Wiley InterScience Backfile Collection 1832-2000
Chemistry and Pharmacology
The complex formation of cis- and trans-1,2-Diaminocyclohexan with the ions H+, Co2+, Ni2+, Cu2+, Zn2+, Cd2+ has been studied. The metal complexes of the trans-diamine are slightly more stable than the corresponding complexes of ethylenediamine, which is probably due to a somewhat more positive entropy term of the formation reaction. The complexes of the cis-compound are somewhat less stable than those of the trans-diamine. The distance between the two basic nitrogen atoms are almost certainly the same in both diamine molecules. The cis-compound, however, has a less favourable geometry for complex formation, because the chelate ring and the 6-membered carbon ring do not lie in the same plane as will be the case with the complexes of the trans-diamine.
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