Publication Date:
2001-04-09
Description:
The Drosophila melanogaster gene insulin-like receptor (InR) is homologous to mammalian insulin receptors as well as to Caenorhabditis elegans daf-2, a signal transducer regulating worm dauer formation and adult longevity. We describe a heteroallelic, hypomorphic genotype of mutant InR, which yields dwarf females with up to an 85% extension of adult longevity and dwarf males with reduced late age-specific mortality. Treatment of the long-lived InR dwarfs with a juvenile hormone analog restores life expectancy toward that of wild-type controls. We conclude that juvenile hormone deficiency, which results from InR signal pathway mutation, is sufficient to extend life-span, and that in flies, insulin-like ligands nonautonomously mediate aging through retardation of growth or activation of specific endocrine tissue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tatar, M -- Kopelman, A -- Epstein, D -- Tu, M P -- Yin, C M -- Garofalo, R S -- R01 AG16632/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2001 Apr 6;292(5514):107-10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Brown University, Providence, RI 02912, USA., University of Massachusetts, Amherst, MA 01003, USA. Marc_Tatar@Brown.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11292875" target="_blank"〉PubMed〈/a〉
Keywords:
Aging/*physiology
;
Alleles
;
Animals
;
Carrier Proteins/*genetics/*physiology
;
Corpora Allata/*metabolism
;
*Drosophila Proteins
;
Drosophila melanogaster/genetics/*physiology
;
Female
;
Fertility
;
Genes, Insect
;
Genotype
;
Insulin/pharmacology
;
Juvenile Hormones/metabolism
;
Longevity/*physiology
;
Male
;
Methoprene/pharmacology
;
Mutation
;
Protein-Tyrosine Kinases/*genetics/*physiology
;
*Receptor Protein-Tyrosine Kinases
;
Receptor, Insulin/genetics/physiology
;
Reproduction
;
Signal Transduction
;
Superoxide Dismutase/metabolism
;
Triglycerides/metabolism
;
Vitellogenesis/drug effects
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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