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Corrigendum: Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk (2015)

Sara Lindström; Deborah J. Thompson; Andrew D. Paterson; Jingmei Li; Gretchen L. Gierach; Christopher Scott; Jennifer Stone; Julie A. Douglas; Isabel dos-Santos-Silva; Pablo Fernandez-Navarro; Jajini Verghase; Paula Smith; Judith Brown; Robert Luben; Nicholas J. Wareham; Ruth J. F. Loos; John A. Heit; V. Shane Pankratz; Aaron Norman; Ellen L. Goode; Julie M. Cunningham; Mariza de; Andrade; Robert A. Vierkant; Kamila Czene; Peter A. Fasching; Laura Baglietto; Melissa C. Southey; Graham G. Giles; Kaanan P. Shah; Heang-Ping Chan; Mark A. Helvie; Andrew H. Beck; Nicholas W. Knoblauch; Aditi Hazra; David J. Hunter; Peter Kraft; Marina Pollan; Jonine D. Figueroa; Fergus J. Couch; John L. Hopper; Per Hall; Douglas F. Easton; Norman F. Boyd; Celine M. Vachon; Rulla M. Tamimi

Springer Nature

In: Nature Communications

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Publication Date: 2015-09-11

Description: Corrigendum Nature Communications doi: 10.1038/ncomms9358 Authors: Sara Lindström, Deborah J. Thompson, Andrew D. Paterson, Jingmei Li, Gretchen L. Gierach, Christopher Scott, Jennifer Stone, Julie A. Douglas, Isabel dos-Santos-Silva, Pablo Fernandez-Navarro, Jajini Verghase, Paula Smith, Judith Brown, Robert Luben, Nicholas J. Wareham, Ruth J. F. Loos, John A. Heit, V. Shane Pankratz, Aaron Norman, Ellen L. Goode, Julie M. Cunningham, Mariza deAndrade, Robert A. Vierkant, Kamila Czene, Peter A. Fasching, Laura Baglietto, Melissa C. Southey, Graham G. Giles, Kaanan P. Shah, Heang-Ping Chan, Mark A. Helvie, Andrew H. Beck, Nicholas W. Knoblauch, Aditi Hazra, David J. Hunter, Peter Kraft, Marina Pollan, Jonine D. Figueroa, Fergus J. Couch, John L. Hopper, Per Hall, Douglas F. Easton, Norman F. Boyd, Celine M. Vachon, Rulla M. Tamimi

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes (2016)

George Eng; Benjamin W. Lee; Lev Protas; Mark Gagliardi; Kristy Brown; Robert S. Kass; Gordon Keller; Richard B. Robinson; Gordana Vunjak-Novakovic

Springer Nature

In: Nature Communications

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Publication Date: 2016-01-21

Description: Article The use of stem cell-derived cardiomyocytes for heart repair is hampered by their immature structural and contractile properties that may cause arrhythmia. Here, Eng et al. show that electrical conditioning of human cardiomyocytes in 3D culture can enhance connectivity and provide resistance to arrhythmia. Nature Communications doi: 10.1038/ncomms10312 Authors: George Eng, Benjamin W. Lee, Lev Protas, Mark Gagliardi, Kristy Brown, Robert S. Kass, Gordon Keller, Richard B. Robinson, Gordana Vunjak-Novakovic

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk (2014)

Sara Lindström; Deborah J. Thompson; Andrew D. Paterson; Jingmei Li; Gretchen L. Gierach; Christopher Scott; Jennifer Stone; Julie A. Douglas; Isabel dos-Santos-Silva; Pablo Fernandez-Navarro; Jajini Verghase; Paula Smith; Judith Brown; Robert Luben; Nicholas J. Wareham; Ruth J. F. Loos; John A. Heit; V. Shane Pankratz; Aaron Norman; Ellen L. Goode; Julie M. Cunningham; Mariza de; Andrade; Robert A. Vierkant; Kamila Czene; Peter A. Fasching; Laura Baglietto; Melissa C. Southey; Graham G. Giles; Kaanan P. Shah; Heang-Ping Chan; Mark A. Helvie; Andrew H. Beck; Nicholas W. Knoblauch; Aditi Hazra; David J. Hunter; Peter Kraft; Marina Pollan; Jonine D. Figueroa; Fergus J. Couch; John L. Hopper; Per Hall; Douglas F. Easton; Norman F. Boyd; Celine M. Vachon; Rulla M. Tamimi

Springer Nature

In: Nature Communications

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Publication Date: 2014-10-26

Description: Article Mammographic density is a strong risk factor for breast cancer. Here, the authors identify several new loci associated dense area, non-dense area and percent density, and highlight a shared genetic basis for mammographic density and breast cancer. Nature Communications doi: 10.1038/ncomms6303 Authors: Sara Lindström, Deborah J. Thompson, Andrew D. Paterson, Jingmei Li, Gretchen L. Gierach, Christopher Scott, Jennifer Stone, Julie A. Douglas, Isabel dos-Santos-Silva, Pablo Fernandez-Navarro, Jajini Verghase, Paula Smith, Judith Brown, Robert Luben, Nicholas J. Wareham, Ruth J. F. Loos, John A. Heit, V. Shane Pankratz, Aaron Norman, Ellen L. Goode, Julie M. Cunningham, Mariza deAndrade, Robert A. Vierkant, Kamila Czene, Peter A. Fasching, Laura Baglietto, Melissa C. Southey, Graham G. Giles, Kaanan P. Shah, Heang-Ping Chan, Mark A. Helvie, Andrew H. Beck, Nicholas W. Knoblauch, Aditi Hazra, David J. Hunter, Peter Kraft, Marina Pollan, Jonine D. Figueroa, Fergus J. Couch, John L. Hopper, Per Hall, Douglas F. Easton, Norman F. Boyd, Celine M. Vachon, Rulla M. Tamimi

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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Integrating evolutionary dynamics into treatment of metastatic castrate-resistant prostate cancer (2017)

Jingsong Zhang; Jessica J. Cunningham; Joel S. Brown; Robert A. Gatenby

Springer Nature

In: Nature Communications

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Publication Date: 2017-11-28

Description: Integrating evolutionary dynamics into treatment of metastatic castrate-resistant prostate cancer Integrating evolutionary dynamics into treatment of metastatic castrate-resistant prostate cancer, Published online: 28 November 2017; doi:10.1038/s41467-017-01968-5 Evolution of resistance is a common cause of cancer treatment failure and tumor progression. Here, the authors present a method for integrating evolutionary principles based on adaptive therapy into abiraterone therapy for metastatic castrate-resistant prostate cancer and show the positive results of an interim analysis of a trial cohort.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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A transgenic approach for controlling Lygus in cotton (2016)

Gowda, Anilkumar ; Rydel, Timothy J. ; Wollacott, Andrew M. ; [et al.]

Springer Nature

In: Nature Communications. 2016; 7(1): 12213. Published 2016 Jul 18. doi: 10.1038/ncomms12213.

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Publication Date: 2016-07-18

Description: Lygus species of plant-feeding insects have emerged as economically important pests of cotton in the United States. These species are not controlled by commercial Bacillus thuringiensis (Bt) cotton varieties resulting in economic losses and increased application of insecticide. Previously, a Bt crystal protein (Cry51Aa2) was reported with insecticidal activity against Lygus spp. However, transgenic cotton plants expressing this protein did not exhibit effective protection from Lygus feeding damage. Here we employ various optimization strategies, informed in part by protein crystallography and modelling, to identify limited amino-acid substitutions in Cry51Aa2 that increase insecticidal activity towards Lygus spp. by 〉200-fold. Transgenic cotton expressing the variant protein, Cry51Aa2.834_16, reduce populations of Lygus spp. up to 30-fold in whole-plant caged field trials. One transgenic event, designated MON88702, has been selected for further development of cotton varieties that could potentially reduce or eliminate insecticide application for control of Lygus and the associated environmental impacts.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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