Publikationsdatum:
2016-07-31
Beschreibung:
Using various chromatographic methods, three new megastigmane glycosides, docynicasides A-C ( 1 – 3 ) and ten known, (6 S ,9 R )-vomifoliol 9- O - β -D-xylopyranosyl-(1″ 6′)- O - β -D-glucopyranoside ( 4 ), hyperin ( 5 ), quercitrin ( 6 ), quercetin 3- α -L-arabinofuranoside ( 7 ), naringenin 7- O - β -D-glucopyranoside ( 8 ), phloridzin ( 9 ), phloretin 2′- O - β -D-xylopyranosyl-(1 6)- β -D-glucopyranoside ( 10 ), pinosylvin 3- O - β -D-glucopyranoside ( 11 ), tormentic acid ( 12 ), and chlorogenic acid methyl ester ( 13 ) were isolated from the fruits of Docynia indica . Their chemical structures were elucidated by physical and chemical methods. All the isolated compounds were evaluated for the inhibitory activity on nitric oxide production in LPS-stimulated BV2 cells. As the results, compounds 3 – 5 showed significant inhibitory activity on LPS-stimulated NO production in BV2 cells with the IC 50 values ranging from 21.0 to 29.3 μM. This article is protected by copyright. All rights reserved.
Print ISSN:
0018-019X
Digitale ISSN:
1522-2675
Thema:
Chemie und Pharmazie
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