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  • 1
    ISSN: 1432-1041
    Keywords: frusemide ; piretanide ; variance comparison ; regularity of effect ; activity comparison ; drug excretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Comparison of variances can be useful in assessing the regularity of drug effects. In order to compare the variances of the saluretic effects of piretanide and frusemide, two loop diuretics with different bioavailabilities, a double-blind cross-over study was carried out in 34 normal volunteers. The diuretics were given in randomized order, with an interval of 7 days, in single equipotent doses (frusemide 6.25 mg and piretanide 1.0 mg chosen from previous results) adjusted by body weight. The dispersion of individual values (comparison of variances from paired measures) for Na+, Cl− and Ca++ excretion, urine osmolality and excretion of the drugs, was significantly smaller for piretanide than for frusemide. It is concluded that the saluretic effect of a single dose of piretanide varies less than that of an equipotent dose of frusemide. The methodology may be useful in trials of drugs for which regularity of effect is important.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-234X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The topography of the funnel-canal organs of Carcinus maenas (Decapoda, Crustacea) and their stimulus-receiving cuticular and sensory apparatus were studied in the light and electron microscopes. About 4000 funnel-canal organs are situated within the exoskeleton of Carcinus. Almost all of them are on the distal segments of the walking legs, in particular on the epicuticular cap at the tip of the dactyl. They were not found to be arranged in groups or sensilla fields, and no sex-specific differences were observed. Characteristic features of the funnel-canal organs are as follows: (a) There is a terminal pore (0.5×0.8 μm diameter) in the cuticle, at the tip of a small projection. It is closed by a plug of electron-dense material. (b) The terminal sections of the dendrites are enclosed in a dendritic sheath up to ca. 10 μm below the pore. (c) The dendrites, 3–24 in number, end below the plug; none of the dendrites exhibits a tubular body; two of the dendrites are distinguished from the others by the greater number of microtubules in their outer segments. The structural characteristics, in particular the “gustatory pore” and the number of dendrites, are typical of bimodal receptors in arthropods. In such receptors, as in the contact chemoreceptors of insects and arachnids, mechano-and chemosensitive sensory cells are combined. This interpretation of the function of the funnel-canal organs is supported by electrophysiological data of other authors. The morphological parameters we find for the funnelcanal organs, in comparison with those of insect campaniform sensilla, provide clear evidence against the reclassification of the funnel-canal organs as “crustacean campaniform organs” proposed by Shelton and Laverack (1968).
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Applied physics 28 (1982), S. 211-214 
    ISSN: 1432-0630
    Keywords: 78.35 ; 68.30
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract In the experiments reported here we observed the generation of non-thermal, large amplitude acoustic surface waves at GHz frequencies on the surface of a GaAs crystal under intense illumination with 514.5 nm radiation from an Ar+ laser at room temperature. The acoustic surface waves were detected by optical Brillouin spectroscopy.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-0649
    Keywords: 85.60
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
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  • 5
    Publication Date: 2019-03-04
    Description: The boron isotope (δ11B) composition of marine calcifiers is considered to be one of the most reliable pH proxies, enabling us to reconstruct past ocean pH and infer on the associated changes in carbon budget involved (e.g. Gut- jahr et al. 2017). The application of the commonly used δ 11 B archives such as foraminifera or corals is however mostly limited to the Cenozoic due to insufficient preservation or incomplete geological records. Brachiopods have a promising potential for extending our knowledge on seawater pH evolution throughout the entire Phanerozoic considering their high abundance in the fossil record and its origin dating back to the early Cambrian. Moreover, their shell is composed of low-magnesium calcite, rendering brachiopods more resistant to post-depositional di-magenetic alteration of its primary chemical signal (e.g. Brand et al. 2012). Additionally, even today they present an extant and widespread taxa, allowing for an assessment of the controls on boron isotope incorporation into brachiopod calcite and possible distortions of the signal due to vital effects or other processes. We present a detailed exploration of boron isotope systematics in three different brachiopod species (Magellania venosa, Terebratella dorsata, Pajaudina atlantica) cultured under controlled laboratory settings for over a year. Our experimental setup includes a control (pH = 8.15) and two pH treatments (pH = 7.6 and 7.35), and we provide both bulk MC-ICP-MS as well as high spatial resolution SIMS data of the shell material. Our results indicate that boron incorporation is primarily driven by vital effects related to their ability to regulate calcifying fluid pH in response to ambient changes, which we further validate by in vivo microelectrode measurements (e.g. Stumpp et al. 2012). Despite internal buffering, the local pH at calcification sites systematically decreases with seawater pH, and hence is impacted by ocean acidification. This not only suggests that brachiopod shells serve as useful and conservative recorders of past ocean pH trends, but also provides new insights into mechanisms that may have enabled brachiopod survival throughout several major environmental crises in the past. Our findings have implications for past climate studies, as well as research on calcification processes and physio- logical adaptations to environmental change (e.g. the actual global ocean acidification). Brand, U., Posenato, R., Came, R., Affek, H., Angiolini, L., Azmy, K. and Farabegoli, E., 2012. The end-Permian mass extinction: A rapid volcanic CO2 and CH4-climatic catastrophe, Chem. Geol. 323, 121-144. Gutjahr M., Ridgewell A., Sexton P.F., Anagnostou E., Pearson P.N., Pälike H., Norris R.D., Thomas E., and Foster G.L., 2017. Very large release of mostly volcanic carbon during the Palaeocene-Eocene Thermal Maximum, Nature 548, 573-577. Stumpp M., Hu M.Y., Melzner F., Gutowska M., Dorey N., Himmerkus N., Holtmann W.C., Dupont S.T., Thorndyke M.C., and Bleich M. Acidified seawater impacts sea urchin larvae pH regulatory systems relevant for calcification, PNAS 44: 18192-18197.
    Type: Conference or Workshop Item , NonPeerReviewed
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  • 6
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Selective laser excitation was used to measure the radiative lifetimes of the ZnI triplet states 4sns 3 S 1(n=5–7) and 4snd 3 D 3,3 D 2 and3 D 1(n=4–6). These states were excited from the metastable 4s4p 3 P states, which were collisionally populated in an atomic beam. The values are compared with the results of other experimental methods (beam-foil, pulsed electron excitation, Hanle effect) and with theoretical calculations. The corresponding oscillator strengths are discussed with respect to the astrophysical determination of the Zn photospheric abundance.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract It is shown how for temperatures below the critical one (Tc≈20 MeV) the phase diagram of hot nuclear matter may be reconstructed by using experimentally determined cluster abundances from nucleus-nucleus collisions.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1434-6036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Recently photochemical holeburning experiments have been carried out in organic glasses down to 0.4 K. Here we give a theoretical explanation of theT 1.3-dependence of the holewidth. It is based on the strain field coupling between impurity molecules and two-level tunneling states leading to a kind of “spectral diffusion” of the optical excitation energy.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 16 (1983), S. 347-352 
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The extended technicolor modelSU(8) ⊃SU(5)×SU(3) c ×U(1)⊃SU TC(3)×SU w(2)×SU c(3) ×U(1) with fermion representations containing three quark lepton families attracts attention because of its unique technicolor coupling: it increases in the infrared circumventing a no-go theorem and further-more stays big over the whole technicolor range. Hence an enhancement of fermion and pseudogoldstone masses proposed by Holdom might happen, allowing for a large sideways scale. A scalar field in the 1015 GeV range introduced in order to break an exact global flavour symmetry of the model is argued to influence strongly the vacuum alignment in the technicolor sector. It permits an explanation of the quark lepton mass pattern even with-out a detailed fit.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 25 (1984), S. 45-48 
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Instantons infinitesimally turned out of theSU c (3) subspace of spontaneously brokenSU(5) gauge theory induce a baryon number violating interaction proportional 1/μ X 2 like heavy vector boson exchange, but with a different tensor structure.
    Type of Medium: Electronic Resource
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