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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 213 (2002), S. 0 
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The detection of ancient microbial DNA offers a new approach for the study of infectious diseases, their occurrence, frequency and host–pathogen interaction in historic times and populations. Moreover, data obtained from skeletal and mummified tissue may represent an important completion of contemporary phylogenetic analyses of pathogens. In the last few years, a variety of bacterial, protozoal and viral infections have been detected in ancient tissue samples by amplification and characterization of specific DNA fragments. This holds particularly true for the identification of the Mycobacterium tuberculosis complex, which seems to be more robust than other microbes due to its waxy, hydrophobic and lipid-rich cell wall. These observations provided useful information about the occurrence, but also the frequency of tuberculosis in former populations. Moreover, these studies suggest new evolutionary models and indicate the route of transmission between human and animals. Until now, other pathogens, such as Mycobacterium leprae, Yersinia pestis, Plasmodium falciparum and others, have occasionally been identified – mostly in single case studies or small sample sizes – as well, although much less information is available on these pathogens in ancient settings. The main reason therefore seems to be the degradation and modification of ancient DNA by progressive oxidative damage. Furthermore, the constant risk of contamination by recent DNA forces to take time and cost effective measures and renders the analysis of ancient microbes difficult. Nevertheless, the study of microbial ancient DNA significantly contributes to the understanding of transmission and spread of infectious diseases, and potentially to the evolution and phylogenetic pathways of pathogens.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0143-991X
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The application of robotics in manufacturing industry is increasingly spreading to other fields such as service, security and medical, and more recently into orthopedic surgery. Most research projects to date have concentrated on the lighter side of non-invasive surgery, camera, laser guidance, light cutting and milling through bone. Just as in industrial production and processing applications, the choice of robot and its accompanying control and programming system is absolutely paramount. This simple fact has been justified in recent research dealing with the heavier forms of fracture repositioning robotics in accident surgery. This paper discusses the development of the complete system including robot, end-effector and sensors.
    Type of Medium: Electronic Resource
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  • 3
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    Frankfurt a. M.: European Central Bank (ECB)
    Publication Date: 2017-02-24
    Description: In this paper we analyse the interaction of fiscal rules and fiscal space. We find strong evidence for fiscal rules being associated with higher fiscal space. Furthermore, the analysis shows that countries with more fiscal space tend to have higher discretionary expenditures, but that this effect is significantly reduced if fiscal rules are in place. A similar effect can be observed for the procyclicality of fiscal policy, which is significantly higher in an environment of ample fiscal space, while this difference is reduced with fiscal rules. Regarding the different types of fiscal rules, we find the strongest results for expenditure rules and to a lesser extent for balanced budget rules, but none for debt rules.
    Keywords: E61 ; E62 ; H60 ; ddc:330 ; discretionary fiscal policy ; fiscal rules ; fiscal space ; procyclicality
    Repository Name: EconStor: OA server of the German National Library of Economics - Leibniz Information Centre for Economics
    Language: English
    Type: doc-type:workingPaper
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  • 4
    Publication Date: 2017-03-31
    Description: Official and unilateral dollarisation/euroisation has become a common policy advice for emerging market economies. Against this background, the paper provides a comprehensive review of all the main cases of dollarisation/euroisation, analysing motives, features and policy implications of this exchange rate regime. The main results are that policies fostering integration with the anchor country, in particular fiscal transfers, tourism and offshore finance, have been crucial in supporting the exchange rate regime. To this end, most dollarised/euroised countries have exploited advantages that are largely prior to the choice of exchange rate regime, namely their small size, geographic proximity to the anchor country, and politically dependent status. Thus, recommending dollarisation/euroisation irrespective of countries’ ex ante degree of integration with the potential anchor country seems to bear considerable risks, as dollarisation/euroisation does not seem to be a straightforward substitute for integration.
    Keywords: ddc:330 ; Währungssubstitution ; Euro ; US-Dollar ; Optimaler Währungsraum ; Welt
    Repository Name: EconStor: OA server of the German National Library of Economics - Leibniz Information Centre for Economics
    Language: English
    Type: doc-type:report
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  • 5
    Publication Date: 2017-03-31
    Description: This paper reviews the strategies announced by the ten countries joining the European Union in May 2004 with regard to their intentions for participation in ERM II and the adoption of the euro. The paper examines the economic rationale of the monetary integration strategies declared by most acceding countries with a view to identifying also their potential risks. It does so by making use of several different approaches, including a short review of nominal convergence and a more extensive discussion from an optimum currency area perspective. An important part of the analysis is devoted to the implications of real convergence – i.e. catching-up growth in income and adjustment of the real economic structures towards those prevailing in the euro area – on the patterns of economic dynamics in acceding countries. Other aspects covered are the risks for external competitiveness in the convergence process and the appropriate pace of fiscal consolidation.
    Keywords: ddc:330 ; Europäisches Währungssystem ; Euro ; EU-Mitgliedschaft ; Osteuropa ; Malta ; Zypern
    Repository Name: EconStor: OA server of the German National Library of Economics - Leibniz Information Centre for Economics
    Language: English
    Type: doc-type:report
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  • 6
    Publication Date: 2019-08-12
    Description: Mantle convection is a fundamental planetary process. Its plate mode is established and expressed by plate tectonics. Its plume mode also is established and expressed by interregional geological patterns. We developed both an event-based stratigraphic framework to illustrate the surface effects predicted by the plume model of Griffiths et al. (1989) and Griffiths and Campbell (1990) and a methodology to analyze continent-scale geological maps based on unconformities and hiatuses. The surface expression of ascending plumes lasts for tens-of-millions-of-years and rates vary over a few million years. As the plume ascends, its surface expression narrows, but increases in amplitude, leaving distinct geological and stratigraphic patterns in the geologic record, not only above the plume-head center, but also above its margins and in distal regions a few thousands-of-kilometers from the center. To visualize these patterns, we constructed sequential geological maps, chronostratigraphic sections, and hiatus diagrams. Dome-uplift with erosion (Şengör, 2001) and the flood basalts (Duncan and Richards, 1991; Ernst and Buchan, 2001a) are diagnostic starting points for plume-stratigraphic analyses. Mechanical collapse of the dome results in narrow rifting (Burke and Dewey, 1973), drainage-network reorganization (Cox, 1989), and flood-basalt eruption. In the marginal region, patterns of vertical movement, deformation and surface response are transient and complex. At first, the plume margin is uplifted together with the central region, but then it subsides as the plume ascents farther; With plume-head flattening, the plume margin experiences renewed outward-migrating surface uplift, erosion, broad crustal faulting, and drainage reorganization. Knickpoint migration occurs first inward-directed at ½ the rate of plume ascent and later outward-directed at the rate of asthenospheric flow. Interregional-scale unconformity-bounded stratigraphic successions document the two inversions. The distal regions, which did not experience any plume-related uplift, yield complete sedimentary records of the event; Event-related time gaps (hiatuses) in the sedimentary record increase towards the center, but the event horizon is best preserved in the distal region; it may be recognized by tracing its contacts from the center outwards. We extracted system- and series-hiatuses from interregional geological maps and built hiatus maps as proxies for paleo-dynamic topography and as a basis for comparison with results from numerical models. Interregional-scale geological maps are well suited to visualize plume-related geological records of dynamic topography in continental regions. However, geological records and hiatus information at the resolution of stages will be needed at interregional scales. The plume-stratigraphic framework is event-based, interregional, but not global, with time-dependent amplitudes that are significantly larger than those of global eustatic sea-level fluctuations. Global stratigraphic syntheses require integration of plate- and plume-stratigraphic frameworks before eustatic contributions may be assessed.
    Type: Article , PeerReviewed
    Format: text
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  • 7
    Publication Date: 2016-05-18
    Description: Mesenchymal stem cells (MSCs) seeded on specific carrier materials are a promising source for the repair of traumatic cartilage injuries. The best supportive carrier material has not yet been determined. As natural components of cartilage’s extracellular matrix, hyaluronic acid and collagen are the focus of biomaterial research. In order to optimize chondrogenic support, we investigated three different scaffold compositions of a hyaluronic acid (HA)-gelatin based biomaterial. Methods: Human MSCs (hMSCs) were seeded under vacuum on composite scaffolds of three different HA-gelatin ratios and cultured in chondrogenic medium for 21 days. Cell-scaffold constructs were assessed at different time points for cell viability, gene expression patterns, production of cartilage-specific extracellular matrix (ECM) and for (immuno-)histological appearance. The intrinsic transforming growth factor beta (TGF-beta) uptake of empty scaffolds was evaluated by determination of the TGF-beta concentrations in the medium over time. Results: No significant differences were found for cell seeding densities and cell viability. hMSCs seeded on scaffolds with higher ratios of HA showed better cartilage-like differentiation in all evaluated parameters. TGF-beta uptake did not differ between empty scaffolds. Conclusion: Higher ratios of HA support the chondrogenic differentiation of hMSCs seeded on a HA-gelatin composite scaffold.
    Electronic ISSN: 1996-1944
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by MDPI Publishing
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  • 8
    Publication Date: 2018-10-16
    Description: The olfactory epithelium as a port of entry in neonatal neurolisteriosis The olfactory epithelium as a port of entry in neonatal neurolisteriosis, Published online: 15 October 2018; doi:10.1038/s41467-018-06668-2 Listeria monocytogenes causes meningitis in newborns. Here, Pägelow et al. present a mouse model of neonatal cerebral listeriosis, and show that nasal inoculation, but not intragastric administration, leads to early brain infection in the absence of bacteraemia during the neonatal period.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 9
    Publication Date: 2016-03-03
    Description: Transparency: issues are not that simple Nature 531, 7592 (2016). doi:10.1038/531035d Authors: Warren Pearce, Sarah Hartley & Brigitte Nerlich We find Stephan Lewandowsky and Dorothy Bishop's framing of science governance to be overly simplistic and in need of a firmer evidence base ('Don't let transparency damage science'Nature529, 459–461;10.1038/529459a2016).The authors' analysis is biased by
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 10
    Publication Date: 2016-04-08
    Description: A combination of mesenchymal stem cells (MSCs) and scaffolds seems to be a promising approach for meniscus repair. To facilitate the search for an appropriate scaffold material a reliable and objective in vitro testing system is essential. This paper introduces a new scoring for this purpose and analyzes a hyaluronic acid (HA) gelatin composite scaffold and a polyurethane scaffold in combination with MSCs for tissue engineering of meniscus. The pore quality and interconnectivity of pores of a HA gelatin composite scaffold and a polyurethane scaffold were analyzed by surface photography and Berliner-Blau-BSA-solution vacuum filling. Further the two scaffold materials were vacuum-filled with human MSCs and analyzed by histology and immunohistochemistry after 21 days in chondrogenic media to determine cell distribution and cell survival as well as proteoglycan production, collagen type I and II content. The polyurethane scaffold showed better results than the hyaluronic acid gelatin composite scaffold, with signs of central necrosis in the HA gelatin composite scaffolds. The polyurethane scaffold showed good porosity, excellent pore interconnectivity, good cell distribution and cell survival, as well as an extensive content of proteoglycans and collagen type II. The polyurethane scaffold seems to be a promising biomaterial for a mesenchymal stem cell-based tissue engineering approach for meniscal repair. The new score could be applied as a new standard for in vitro scaffold testing.
    Electronic ISSN: 1996-1944
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by MDPI Publishing
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