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  • Animals  (78)
  • SOLAR PHYSICS  (45)
  • 1980-1984
  • 1975-1979  (123)
  • 1979  (123)
  • 1
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    Digitalis genin activity: side-group carbonyl oxygen position is a major determinant (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1979-08-31
    Beschreibung: The Na+,k+-adenosine triphosphatase-inhibiting activity of digitalis genins and their analogs is a function of side-group carbonyl (C = O) oxygen position. For each 2.2 angstroms that this oxygen is displaced from its position in digitoxigenin, activity drops by one order of magnitude. This quantitative relation resolves previously proposed models which have attempted to describe the molecular basis of genin activity. A multidisciplinary (crystallographic, conformational energy, synthetic, biological) approach to structure-activity relations is described.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fullerton, D S -- Yoshioka, K -- Rohrer, D C -- From, A H -- Ahmed, K -- New York, N.Y. -- Science. 1979 Aug 31;205(4409):917-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/224455" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Brain/enzymology ; Digitalis Glycosides/*pharmacology ; Molecular Conformation ; Rats ; Sodium-Potassium-Exchanging ATPase/*antagonists & inhibitors ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
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    Iron deficiency prevents liver toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1979-04-20
    Beschreibung: The compound 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes hepatocellular damage and porphyria in C57B1/6J mice, among a wide range of toxic effects. We compared the effect of TCDD toxicity in iron-deficient mice with that in mice receiving a normal diet. Porphyria did not develop in the iron-deficient animals, and these animals were also protected from hepatocellular damage and certain other toxic effects of TCDD.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sweeny, G D -- Jones, K G -- Cole, F M -- Basford, D -- Krestynski, F -- New York, N.Y. -- Science. 1979 Apr 20;204(4390):332-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432648" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Dioxins/*toxicity ; Enzyme Induction ; Iron/*deficiency ; Liver/pathology ; Mice ; Microsomes, Liver/enzymology ; Mixed Function Oxygenases/metabolism ; Porphyrias/*chemically induced ; Tetrachlorodibenzodioxin/*toxicity ; Uroporphyrinogen Decarboxylase/metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
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    Thalamic and cortical afferents differentiate anterior from posterior cingulate cortex in the monkey (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1979-04-13
    Beschreibung: The anterior cingulate cortex receives thalamic afferents mainly from the midline and intralaminar nuclei rather than the anterior thalamic nuclei. In contrast, the posterior cingulate cortex receives afferents primarily from the anterior thalamic nuclei and from extensive cortical areas in the frontal, parietal, and temporal lobes. These contrasting afferents may provide a structural basis for pain-related functions of the anterior cingulate cortex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogt, B A -- Rosene, D L -- Pandya, D N -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):205-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/107587" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Afferent Pathways/cytology ; Animals ; Brain Mapping ; Cerebral Cortex/*cytology ; Gyrus Cinguli/*cytology/physiology ; Haplorhini ; Horseradish Peroxidase ; Macaca mulatta ; Thalamic Nuclei/*cytology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
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    Species-specific perceptual processing of vocal sounds by monkeys (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1979-05-25
    Beschreibung: Monkeys of four species were trained to discriminate between sets of natural tonal calls of Japanese macaques (Macaca fuscata) by the position of a frequency-inflection peak or by initial pitch. The Japanese macaques consistently performed best on peak position and the other species on pitch. The results imply special strategies for perceptional processing of vocal sounds and suggest parallels with human speech perception.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zoloth, S R -- Petersen, M R -- Beecher, M D -- Green, S -- Marler, P -- Moody, D B -- Stebbins, W -- New York, N.Y. -- Science. 1979 May 25;204(4395):870-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/108805" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Auditory Perception/*physiology ; Haplorhini ; Macaca/*physiology ; Species Specificity ; Speech Perception/*physiology ; Vocalization, Animal/*physiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
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    Target velocity signals of visual tracking in vermal Purkinje cells of the monkey (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1979-08-17
    Beschreibung: Discharges of Purkinje cells were recorded from the vermis, lobules VI and VII, of a monkey trained to track a visual target. When the monkey tracked a sinusoidally oscillating target, cellular activity changes in phase with the velocity signal of the eye movement. When the monkey fixated a stationary point, almost identical modulation in activity occurred, reflecting the velocity signal of the motion of the retinal image of the target. The data suggest that the vermis participates in the control of smooth pursuit eye movements by providing the oculomotor system with the actual target velocity information which is the sum of eye velocity and retinal image velocity signals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kase, M -- Noda, H -- Suzuki, D A -- Miller, D C -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):717-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/111350" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Action Potentials ; Animals ; *Eye Movements ; Haplorhini ; Motion Perception/physiology ; Proprioception ; Purkinje Cells/*physiology ; Visual Perception/*physiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
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    Lens epithelial cell elongation in the absence of microtubules: evidence for a new effect of colchicine (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1979-11-16
    Beschreibung: Embryonic chick lens epithelial cells cultured in serum-supplemented medium elongated in the absence of microtubules after treatment with the antimicrotubule drug nocodazole. Colchicine, at concentrations lower than those that dissociate microtubules, blocks cell elongation and the associated increase in cell volume. These results indicate that an increase in cell volume, not microtubules, is responsible for lens cell elongation and suggest a previously undescribed effect of colchicine on cell volume regulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beebe, D C -- Feagans, D E -- Blanchette-Mackie, E J -- Nau, M E -- New York, N.Y. -- Science. 1979 Nov 16;206(4420):836-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493982" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Benzimidazoles/pharmacology ; Carbamates/pharmacology ; Cells, Cultured ; Chick Embryo ; Colchicine/*pharmacology ; Epithelium/ultrastructure ; Lens, Crystalline/*cytology ; Microtubules/*drug effects
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
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    A systematic assessment of early African hominids (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1979-01-26
    Beschreibung: A large sample of Pliocene fossil hominid remains has been recovered from the African sites of Hadar in Ethiopia and Laetolil in Tanzania. These collections, dating approximately between 2.9 and 3.8 million years ago, constitute the earliest substantial record of the family Hominidae. This article assesses the phylogenetic relationships of the newly discovered fossil hominids and provides a taxonomy consistent with that assessment. A new taxon, Australopithecus afarensis, has been created to accommodate these Pliocene hominid fossils.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Johanson, D C -- White, T D -- New York, N.Y. -- Science. 1979 Jan 26;203(4378):321-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/104384" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Africa, Eastern ; Africa, Southern ; Animals ; Biological Evolution ; Craniology ; Dental Arch ; *Fossils ; Haplorhini/*anatomy & histology/classification ; History, Ancient ; Humans ; *Paleodontology ; *Paleontology ; Phylogeny ; Primates/*anatomy & histology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 8
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    Effect of fluorine substitution on the agonist specificity of norepinephrine (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1979-06-15
    Beschreibung: Substitution of fluorine for hydrogen in position 2, 5, or 6 of the aromatic ring of norepinephrine markedly alters the alpha- and beta-adrenergic agonist properties of norephinephrine. The 6-fluoro isomer is an beta-adrenergic agonist with virtually no beta agonist activity, while the 2-fluoro isomer is a beta-adrenergic agonist with little alpha activity. The 5-fluoro isomer is equipotent with norepinephrine as an alpha agonist and significantly more potent as a beta agonist. The possible physiochemical basis for these differences is discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cantacuzene, D -- Kirk, K L -- McCulloh, D H -- Creveling, C R -- New York, N.Y. -- Science. 1979 Jun 15;204(4398):1217-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/221978" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Aorta ; Fluorine ; Guinea Pigs ; Hydrogen Bonding ; In Vitro Techniques ; Norepinephrine/*analogs & derivatives/chemical synthesis/pharmacology ; Receptors, Adrenergic/*drug effects ; Receptors, Adrenergic, alpha/*drug effects ; Receptors, Adrenergic, beta/*drug effects ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
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    Mullerian duct regression in the embryo correlated with cytotoxic activity against human ovarian cancer (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1979-08-31
    Beschreibung: A significant cytotoxicity index was obtained when human ovarian cancer cells in a microcytotoxicity assay were exposed during the S (DNA-synthesizing) phase of the cell cycle to purified fractions of testis exhibiting high Mullerian inhibiting substance bioactivity. The same effect was not observed when these fractions were tested against human glioblastoma or fibroblast lines. Most human ovarian cancers are said to resemble Mullerian tissues histologically. Mullerian inhibiting substance may thus deserve further study as a potential chemotherapeutic agent.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Donahoe, P K -- Swann, D A -- Hayashi, A -- Sullivan, M D -- New York, N.Y. -- Science. 1979 Aug 31;205(4409):913-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472712" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cattle ; Culture Techniques ; Cystadenoma/*therapy ; Cytotoxins/therapeutic use ; Female ; Humans ; Male ; Mullerian Ducts/*physiology ; Ovarian Neoplasms/*therapy ; Receptors, Drug/physiology ; Testis/embryology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
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    Radiation transfer through a model sunspot (1979)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-06-27
    Beschreibung: A cylindrically symmetric model for a sunspot atmosphere using the similarity principle of Schlueter and Temesvary for the magnetic field configuration is presented. The equations of magnetostatic equilibrium are used, augmented by a radial Evershed flow. The LTE radiative transfer equations for the Stokes vector were solved under a variety of conditions for a ray emerging from a typical penumbral point. The contribution from isolated lines to the broadband circular polarization in sunspot penumbrae is evaluated using a more realistic model sunspot atmosphere than has hitherto been considered. Results indicate that the inclusion of a velocity field along the magnetic field vector is unable to give a net circular polarization of sufficient magnitude, although the variation with the angle between the line-of-sight and the magnetic field vector is in qualitative agreement with observations. The corresponding results for the net linear polarization are satisfactory.
    Schlagwort(e): SOLAR PHYSICS
    Materialart: Solar Physics; 63; Sept
    Format: text
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