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  • Springer  (3)
  • 2020-2022  (3)
  • 1
    Publication Date: 2020-05-05
    Print ISSN: 0171-6468
    Electronic ISSN: 1436-6304
    Topics: Mathematics , Economics
    Published by Springer
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  • 2
    Publication Date: 2020-07-27
    Description: In outpatient chemotherapy, nurses administer the drugs in two steps. In the first few minutes of each appointment, a nurse prepares the patient for infusion (drug administration). During the remainder of the appointment, the patient is monitored by nurses and if needed taken care of. One nurse must be assigned to prepare the patient and set up the infusion device. However, a nurse who is not busy setting up may simultaneously monitor up to a certain number of patients who are already receiving infusion. The prescribed infusion durations are significantly different among the patients on a day at a clinic. We formulate this problem as a multi-criterion mixed integer program. The appointments should be scheduled with start times close to patients’ ready times, balanced workload among nurses, few nurse changes during appointments, and few nurse full-time equivalent (FTE) assigned to the schedule of the day. As the number of nurse FTEs is an output of the model rather than a fixed input, the clinic can use the nursing capacity more efficiently, i.e., with less labor cost. We develop a 3-stage heuristic for finding criterion points with the minimum weighted average deferring time of appointments for the minimum feasible number of nurse FTEs or a desired value above that. By not constraining the number of chairs or beds, we can find solutions with better (dominating) criterion points. Drug preparation, oncologist visit, and the laboratory test can be scheduled based on the drug administration appointment start time. Thus, the drug administration resources are efficiently used with desirable performance in taking the interests and requirements of various stakeholders into consideration: patients, nurses, oncologists, pharmacy, and the clinic.
    Print ISSN: 0171-6468
    Electronic ISSN: 1436-6304
    Topics: Mathematics , Economics
    Published by Springer
    Location Call Number Expected Availability
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  • 3
    Publication Date: 2020-09-24
    Description: Main conclusion Stomatal aperture in maize is not affected by exposure to a subtoxic concentration of atmospheric H2S. At least in maize, H2S, thus, is not a gaseous signal molecule that controls stomatal aperture. Abstract Sulfur is an indispensable element for the physiological functioning of plants with hydrogen sulfide (H2S) potentially acting as gasotransmitter in the regulation of stomatal aperture. It is often assumed that H2S is metabolized into cysteine to stimulate stomatal closure. To study the significance of H2S for the regulation of stomatal closure, maize was exposed to a subtoxic atmospheric H2S level in the presence or absence of a sulfate supply to the root. Similar to other plants, maize could use H2S as a sulfur source for growth. Whereas sulfate-deprived plants had a lower biomass than sulfate-sufficient plants, exposure to H2S alleviated this growth reduction. Shoot sulfate, glutathione, and cysteine levels were significantly higher in H2S-fumigated plants compared to non-fumigated plants. Nevertheless, this was not associated with changes in the leaf area, stomatal density, stomatal resistance, and transpiration rate of plants, meaning that H2S exposure did not affect the transpiration rate per stoma. Hence, it did not affect stomatal aperture, indicating that, at least in maize, H2S is not a gaseous signal molecule controlling this aperture.
    Print ISSN: 0032-0935
    Electronic ISSN: 1432-2048
    Topics: Biology
    Published by Springer
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