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  • 1
    Unknown
    Duesseldorf : Data Becker
    Call number: 92-0026
    Pages: 1113 S. mit Diskette ; 24 cm
    ISBN: 3890113559
    Series Statement: Data Becker 355
    Branch Library: AWI Library
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  • 2
    ISSN: 1432-0983
    Keywords: Mitochondria ; Ribosomal protein ; Nuclear gene ; pet mutant ; yeast
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The Saccharomyces cerevisiae nuclear gene MRP-L6 was cloned by complementation of the respiratory-deficient mutant pet-ts 2523 with a library of wildtype yeast genomic DNA. The isolated gene was part of a 3.8-kb sequenced DNA fragment containing, in addition to MRP-L6, two unassigned reading frames, ORF1 and ORF2. MRP-L6 codes for a basic protein of 205 amino acids and a molecular mass of 22.8 kDa. The protein exhibits significant sequence similarity to the ribosomal protein L6 of bacteria and chloroplasts. Unlike the corresponding bacterial proteins, however, the MRP-L6 protein (MRP-L6p) contains at its N-terminus a 16 amino-acid leader sequence exhibiting the known characteristics of mitochondrial import signals. Disruption of MRP-L6 leads to the phenotype of a mitochondrial translation-defective, rho-negative yeast mutant. The results are consistent with MRP-L6p representing an essential component of yeast mitochondrial ribosomes. Expression of MRP-L6 was examined, under conditions of glucose repression and derepression, in wild-type cells and in a series of catabolite repression-defective yeast mutants. In most cases, a distinct though small influence of the carbon source on the expression of an MRP-L6/lacZ reporter construct was observed.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-2242
    Keywords: RFLP marker ; Barley ; Powdery mildew ; Mla locus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary To identify the mildew resistance locus Mla in barley with molecular markers, closely linked genomic RFLP clones were selected with the help of near-isogenic lines having the ‘Pallas’ and ‘Siri’ background. Out of 22 polymorphic clones 3 were located around the Mla locus on chromosome 5 with a distance of 5.1 + 2.9 cM (MWG 1H068), 4.2±1.7 cM (MWG 1H060) and 0.7 ± 0.7 cM (MWG 1H036), respectively. The polymorphic clone MWG 1H036 displayed the same RFLP pattern in both ‘Pallas’ and ‘Siri’ near-isogenic lines and in different varieties digested with six restriction enzymes possessing the same mildew resistance gene. The alleles of the Mla locus were grouped in 11 classes according to their specific RFLP patterns; 3 of these groups contain the majority of Mla alleles already used in barley breeding programs in Europe.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-2242
    Keywords: Barley ; Multigene family ; Mla locus ; Recombination ; RFLP marker
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The complex structure of the multigene family at the Mla locus conferring powdery mildew resistance in barley was studied by making diallel crosses between several near-isogenic lines carrying different Mla alleles. The mode of inheritance of the Mla alleles investigated was determined to be dominant for Mla1, Mla6, Mla7 and Mla13 and semidominant for Mla3, Mla12 and Mla20. F1 plants were backcrossed to the susceptible recurrent parent in order to identify susceptible and double-resistant recombinants in the BC1F1 generation. Out of 17605 progenies tested in the BC1F1 generation, two susceptible recombinants, one between Mla1 and Mla12 and one between Mla13 and Mla20 were confirmed. The former was also verified by RFLP analysis.
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  • 5
    ISSN: 1432-0983
    Keywords: Saccharomyces cerevisiae ; Fructose-1,6-bisphosphatase ; Glucose repression ; Gene activation ; Gluconeogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Fructose-1,6-bisphosphatase is a key enzyme in gluconeogenesis and the FBP1 gene is not transcribed during growth with glucose. Genetic analysis indicated a positive regulation of FBP1 expression after exhaustion of glucose. By linker-deletion analysis, two upstream activation sites (UAS1 and UAS2) were localized and the respective UAS-binding factors (DAP I and DAP II for derepression activating protein) were identified by gel retardation. UAS1 and UAS2 span about 30 bp each, and are separated by approximately 30 bp. Both UAS sites act synergistically. Although UAS1 showed some similarities to the DNA-binding consensus for the general yeast activator Rap1, competition experiments and DEAE-chromatography proved that DAP I and Rap1 correspond to different proteins. Gel retardation by DAP I depended on carbon sources and did not occur in cells growing logarithmically with glucose, whereas a strong retardation signal was obtained with ethanol-grown cells. The present results suggest that DAP I and DAP II are the final regulatory elements for glucose derepression.
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  • 6
    ISSN: 1432-0983
    Keywords: Saccharomyces cerevisiae ; Isocitrate lyase ; Gene regulation ; Ethanol induction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The ICL1 gene encoding the isocitrate lyase from Saccharomyces cerevisiae was cloned and sequenced. A reading frame of 557 amino acids showing significant similarity to isocitrate lyases from seven other species could be identified. Construction of icl1 null mutants led to growth defects on C2 carbon sources while utilization of sugars or C3 substrates remained unaffected. Using an ICL1-lacZ fusion integrated at the ICL1 locus, a more than 200-fold induction of β-galactosidase activity was observed after growth on ethanol when compared with glucose-repressed conditions. A preliminary analysis of the ICL1 upstream region identified a 364-bp fragment necessary and sufficient for this regulatory phenotype. Sequence motifs also present in the upstream regions of co-regulated genes were found within this region.
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  • 7
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A Rutherford scattering diagnostic has been applied at the TEXTOR tokamak to obtain spatially and temporally resolved information on the temperature of the bulk ions in the plasma. In the experimental setup, a helium atomic beam (30-keV, 12-mA equivalent current) passes vertically through the plasma core. A small part of the injected atoms is scattered elastically by the thermally moving plasma ions. The ion temperature in the scattering volume can be determined from the broadening of the energy spectrum of the scattered particles. Energy analysis of the scattered atoms is performed by a mass-selective time-of-flight analyzer detecting the particles at an observation angle which is selectable between 3° and 8°. Coincidence techniques have been successfully applied in this detector for rejection of background events triggered by detections of neutrons and gamma radiation. Ion temperature profiles were measured on a shot-to-shot basis by shifting the cross section of the diagnostic beam and the observational volume of the analyzer through the plasma. The ion temperatures measured in ohmic deuterium plasmas were found to be in reasonable agreement with those obtained from passive neutral particle analysis. Up to now, ion temperatures have been measured throughout the complete discharge with an accuracy of 8% and a time and space resolution of 100 ms and 0.10 m at a scattering angle of 7°. Deuteron density profiles could be deduced from the scattering yield measured at different radial positions in the plasma. The ratio of the isotopes, hydrogen and deuterium, was determined from their separate contributions to the spectrum of helium particles scattered on hydrogen and deuterium. Although theoretical predictions showed that the majority of the probing helium atoms loses one of its electrons during the elastic scattering process on multiply charged carbon and oxygen ions, contributions from impurities to the observed experimental spectrum are shown to appear dominant for impure plasmas.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1520-5002
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1573-0646
    Keywords: pirarubicin ; anthracycline ; breast cancer ; phase II trial
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In a phase II study, 77 patients with metastatic breast cancer were treated with pirarubicin, 70 mg/m2 iv every 3 weeks. Most of them had received prior hormonal (n = 39) and/or chemotherapeutic drug treatment for advanced disease, including anthracycline-containing regimens in 17. After a median of 5.5 treatment cycles (range 1–14), objective tumor response was seen in 22/71 (31%) evaluable patients (4CR, 18 PR). Stable disease occurred in 34 (48%) patients, whereas the tumor progressed in 15 (21%). Significant hematologic toxicity (WHO grade III–IV) requiring interval and/or dose adjustments was observed in 41 (58%) patients. Other treatment-related side effects were generally mild, and included alopecia in 52 (73%), nausea and/or emesis in 50 (70%), and stomatitis and diarrhea in 3 patients each. There was no treatment-related death, nor was there any evidence of cardiac toxicity thus far. In summary, the early results of this trial suggest that pirarubicin is an active and rather well tolerated drug in pretreated patients with advanced breast cancer.
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  • 10
    facet.materialart.
    Unknown
    de Gruyter
    In:  Botanica Marina, 37 . pp. 471-477.
    Publication Date: 2018-06-15
    Description: Fucus evanescens is recorded for the first time in Kiel Bight (western Baltic). It is now common at several sites in the lower zone of F. vesiculosus. Its arrival to the area and especially its increase in abundance seem to be recent. Epiphyte load in late spring was significantly higher on F. vesiculosus (20%) than on F. evanescens (5%). The immigration of F. evanescens from Danish waters may be connected to the decline in abundance of F. vesiculosus and F. serratus in the western Baltic.
    Type: Article , PeerReviewed
    Format: text
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