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  • 2015-2019  (71)
  • 1930-1934
  • 2015  (71)
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  • 2015-2019  (71)
  • 1930-1934
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  • 1
    Keywords: climate change ; agriculture
    Description / Table of Contents: The Agricultural Model Intercomparison and Improvement Project: Phase I Activities by a Global Community of Science (Cynthia Rosenzweig, James W Jones, Jerry L Hatfield, John M Antle, Alexander C Ruane, and Carolyn Z Mutter) --- AgMIP's Transdisciplinary Agricultural Systems Approach to Regional Integrated Assessment of Climate Impacts, Vulnerability, and Adaptation (John M Antle, Roberto O Valdivia, Kenneth J Boote, Sander Janssen, James W Jones, Cheryl H Porter, Cynthia Rosenzweig, Alexander C Ruane, and Peter J Thorburn) --- AgMIP Climate Data and Scenarios for Integrated Assessment (Alexander C Ruane, Jonathan M Winter, Sonali P McDermid, and Nicholas I Hudson) --- Cropping Systems Modeling in AgMIP: A New Protocol-Driven Approach for Regional Integrated Assessments (Peter J Thorburn, Kenneth J Boote, John N G Hargreaves, Perry L Poulton, and James W Jones) --- Representative Agricultural Pathways and Scenarios for Regional Integrated Assessment of Climate Change Impacts, Vulnerability, and Adaptation (Roberto O Valdivia, John M Antle, Cynthia Rosenzweig, Alexander C Ruane, Joost Vervoort, Muhammad Ashfaq, Ibrahima Hathie, Sabine Homann-Kee Tui, Richard Mulwa, Charles Nhemachena, Paramasivam Ponnusamy, Herath Rasnayaka, and Harbir Singh) --- Data Interoperability Tools for Regional Integrated Assessments (Cheryl H Porter, Chris Villalobos, Dean Holzworth, Roger Nelson, Jefffrey W White, Ioannis N Athanasiadis, Meng Zhang, Sander Janssen, Rob Knapen, James W Jones, Kenneth J Boote, John Hargreaves, and John M Antle) --- The AgMIP GRIDded Crop Modeling Initiative (AgGRID) and the Global Gridded Crop Model Intercomparison (GGCMI) (Joshua Elliott and Christoph Müller) --- The AgMIP Coordinated Climate-Crop Modeling Project (C3MP): Methods and Protocols (Sonali P McDermid, Alexander C Ruane, Cynthia Rosenzweig, Nicholas I Hudson, Monica D Morales, Prabodha Agalawatte, Shakeel Ahmad, L R Ahuja, Istiqlal Amien, Saseendran S Anapalli, Jakarat Anothai, Senthold Asseng, Jody Biggs, Federico Bert, Patrick Bertuzzi, Virender S Bhatia, Marco Bindi, Ian Broad, Davide Cammarano, Ramiro Carretero, Ashfaq Ahmad Chattha, Uran Chung, Stephanie Debats, Paola Deligios, Giacomo De Sanctis, Thanda Dhliwayo, Benjamin Dumont, Lyndon Estes, Frank Ewert, Roberto Ferrise, Thomas Gaiser, Guillermo Garcia, Sika Gbegbelegbe, Vellingiri Geethalakshmi, Edward Gerardeaux, Richard Goldberg, Brian Grant, Edgardo Guevara, Jonathan Hickman, Holger Hoffmann, Huanping Huang, Jamshad Hussain, Flavio Barbosa Justino, Asha S Karunaratne, Ann-Kristin Koehler, Patrice K Kouakou, Soora Naresh Kumar, Arunachalam Lakshmanan, Mark Lieffering, Xiaomao Lin, Qunying Luo, Graciela Magrin, Marco Mancini, Fabio Ricardo Marin, Anna Dalla Marta, Yuji Masutomi, Theodoros Mavromatis, Greg McLean, Santiago Meira, Monoranjan Mohanty, Marco Moriondo, Wajid Nasim, Lamyaa Negm, Francesca Orlando, Simone Orlandini, Isik Ozturk, Helena Maria Soares Pinto, Guillermo Podesta, Zhiming Qi, Johanna Ramarohetra, Muhammad Habib ur Rahman, Helene Raynal, Gabriel Rodriguez, Reimund Rötter, Vaishali Sharda, Lu Shuo, Ward Smith, Val Snow, Afshin Soltani, K Srinivas, Benjamin Sultan, Dillip Kumar Swain, Fulu Tao, Kindie Tesfaye, Maria I Travasso, Giacomo Trombi, Alex Topaj, Eline Vanuytrecht, Federico E Viscarra, Syed Aftab Wajid, Enli Wang, Hong Wang, Jing Wang, Erandika Wijekoon, Lee Byun-Woo, Yang Xiaoguang, Ban Ho Young, Jin I Yun, Zhigan Zhao, and Lareef Zubair) --- Uncertainty in Agricultural Impact Assessment (Daniel Wallach, Linda O Mearns, Michael Rivington, John M Antle, and Alexander C Ruane) --- Uncertainties in Scaling-Up Crop Models for Large-Area Climate Change Impact Assessments (Frank Ewert, Lenny G J van Bussel, Gang Zhao, Holger Hoffmann, Thomas Gaiser, Xenia Specka, Claas Nendel, Kurt-Christian Kersebaum, Carmen Sosa, Elisabet Lewan, Jagadeesh Yeluripati, Matthias Kuhnert, Fulu Tao, Reimund Rötter, Julie Constantin, Helene Raynal, Daniel Wallach, Edmar Teixeira, Balasz Grosz, Michaela Bach, Luca Doro, Pier Paolo Roggero, Zhigan Zhao, Enli Wang, Ralf Kiese, Edwin Haas, Henrik Eckersten, Giacomo Trombi, Marco Bindi, Christian Klein, Christian Biernath, Florian Heinlein, Eckart Priesack, Davide Cammarano, Senthold Asseng, Joshua Elliott, Michael Glotter, Bruno Basso, Guillermo A Baigorria, Consuelo C Romero, and Marco Moriondo) --- Statistical Analysis of Large Simulated Yield Datasets for Studying Climate Change Effects (David Makowski, Senthold Asseng, Frank Ewert, Simona Bassu, Jean-Louis Durand, Pierre Martre, Myriam Adam, Pramod K Aggarwal, Carlos Angulo, Christian Baron, Bruno Basso, Patrick Bertuzzi, Christian Biernath, Hendrik Boogaard, Kenneth J Boote, Nadine Brisson, Davide Cammarano, Andrew J Challinor, Sjakk J G Conijn, Marc Corbeels, Delphine Deryng, Giacomo De Sanctis, Jordi Doltra, Sebastian Gayler, Richard Goldberg, Patricio Grassini, Jerry L Hatfield, Lee Heng, Steven Hoek, Josh Hooker, Tony L A Hunt, Joachim Ingwersen, Cesar Izaurralde, Raymond E E Jongschaap, James W Jones, Armen R Kemanian, Christian Kersebaum, Soo-Hyung Kim, Jon Lizaso, Christoph Müller, Naresh S Kumar, Claas Nendel, Garry J O'Leary, Jorgen E Olesen, Tom M Osborne, Taru Palosuo, Maria V Pravia, Eckart Priesack, Dominique Ripoche, Cynthia Rosenzweig, Alexander C Ruane, Fredirico Sau, Mickhail A Semenov, Iurii Shcherbak, Pasquale Steduto, Claudio Stöckle, Pierre Stratonovitch, Thilo Streck, Iwan Supit, Fulu Tao, Edmar I Teixeira, Peter Thorburn, Denis Timlin, Maria Travasso, Reimund Rötter, Katharina Waha, Daniel Wallach, Jeffrey W White, Jimmy R Williams, and Joost Wolf) --- Crop Diseases and Climate Change in the AgMIP Framework (Ariena H C van Bruggen, James W Jones, Jose Mauricio C Fernandes, Karen Garrett, and Kenneth J Boote) --- Perspectives on Climate Effects on Agriculture: The International Efforts of AgMIP in Sub-Saharan Africa (Job Kihara, Dilys S MacCarthy, Andre Bationo, Saidou Koala, Jonathan Hickman, Jawoo Koo, Charles Vanya, Samuel Adiku, Yacob Beletse, Patricia Masikate, Karuturi P C Rao, Carolyn Z Mutter, Cynthia Rosenzweig, and James W Jones) --- Climate Change Impacts on West African Agriculture: An Integrated Regional Assessment (CIWARA) (Samuel G K Adiku, Dilys S MacCarthy, Ibrahima Hathie, Madina Diancoumba, Bright S Freduah, Joseph Amikuzuno, P C Sibiry Traore, Seydou Traore, Eric Koomson, Alhassane Agali, Jon I Lizaso, Dougbedji Fatondji, Myriam Adams, Lodoun Tigana, Daouda Z Diarra, Ousmane N'diaye, and Roberto O Valdivia) --- Impacts of Climate Variability and Change on Agricultural Systems in East Africa (Karuturi P C Rao, Gummadi Sridhar, Richard M Mulwa, Mary N Kilavi, Anthony Esilaba, Ioannis N Athanasiadis, and Roberto O Valdivia) --- Projected Impacts of Climate Change Scenarios on the Production of Maize in Southern Africa: An Integrated Assessment Case Study of the Bethlehem District, Central Free State, South Africa (Yacob G Beletse, Wiltrud Durand, Charles Nhemachena, Olivier Crespo, Weldemichael A Tesfuhuney, Matthew R Jones, Mogos Y Teweldemedhin, Sunshine M Gamedze, Pontsho M Bonolo, Syanda Jonas, SueWalker, Patrick Gwimbi, Thembeka N Mpuisang, Davide Cammarano, and Roberto O Valdivia) --- Crop-Livestock Intensification in the Face of Climate Change: Exploring Opportunities to Reduce Risk and Increase Resilience in Southern Africa by Using an Integrated Multi-modeling Approach (Patricia Masikati, Sabine Homann-Kee Tui, Katrien Descheemaeker, Olivier Crespo, Sue Walker, Christopher J Lennard, Lieven Claessens, Arthur C Gama, Sebastiao Famba, Andre F van Rooyen, and Roberto O Valdivia) --- Integrated Assessments of the Impacts of Climate Change on Agriculture: An Overview of AgMIP Regional Research in South Asia (Sonali P McDermid, Guntuku Dileepkumar, K M Dakshina Murthy, S Nedumaran, Piara Singh, Chukka Srinivasa, B Gangwar, N Subash, Ashfaq Ahmad, Lareef Zubair, and S P Nissanka) --- Impact of Climate Change on the Rice–Wheat Cropping System of Pakistan (Ashfaq Ahmad, Muhammad Ashfaq, Ghulam Rasul, Syed Aftab Wajid, Tasneem Khaliq, Fahd Rasul, Umer Saeed, Muhammad Habib ur Rahman, Jamshad Hussain, Irfan Ahmad Baig, Syed Asif Ali Naqvi, Syed Ahsan Ali Bokhari, Shakeel Ahmad, Wajid Naseem, Gerrit Hoogenboom, and Roberto O Valdivia) --- Integrated Climate Change Assessment through Linking Crop Simulation with Economic Modeling — Results from the Indo-Gangetic Basin (Nataraja Subash, Babooji Gangwar, Harbir Singh, Guillermo Baigorria, Alok Kumar Sikka, and Roberto O Valdivia) --- Integrated Assessment of Climate Change Impacts on Maize Farms and Farm Household Incomes in South India: A Case Study from Tamil Nadu (Paramasivam Ponnusamy, Geethalakshmi Vellingiri, Raji Reddy Danda, Lakshmanan Arunachalam, Dakshina Murthy, Sunandini Prema, Sreenivas Gade, Sonali P McDermid, and Roberto O Valdivia) --- Climate Change Impacts on Rice Farming Systems in Northwestern Sri Lanka (Lareef Zubair, Sarath P Nissanka, W M W Weerakoon, Dumindu I Herath, Asha S Karunaratne, A S M Prabodha, M B Agalawatte, Rasnayaka M Herath, S Zeenas Yahiya, B V R Punyawardene, Janan Vishwanathan, Punya Delpitiya, A Erandika N Wijekoon, Janaka Gunaratna, Sewwandhi S K Chandrasekara, P Wickramagamage, K D N Weerasinghe, Champa M Navaratne, Ruchika S Perera, Asela I Gunesekara, G M Pradeep Kumara, Daniel Wallach, Roberto O Valdivia, and Sonali P McDermid) --- AgMIP Regional Activities in a Global Framework: The Brazil Experience (Eduardo D Assad, Fábio R Marin, Roberto O Valdivia, and Cynthia Rosenzweig) --- AgMIP Regional Activities in a Global Framework: The China Experience (Fulu Tao and Erda Lin) --- AgMIP Training in Multiple Crop Models and Tools (Kenneth J Boote, Cheryl H Porter, John Hargreaves, Gerrit Hoogenboom, Peter Thorburn, and Carolyn Mutter) --- Major Findings and Future Activities (Cynthia Rosenzweig and Daniel Hillel)
    Pages: Online-Ressource (XXVII, 525 pages (part 1); XXIII, 580 pages (part 2))
    ISBN: 9781783265633
    Language: English
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  • 2
    Publication Date: 2015-05-03
    Description: Using Monte Carlo simulation, we analyse the behaviour of two-dimensional hard rods in four different types of geometric confinement: (i) a slit pore where the particles are confined between two parallel walls with homeotropic anchoring; (ii) a hybrid slit pore formed by a planar and a homeotropic wall; square cavities that frustrate the orientational order by imposing either (iii) homeotropic or (iv) planar wall anchoring. We present results for the state diagram as a function of the packing fraction and the degree of confinement. Under extreme confinement, unexpected states appear with lower symmetries than those of the corresponding stable states in bulk, such as the formation of states that break the anchoring constraints or the symmetry imposed by the surfaces. In both types of square cavities, the particles form disclinations at intermediate densities. At high densities, however, the elastic stress is relaxed via the formation of domain walls where the director rotates abruptly by 90°.
    Print ISSN: 0021-9606
    Electronic ISSN: 1089-7690
    Topics: Chemistry and Pharmacology , Physics
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  • 3
    Publication Date: 2015-12-25
    Print ISSN: 0002-8282
    Electronic ISSN: 1944-7981
    Topics: Economics
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  • 4
    Publication Date: 2015-11-30
    Description: ClpB/Hsp100 is an ATP-dependent disaggregase that solubilizes and reactivates protein aggregates in cooperation with the DnaK/Hsp70 chaperone system. The ClpB–substrate interaction is mediated by conserved tyrosine residues located in flexible loops in nucleotide-binding domain-1 that extend into the ClpB central pore. In addition to the tyrosines, the ClpB N-terminal domain (NTD) was suggested to provide a second substrate-binding site; however, the manner in which the NTD recognizes and binds substrate proteins has remained elusive. Herein, we present an NMR spectroscopy study to structurally characterize the NTD–substrate interaction. We show that the NTD includes a substrate-binding groove that specifically recognizes exposed hydrophobic stretches in unfolded or aggregated client proteins. Using an optimized segmental labeling technique in combination with methyl-transverse relaxation optimized spectroscopy (TROSY) NMR, the interaction of client proteins with both the NTD and the pore-loop tyrosines in the 580-kDa ClpB hexamer has been characterized. Unlike contacts with the tyrosines, the NTD–substrate interaction is independent of the ClpB nucleotide state and protein conformational changes that result from ATP hydrolysis. The NTD interaction destabilizes client proteins, priming them for subsequent unfolding and translocation. Mutations in the NTD substrate-binding groove are shown to have a dramatic effect on protein translocation through the ClpB central pore, suggesting that, before their interaction with substrates, the NTDs block the translocation channel. Together, our findings provide both a detailed characterization of the NTD–substrate complex and insight into the functional regulatory role of the ClpB NTD in protein disaggregation.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 5
    Publication Date: 2015-08-03
    Description: The 70 kDa heat shock protein (Hsp70) chaperone system is ubiquitous, highly conserved, and involved in a myriad of diverse cellular processes. Its function relies on nucleotide-dependent interactions with client proteins, yet the structural features of folding-competent substrates in their Hsp70-bound state remain poorly understood. Here we use NMR spectroscopy to study the human telomere repeat binding factor 1 (hTRF1) in complex with Escherichia coli Hsp70 (DnaK). In the complex, hTRF1 is globally unfolded with up to 40% helical secondary structure in regions distal to the binding site. Very similar conformational ensembles are observed for hTRF1 bound to ATP-, ADP- and nucleotide-free DnaK. The patterns in substrate helicity mirror those found in the unfolded state in the absence of denaturants except near the site of chaperone binding, demonstrating that DnaK-bound hTRF1 retains its intrinsic structural preferences. To our knowledge, our study presents the first atomic resolution structural characterization of a client protein bound to each of the three nucleotide states of DnaK and establishes that the large structural changes in DnaK and the associated energy that accompanies ATP binding and hydrolysis do not affect the overall conformation of the bound substrate protein.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 6
    Publication Date: 2015-06-18
    Description: Author(s): Y. Sakai, I. Pogorelsky, O. Williams, F. O’Shea, S. Barber, I. Gadjev, J. Duris, P. Musumeci, M. Fedurin, A. Korostyshevsky, B. Malone, C. Swinson, G. Stenby, K. Kusche, M. Babzien, M. Montemagno, P. Jacob, Z. Zhong, M. Polyanskiy, V. Yakimenko, and J. Rosenzweig Inverse Compton scattering of laser photons by ultrarelativistic electron beam provides polarized x- to γ -ray pulses due to the Doppler blueshifting. Nonlinear electrodynamics in the relativistically intense linearly polarized laser field changes the radiation kinetics established during the Compton... [Phys. Rev. ST Accel. Beams 18, 060702] Published Wed Jun 17, 2015
    Keywords: Synchrotron Radiation and Free-Electron Lasers
    Electronic ISSN: 1098-4402
    Topics: Physics
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  • 7
    Publication Date: 2015-12-16
    Description: ClpB/Hsp100 is an ATP-dependent disaggregase that solubilizes and reactivates protein aggregates in cooperation with the DnaK/Hsp70 chaperone system. The ClpB–substrate interaction is mediated by conserved tyrosine residues located in flexible loops in nucleotide-binding domain-1 that extend into the ClpB central pore. In addition to the tyrosines, the ClpB N-terminal domain...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 8
    Publication Date: 2015-02-18
    Description: Author(s): Jere Harrison, Yongha Hwang, Omeed Paydar, Jimmy Wu, Evan Threlkeld, James Rosenzweig, Pietro Musumeci, and Rob Candler Fabrication and beam tests of miniature quadrupole electromagnets with sub-mm gap indicate path to multi-kT/m gradients. [Phys. Rev. ST Accel. Beams 18, 023501] Published Tue Feb 17, 2015
    Keywords: Other Accelerator Subsystems and Technologies
    Electronic ISSN: 1098-4402
    Topics: Physics
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  • 9
    Publication Date: 2015-01-24
    Description: Journal of Medicinal Chemistry DOI: 10.1021/jm5015742
    Topics: Chemistry and Pharmacology
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  • 10
    Publication Date: 2015-02-12
    Description: In a multicenter randomized double-blind study we demonstrated that Qiliqiangxin (QLQX), a traditional Chinese medicine, had a protective effect in heart failure patients. However, whether and via which mechanism QLQX attenuates cardiac remodeling after acute myocardial infarction (AMI) is still unclear. AMI was created by ligating the left anterior descending coronary artery in mice. Treating the mice in the initial 3 days after AMI with QLQX did not change infarct size. However, QLQX treatment ameliorated adverse cardiac remodeling 3 weeks after AMI including better preservation of cardiac function, decreased apoptosis and reduced fibrosis. Peroxisome proliferator-activated receptor-γ (PPARγ) was down-regulated in control animals after AMI and up-regulated by QLQX administration. Interestingly, expression of AKT, SAPK/JNK, and ERK was not altered by QLQX treatment. Inhibition of PPARγ reduced the beneficial effects of QLQX in AMI remodeling, whereas activation of PPARγ failed to provide additional improvement in the presence of QLQX, suggesting a key role for PPARγ in the effects of QLQX during cardiac remodeling after AMI. This study indicates that QLQX attenuates cardiac remodeling after AMI by increasing PPARγ levels. Taken together, QLQX warrants further investigation as as a therapeutic intervention to mitigate remodeling and heart failure after AMI. Scientific Reports 5 doi: 10.1038/srep08374
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Springer Nature
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