Springer Online Journal Archives 1860-2000
Chemistry and Pharmacology
Abstract To elucidate the mechanisms involved in the regulation of uricase activity in Drosophila melanogaster, a comparative analysis of the patterns of uricase activity during development was undertaken for the wild type, Ore-R, and the mutants ry 2 and ma-1. Uricase activity in ry 2 and ma-l, unlike that in Ore-R, increased rapidly following emergence of the adult. This study indicates that uricase in Drosophila, in contrast to that in several microorganisms, is not induced by uric acid, since ry 2 and ma-l with no detectable uric acid have higher activity than the wild type.
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