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  • Articles  (13)
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  • Royal Society Open Science  (12)
  • 220702
  • 1
    Publication Date: 2015-10-31
    Description: Bears produce the most altricial neonates of any placental mammal. We hypothesized that the transition from colostrum to mature milk in bears reflects a temporal and biochemical adaptation for altricial development and immune protection. Comparison of bear milks with milks of other eutherians yielded distinctive protein profiles. Proteomic and metabolomic analysis of serial milk samples collected from six giant pandas showed a prolonged transition from colostrum to main-phase lactation over approximately 30 days. Particularly striking are the persistence or sequential appearance of adaptive and innate immune factors. The endurance of immunoglobulin G suggests an unusual duration of trans-intestinal absorption of maternal antibodies, and is potentially relevant to the underdeveloped lymphoid system of giant panda neonates. Levels of certain milk oligosaccharides known to exert anti-microbial activities and/or that are conducive to the development of neonatal gut microbiomes underwent an almost complete changeover around days 20–30 postpartum, coincident with the maturation of the protein profile. A potential metabolic marker of starvation was detected, the prominence of which may reflect the natural postpartum period of anorexia in giant panda mothers. Early lactation in giant pandas, and possibly in other ursids, appears to be adapted for the unique requirements of unusually altricial eutherian neonates.
    Keywords: biochemistry, developmental biology, immunology
    Electronic ISSN: 2054-5703
    Topics: Natural Sciences in General
    Published by Royal Society
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  • 2
    Publication Date: 2018-10-18
    Description: In order to figure out the decomposition of muscovite and the release mechanism of vanadium from vanadium shale in the alkaline fusion process, the process of vanadium release and roasting kinetics by alkaline fusion was studied. It was found that the addition of sodium hydroxide made the muscovite convert into the sodium silicate and gehlenite. This process promoted the dissolution of silicon and the destruction of muscovite, which could facilitate the release of vanadium. The kinetic analysis indicated that the controlling step of vanadium transformation reaction is changed from chemical reaction control to diffusion control with the increase of roasting time. Compared to the diffusion controlling step, the vanadium related chemical reaction was completed in the first period. The alkaline fusion reaction enhanced the decomposition of muscovite, which could accelerate the release of vanadium and reduce the dependence on high temperature and time in the roasting process. The apparent activation energies of chemical reaction control and diffusion control were 42.24 kJ mol –1 and –9.553 kJ mol –1 , respectively. The kinetic model of vanadium extraction from vanadium shale using alkaline fusion could be finally established.
    Keywords: chemical physics, analysis
    Electronic ISSN: 2054-5703
    Topics: Natural Sciences in General
    Published by Royal Society
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  • 3
    Publication Date: 2018-09-13
    Description: One-pot solution method to grow large hexagonal ZnO microdiscs with the aid of ammonium fluoride (NH 4 F) mineralizer has been realized. The size, morphology, crystallinity and optical properties of the synthesized ZnO microdiscs can be efficiently modulated by the concentration of NH 4 F. X-ray diffraction and scanning electron microscopy analyses illustrate that hexagonal ZnO microdiscs achieved at 0.03 M NH 4 F concentration have larger disc size and narrower full-width value at half maximum of (002) peak. It implies better crystal quality compared with those from other additive concentrations. Photoluminescence results also demonstrate the same trend. These results indicate that with proper addition of NH 4 F, the crystal quality of ZnO microdiscs has been improved and defects have been suppressed. Furthermore, a UV photodetector has been fabricated by simply transferring the ZnO microdiscs grown with 0.03 M NH 4 F onto a p -type silicon substrate. The device exhibits photosensitive behaviour at 365 nm UV light illuminating when –0.6 V is applied. The response time as well as recovery time is less than 0.1 s. The relatively large photoresponsivity of 1.19 A W –1 with power consumption less than 10 nW makes it possible in application field of highly efficient low power consumption UV detection.
    Keywords: inorganic chemistry, materials science
    Electronic ISSN: 2054-5703
    Topics: Natural Sciences in General
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  • 4
    Publication Date: 2016-06-10
    Description: Images of dust continuum and carbon monoxide (CO) line emission are powerful tools for deducing structural characteristics of galaxies, such as disc sizes, H 2 gas velocity fields and enclosed H 2 and dynamical masses. We report on a fundamental constraint set by the cosmic microwave background (CMB) on the observed structural and dynamical characteristics of galaxies, as deduced from dust continuum and CO-line imaging at high redshifts. As the CMB temperature rises in the distant Universe, the ensuing thermal equilibrium between the CMB and the cold dust and H 2 gas progressively erases all spatial and spectral contrasts between their brightness distributions and the CMB. For high-redshift galaxies, this strongly biases the recoverable H 2 gas and dust mass distributions, scale lengths, gas velocity fields and dynamical mass estimates. This limitation is unique to millimetre/submillimetre wavelengths and unlike its known effect on the global dust continuum and molecular line emission of galaxies, it cannot be addressed simply. We nevertheless identify a unique signature of CMB-affected continuum brightness distributions, namely an increasing rather than diminishing contrast between such brightness distributions and the CMB when the cold dust in distant galaxies is imaged at frequencies beyond the Raleigh–Jeans limit. For the molecular gas tracers, the same effect makes the atomic carbon lines maintain a larger contrast than the CO lines against the CMB.
    Keywords: astrophysics, interstellar medium, cosmology
    Electronic ISSN: 2054-5703
    Topics: Natural Sciences in General
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  • 5
    Publication Date: 2018-11-01
    Description: Thermally induced deterioration behaviour can cause severe weathering in marbles. Most previous studies focus on the deterioration behaviour of calcitic marbles. Relevant studies of dolomitic marbles are generally carried out under a ‘high temperature and low cycling times' condition. Little attention is focused on the deterioration behaviour in dolomitic marbles when they are subjected to a large quantity of heating–cooling cycles under a ‘low temperature and high cycling times’ condition. This paper presents experimental investigations on the thermally induced deterioration behaviour of two Beijing dolomitic marbles (Qingbaishi Marble (QM) and Hanbaiyu Marble (HM)) under heating–cooling cycles up to 1000 cycling times. The applied temperature range is from –20°C to 60°C which is to simulate the seasonal temperature variations in Beijing city, China. Related properties such as weight loss, three-dimensional microtopography, elastic wave velocity and uniaxial compressive strength were measured at certain cycles. The results indicate that thermally induced deterioration behaviour will result in a continuous weight loss in dolomitic marble samples. Mechanical properties of those two marbles are strongly affected by heating and cooling treatments, which were reflected by the reductions of dynamic Young's modulus and uniaxial compressive strength with an increase of thermal cycles. Compared with QM, HM displays a higher level of thermally induced deterioration which should be due to the abundance of quartz mineral.
    Keywords: engineering geology
    Electronic ISSN: 2054-5703
    Topics: Natural Sciences in General
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  • 6
    Publication Date: 2018-09-06
    Description: Deep-UV light detection has important application in surveillance and homeland security regions. CH 3 NH 3 PbX 3 (X = Cl, Br, I) materials have outstanding optical absorption and electronic transport properties suitable for obtaining excellent deep-UV photoresponse. In this work, we have grown high-quality CH 3 NH 3 PbX 3 (X = Cl, Br, I) bulk crystals and used them to fabricate photodetectors. We found that they all have high-sensitive and fast-speed response to 255 nm deep-UV light. Their responsivities are 10–10 3 times higher than MgZnO and Ga 2 O 3 detectors, and their response speeds are 10 3 times faster than Ga 2 O 3 and ZnO detectors. These results indicate a new promising route for deep-UV detection.
    Keywords: materials science
    Electronic ISSN: 2054-5703
    Topics: Natural Sciences in General
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  • 7
    Publication Date: 2018-11-08
    Description: We report the supersonic gas flow for crush and mechanochemical synthesis. The key instrument parameters for production of supersonic particle flow, such as annular nozzle, expansion angle and length of the accelerating duct, are theoretically designed and optimized. Based on the theoretical results, supersonic gas flow equipment is fabricated. The capacity of the present equipment for production of supersonic particle flow is demonstrated by particle image velocimetry measurement, and the maximum transient velocity of the particles achieves as much as 550 m s –1 . Additionally, the present equipment is applied for continuous and physical preparation of ultrafine Si powders with a high scalability and mechanochemical synthesis of TiO 2 and TiN x nanopowders at a high production rate.
    Keywords: materials science
    Electronic ISSN: 2054-5703
    Topics: Natural Sciences in General
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  • 8
    Publication Date: 2017-07-20
    Description: Two new lactone-containing selaginellins T and U ( 1 and 2 ) together with eleven known selaginellin derivatives ( 3 and 7 – 16 ) were isolated from the whole plant of Selaginella tamariscina . The structure of tautomeric selaginellin U along with its biogenetic pathway was confirmed and proposed by a cross-validation of the semisynthesis of compound 4 from selaginellin ( 3 ) and derivation from 2 to 4 . Additionally, compounds 3 , 13 and 16 exhibited good inhibitory activities against β-site amyloid precursor protein cleaving enzyme 1 (BACE1) with IC 50 values of 81.17, 51.13 and 48.89 µM, respectively.
    Keywords: organic chemistry, synthetic chemistry
    Electronic ISSN: 2054-5703
    Topics: Natural Sciences in General
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  • 9
    Publication Date: 2016-09-16
    Description: Self-healing composites are able to restore their properties automatically. Impressive healing efficiencies can be achieved when conditions are favourable. On the other hand, healing might not be possible under adverse circumstances such as very low ambient temperature. Here, we report a structural composite able to maintain its temperature to provide a sustainable self-healing capability—similar to that in the natural world where some animals keep a constant body temperature to allow enzymes to stay active. The composite embeds three-dimensional hollow vessels with the purpose of delivering and releasing healing agents, and a porous conductive element to provide heat internally to defrost and promote healing reactions. A healing efficiency over 100% at around –60°C was obtained. The effects of the sheets on the interlaminar and tensile properties have been investigated experimentally. The proposed technique can be implemented in a majority of extrinsic self-healing composites to enable automatic recovery at ultra-low temperatures.
    Keywords: materials science, mechanical engineering
    Electronic ISSN: 2054-5703
    Topics: Natural Sciences in General
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  • 10
    Publication Date: 2017-04-27
    Description: A previous study found the key transcription factor of Litopenaeus vannamei PERK-eIF2α pathway cyclic AMP-dependent transcription factor 4 (LvATF4) was involved in the transcriptional regulation of white spot syndrome virus (WSSV) gene wsv023 . Knocked-down expression of LvATF4 reduced the viral copy number and the cumulative mortality of WSSV-infected shrimp. These results suggested that wsv023 may be critical to WSSV infection but the precise function of wsv023 was still unknown. By using co-immunoprecipitation and pull-down assays, we show that wsv023 interacts with L. vannamei gamma complex-associated protein 2 (LvGCP2), which is the core protein of the -tubulin small complex. Knocked-down, the wsv023 gene significantly reduced the copy number of WSSV in L. vannamei muscle, as well as the cumulative mortality of infected shrimp. And PERK-eIF2α pathway inhibition also showed reduced virus copy number and abrogated shrimp mortality. Furthermore, overexpression of wsv023 inhibited the formation of microtubules in 293T cells. Flow cytometry revealed that WSSV infection similarly decreased the formation of microtubules in L. vannamei haemocytes. These findings suggested that wsv023 plays a role in microtubule organization in host cells, which in turn may be beneficial to WSSV.
    Keywords: immunology, cellular biology, environmental science
    Electronic ISSN: 2054-5703
    Topics: Natural Sciences in General
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