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Digitale Medien

Alterations in the fraction of oxygen in inspired gas affect rates of renal prostaglandin E2 synthesis in anesthetized dogs (1981)

Lonigro, A. J. ; Stephenson, A. H. ; Heitmann, L. J. ; [weitere]

Springer

Cellular and molecular life sciences 37 (1981), S. 1293-1294

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ISSN: 1420-9071

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Summary Reductions of oxygen in inspired gas from 20% to 15%, in anesthetized dogs, reduced arterial PO2 and increased the renal efflux of PGE2 but not PGF2a . Renal blood flow, blood pressure, plasma renin activity as well as arterial pH and PCO2 were unaffected. PGs may mediate the renal hemodynamic or excretory consequences of alterations in PO2. In addition, minor variations in PO2 might account, in part, for the variable renal venous PGE2 concentrations reported under basal conditions.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01948368

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Digitale Medien

Elevated concentrations of mercury in mussels (Mytilus californianus) associated with pinniped colonies (1981)

Flegal, A. R. ; Stephenson, M. ; Martin, M. ; [weitere]

Springer

Marine biology 65 (1981), S. 45-48

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ISSN: 1432-1793

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie

Notizen: Abstract The geographic distribution of mercury concentrations in the California mussel Mytilus californianus, collected from 1977–1978 at 43 sites along the western coastline of the continental United States is marked by consistently elevated levels at two locations. These two sites, which are relatively isolated from anthropogenic inputs and mercuryrich minerals, both contain large pinniped and marine bird populations. The relatively elevated mercury levels measured in the excrement of a pinniped from one of those locales indicate that the concentrated discharge of mercuryrich waste products from the marine ecosystem's top carnivores is contaminating lower trophic levels.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00397066

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Digitale Medien

Histone genes are located at the sphere loci of newt lampbrush chromosomes (1981)

Gall, Joseph G. ; Stephenson, Edwin C. ; Erba, Harry P. ; [weitere]

Springer

Chromosoma 84 (1981), S. 159-171

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ISSN: 1432-0886

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Abstract In situ hybridization experiments on mitotic and lampbrush chromosomes show that histone genes and an associated 222 bp repeated sequence, satellite 1, are located at or near the sphere loci of chromosomes 2 and 6 of the newt Notophthalmus viridescens. During the lampbrush chromosome stage, transcripts of the histone genes and of satellite 1 occur on loops associated with the spheres. Histone genes are located at sites on the mitotic chromosomes of Triturus cristatus and T. alpestris which are consistent with the known positions of spheres on their lampbrush chromosomes.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00399128

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4

Digitale Medien

Models of coupled salt and water transport across leaky epithelia (1981)

Weinstein, Alan M. ; Stephenson, John L.

Springer

The journal of membrane biology 60 (1981), S. 1-20

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ISSN: 1432-1424

Schlagwort(e): isotonic epithelial transport ; lateral intercellular space ; linearized Kedem-Katchalsky equations ; intraepithelial solute polarization

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Chemie und Pharmazie

Notizen: Summary A general formulation is presented for the verification of isotonic transport and for the assignment of a degree of osmotic coupling in any epithelial model. In particular, it is shown that the concentration of the transported fluid in the presence of exactly equal bathing media is, in general, not a sufficient calculation by which to decide the issue of isotonicity of transport. Within this framework, two epithelial models are considered: (1) A nonelectrolyte compartment model of the lateral intercellular space is presented along with its linearization about the condition of zero flux. This latter approximate model is shown to be useful in the estimation of deviation from isotonicity, intraepithelial solute polarization effects, and the capacity to transport water against a gradient. In the case of uphill water transport, some limitations of a model of fixed geometry are indicated and the advantage of modeling a compliant interspace is suggested. (2) A comprehensive model of cell and channel is described which includes the major electrolytes and the possible presence of intraepithelial gradients. The general approach to verification of isotonicity is illustrated for this numerical model. In addition, the insights about parameter dependence gained from the linear compartment model are shown to be applicable to understanding this large simulation.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01870828

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