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Identification of Novel ROS Inducers: Quinone Derivatives Tethered to Long Hydrocarbon Chains (2015)

Yeonsun Hong, Sandip Sengupta, Wooyoung Hur and Taebo Sim

American Chemical Society (ACS)

In: Journal of Medicinal Chemistry

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Publication Date: 2015-04-16

Description: Journal of Medicinal Chemistry DOI: 10.1021/jm501846y

Topics: Chemistry and Pharmacology

Published by American Chemical Society (ACS)

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Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) (2015)

Snahel Patel, Seth F. Harris, Paul Gibbons, Gauri Deshmukh, Amy Gustafson, Terry Kellar, Han Lin, Xingrong Liu, Yanzhou Liu, Yichin Liu, Changyou Ma, Kimberly Scearce-Levie, Arundhati Sengupta Ghosh, Young G. Shin, Hilda Solanoy, Jian Wang, Bei Wang, Jianping Yin, Michael Siu and Joseph W. Lewcock

American Chemical Society (ACS)

In: Journal of Medicinal Chemistry

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Publication Date: 2015-10-03

Description: Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.5b01072

Topics: Chemistry and Pharmacology

Published by American Chemical Society (ACS)

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Discovery of Dual Leucine Zipper Kinase (DLK, MAP3K12) Inhibitors with Activity in Neurodegeneration Models (2014)

Snahel Patel, Frederick Cohen, Brian J. Dean, Kelly De La Torre, Gauri Deshmukh, Anthony A. Estrada, Arundhati Sengupta Ghosh, Paul Gibbons, Amy Gustafson, Malcolm P. Huestis, Claire E. Le Pichon, Han Lin, Wendy Liu, Xingrong Liu, Yichin Liu, Cuong Q. Ly, Joseph P. Lyssikatos, Changyou Ma, Kimberly Scearce-Levie, Young G. Shin, Hilda Solanoy, Kimberly L. Stark, Jian Wang, Bei Wang, Xianrui Zhao, Joseph W. Lewcock and Michael Siu

American Chemical Society (ACS)

In: Journal of Medicinal Chemistry

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Publication Date: 2014-10-25

Description: Journal of Medicinal Chemistry DOI: 10.1021/jm5013984

Topics: Chemistry and Pharmacology

Published by American Chemical Society (ACS)

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[ASAP] Dual Leucine Zipper Kinase Inhibitors for the Treatment of Neurodegeneration Miniperspective (2018)

Michael Siu, Arundhati Sengupta Ghosh, Joseph W. Lewcock

American Chemical Society (ACS)

In: Journal of Medicinal Chemistry

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Publication Date: 2018-06-12

Description: Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.8b00370

Topics: Chemistry and Pharmacology

Published by American Chemical Society (ACS)

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Identification of the First Selective Activin Receptor-Like Kinase 1 Inhibitor, a Reversible Version of L-783277 (2017)

Hanna Cho, Sandip Sengupta, Sean S. H. Jeon, Wooyoung Hur, Hwan Geun Choi, Hong-Seog Seo, Byung Joo Lee, Jeong Hun Kim, Minhwan Chung, Noo Li Jeon, Nam Doo Kim and Taebo Sim

American Chemical Society (ACS)

In: Journal of Medicinal Chemistry

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Publication Date: 2017-02-07

Description: Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.6b01679

Topics: Chemistry and Pharmacology

Published by American Chemical Society (ACS)

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Neutral Porphyrin Derivative Exerts Anticancer Activity by Targeting Cellular Topoisomerase I (Top1) and Promotes Apoptotic Cell Death without Stabilizing Top1-DNA Cleavage Complexes (2018)

Subhendu K. Das, Arijit Ghosh, Srijita Paul Chowdhuri, Nyancy Halder, Ishita Rehman, Souvik Sengupta, Krushna Chandra Sahoo, Harapriya Rath and Benu Brata Das

American Chemical Society (ACS)

In: Journal of Medicinal Chemistry

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Publication Date: 2018-01-12

Description: Journal of Medicinal Chemistry DOI: 10.1021/acs.jmedchem.7b01297

Topics: Chemistry and Pharmacology

Published by American Chemical Society (ACS)

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