Publication Date:
1991-03-22
Description:
The achaete (ac) and scute (sc) genes of Drosophila allow cells to become sensory organ mother cells. Although ac and sc have similar patterns of expression, deletion of either gene removes specific subsets of sensory organs. This specificity was shown to reside in the peculiar regulation of ac and sc expression. These genes are first activated in complementary spatial domains in response to different cis-regulatory sequences. Each gene product then stimulates expression of the other gene, thus generating similar patterns of expression. Therefore, removal of one gene leads to the absence of both proneural gene products and sensory organs in the sites specified by its cis-regulatory sequences.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Martinez, C -- Modolell, J -- New York, N.Y. -- Science. 1991 Mar 22;251(5000):1485-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centro de Biologia Molecular, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Spain.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1900954" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Drosophila melanogaster/embryology/*genetics
;
Gene Expression Regulation
;
Nervous System/*embryology
;
Promoter Regions, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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