest that tagging mortality is high, perhaps as great as 60 to 80 per cent. The latter authors suggest that the rather high mortality at tagging is related to the effects of hyperactivity brought about by the tagging operation.SPANISH: El personal de la Comisión Interamericana del Atún Tropical ha estado investigando durante varios años la historia natural, la estructura de la población, los hábitos y la ecología del atún aleta amarilla, Neothunnus macropterus, y del barrilete, Katsuwonus pelamis, en el Océano Pacífico Oriental Tropical. La marcación y el subsiguiente recobro de estos atunes tropicales, lo que da información sobre la estructura de la población, los movimientos migratorios y las tasas de crecimiento y de mortalidad, son importantes aspectos de estas investigaciones. Broadhead (1959) y Schaefer, Chatwin y Broadhead (1961) destacan las muchas dificultades que hay para marcar estos peces activos en extremo pero delicados, y proporcionan considerable evidencia que sugiere que la mortalidad por la marcación es bastante alta, siendo quizás de 60 a 80 por ciento. Los autores citados sugieren que esta elevada mortalidad por la marcación está relacionada con los efectos de la hiperactividad producida por la operación de marcación.
    Description: This article is bilingual and contains both Spanish and English translations.
    Keywords: Fisheries ; Biology ; blood lactate ; yellowfin tuna ; Neothunnus macropterus ; skipjack ; Katsuwonus pelamis ; lactate en la sangre
    Repository Name: AquaDocs
    Type: article
    Format: application/pdf
    Format: application/pdf
    Format: 231-280
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  • 8
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    Some factors affecting the distribution and apparent abundance of yellowfin and skipjack tuna in the Eastern Pacific Ocean (2021)
    In:  http://aquaticcommons.org/id/eprint/2618 | 8 | 2011-09-29 18:47:49 | 2618 | Inter-American Tropical Tuna Commission
    Details
    Publication Date: 2021-06-26
    Description: ENGLISH: Since 1951, the Inter-American Tropical Tuna Commission has been investigating the biology, ecology and population dynamics of the yellowfin tuna, Thunnus albacares, and the skipjack tuna, Katsuwonus pelamis, in the Eastern Pacific Ocean. Of particular importance has been the study of the effects of fishing and of fishery-independent factors on the abundance and distribution of these tunas. For yellowfin tuna there is, on the average, an inverse relationship between total fishing effort and apparent abundance (Schaefer, 1957a). For skipjack there is no evidence to suggest that fishing effort has ever been sufficiently intense to affect measurably the abundance (Schaefer, 1961). Rather, it appears that the year-to-year fluctuations in apparent abundance are independent of the activities of the fishing fleets.SPANISH: Desde 1951 la Comisión Interamericana del Atún Tropical se ha dedicado a la investigación de la biología, ecología y la dinámica de las poblaciones del atún aleta amarilla, Thunnus albacares, y del barrilete, Katsuwonus pelamis, en el Océano Pacífico del Este. De importancia especial ha sido el estudio de los efectos de la pesca y de los factores independientes de las pesquerías sobre la abundancia y la distribución de esos atunes. En cuanto al atún aleta amarilla, existe, en promedio, una relación inversa entre el esfuerzo total de pesca y la abundancia aparente (Schaefer, 1957a) . Con respecto al barrilete, no hay evidencia que haga pensar que el esfuerzo de pesca haya sido nunca lo suficientemente intenso como para afectar sensiblemente la abundancia (Schaefer, 1961). Más bien parece que las fluctuaciones de un año a otro en su abundancia aparente, son independientes de las actividades de las flotas pesqueras.
    Description: This article is bilingual and contains both Spanish and English translations.
    Keywords: Fisheries ; distribution ; abundance ; yellowfin tuna ; Thunnus albacares ; skipjack tuna ; Katsuwonus pelamis ; Eastern Pacific Ocean ; distribución ; abundancia ; atún aleta amarilla ; barrilete ; Océano Pacífico Oriental
    Repository Name: AquaDocs
    Type: article
    Format: application/pdf
    Format: application/pdf
    Format: 417-474
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  • 9
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    Muscle glycogen and blood lactate in yellowfin tuna, Thunnus albacares, and skipjack, Katsuwonus pelamis, following capture and tagging (2021)
    In:  http://aquaticcommons.org/id/eprint/3012 | 8 | 2011-09-29 18:04:13 | 3012 | Inter-American Tropical Tuna Commission
    Details
    Publication Date: 2021-06-30
    Description: ENGLISH: Tagging and the recovery of tagged yellowfin (Thunnus albacares) and skipjack(Katsuwonus pelamis) tunas are important aspects of the investigations conducted by the Inter-American Tropical Tuna Commission in the Eastern Tropical Pacific Ocean. The results of the tagging program provide information on population structures, migrations, mortality rates and growth rates of these two species. The present experimental program was undertaken to study the relationship between muscular fatigue and high tagging mortalities in yellowfin and skipjack.SPANISH: La marcación del atún aleta amarilla (Thunnus albacares) y del barrilete (Katsuwonus pelamis), y el recobro de estos atunes marcados, son aspectos importantes de la investigación que efectúa la Comisión Interamericana del Atún Tropical en el Océano Pacífico Oriental Tropical. Los resultados del programa de marcación proporcionan información sobre la estructura de las poblaciones,migraciones, tasas de mortalidad y tasas de crecimiento de estas dos especies. El programa experimental presente fue emprendido para estudiar la relación entre la fatiga muscular y la alta mortalidad causada por la marcación en el atún aleta amarilla y el barrilete.(PDF contains 52 pages.)
    Description: This article is bilingual and contains both Spanish and English translations.
    Keywords: Fisheries ; muscle ; glycogen ; lactate ; yellowfin tuna ; Thunnus albacares ; skipjack ; Katsuwonus pelamis ; capture ; tagging ; glicógeno ; músculos ; lactato ; atún aleta amarilla ; Thunnus albacares ; barrilete ; Katsuwonus pelamos ; captura ; marcación
    Repository Name: AquaDocs
    Type: article
    Format: application/pdf
    Format: application/pdf
    Format: 217-268
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  • 10
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    Artificial fertilization of the eggs, and rearing and identification of the larvae of the anchoveta, Cetengraulis mysticetus (2021)
    In:  http://aquaticcommons.org/id/eprint/2581 | 8 | 2011-09-29 18:55:20 | 2581 | Inter-American Tropical Tuna Commission
    Details
    Publication Date: 2021-06-25
    Description: ENGLISH: The anchoveta, Cetengraulis mysticetus (Günther), is an important bait fish used to capture tunas in the Eastern Tropical Pacific Ocean. Contributions to the early life history of this species in the Gulf of Panama were made by Simpson (1959), who was able to identify deductively the planktonic egg of the anchoveta from 10 other anchovy eggs concurrently present. He also reared these planktonic eggs in the laboratory and described the resultant larvae to the age of 48 hours after hatching. Because of the lack of differences among the anchovy larvae, this description does not permit the identification of anchoveta larvae from those of other engraulid species. Furthermore, while adult specimens are easily recognized, up to the present it has not been possible to extend the identification of the juvenile anchoveta to specimens smaller than about 25 mm. The purpose of this study, therefore, was to identify anchoveta from the time of hatching to about 25 mm. SPANISH: La anchoveta, Cetengraulis mysticetus (Günther), es un importante pez de carnada que se emplea en la captura de los atunes en el Océano Pacífico Oriental Tropical. Simpson (1959) logró identificar deductivamente el huevo planctónico de la anchoveta al separarlo de otros diez huevos de anchoas que se encuentran al mismo tiempo, contribuyendo de esta manera a conocer los primeros estados de la historia natural de esta especie en el Golfo de Panamá. El también estableció un criadero en el laboratorio con estos huevos planctónicos y describió las larvas resultantes hasta la edad de 48 horas después de la eclosión. Debido a que no hay diferencias entre las larvas de las anchoas, esta descripción no permite identificar las larvas de la anchoveta de las otras especies de engráulidos. Más aun, a pesar de que los especímenes adultos son fácilmente reconocibles, hasta ahora no ha sido posible identificar la anchoveta juvenil de menos de unos 25 mm. Consecuentemente, el propósito del presente estudio ha sido el de identificar al anchoveta desde el momento de la eclosión hasta que tiene unos 25 mm.
    Description: This article is bilingual and contains both Spanish and English translations.
    Keywords: Fisheries ; Biology ; artificial fertilization ; rearing ; identification of larvae ; anchoveta ; Cetengraulis mysticetus ; fertilización artificial ; crianza ; identificación de larvas
    Repository Name: AquaDocs
    Type: article
    Format: application/pdf
    Format: application/pdf
    Format: 153-178
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