Resolution of atropisomers
Polychlorinated biphenyls (PCBs)
Dynamic gas chromatography
Analytical Chemistry and Spectroscopy
Wiley InterScience Backfile Collection 1832-2000
Chemistry and Pharmacology
Selectively alkylated cyclodextrins have been used to resolve the enantiomers of 2,2′ alkylated biphenyls. The configurational stability of 2,2′-dimethyl and 2,2′-diethyl biphenyls is insufficient for gas chromatographic separation even at ambient temperature. 2-Isopropyl-2′-t-butyl- and 2,2′-di-t-butylbiphenyl are configurationally stable under the conditions applied, whereas 2,2′-diisopropyl- and 2,2′-bis(trifluoromethyl)biphenyl show temperature-dependent interconversion of the enantiomers during chromatography. The gas chromatographic separation of the enantiomers of some ortho trichlorinated biphenyls carrying 4, 5, and 6 chlorine substituents has been demonstrated for the first time.
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