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  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Nervous system Surgery. ; Neurology . ; Radiology. ; Pediatrics. ; Neurosurgery. ; Neurology. ; Radiology. ; Pediatrics.
    Description / Table of Contents: I Overview -- 1 Historical landmarks in pineal region surgery -- 2 Pineal region anatomy -- 3 Pathology of Pineal Region Lesions -- 4 Clinical presentation -- 5 Imagistic diagnosis -- 6 The Usefulness of Biomarkers for Diagnosis -- 7 Surgical Adjuvants for pineal region approach -- II Surgical approaches for pineal region lesions -- 8 Supracerebellar infratentorial approach -- 9 Occipital transtentorial approach -- 10 Transcallosal approach -- 11 Endoscopic approaches for pineal region lesions -- 12 Management of Hydrocephalus -- III Adjuvant therapies -- 13 Radiosurgery -- 14 Other radiotherapeutic techniques -- 15 Chemotherapy -- IV Pineal region tumors -- 16 Tumors of Pineal Cell Origin -- 17 Tumors of germ cell origin -- 18 Tumors of glial origin -- 19 Meningiomas of the pineal region -- 20 Metastatic tumors -- V Vascular lesions of the pineal region -- 21 Arterio-venous malformations -- 22 Cavernomas.-23 Vein of Galen Aneurismal Malformation -- VI Cysts and Cyst -Like Lesions of the pineal region -- 24 Epidermoids and Dermoids -- 25 Pineal Cyst -- VII Miscellanea -- 26 Management algorithms -- 27 Conclusions.
    Abstract: Neurosurgical lesions of the pineal region are extremely rare, accounting for roughly 1% of the total number of neurosurgical expansive lesions in modern practice. This book offers an up-to-date review of the relevant literature, combined with the personal perspectives of some highly experienced figures in the field. The book is divided into two main parts, the first of which offers an overview of the pineal region from an anatomic, pathologic, imaging and therapeutic perspective. Special attention is given to surgical approaches to pineal region lesions. Microsurgical techniques are presented, together with detailed indications regarding specific locations of these lesions, specific complications, and controversial aspects concerning some of the approaches. A dedicated chapter addresses endoscopic techniques, their indications and limitations. Adjuvant therapies are also discussed, along with their particular indications and debated aspects. In turn, the chapters in the second part cover specific lesions such as pineal region tumors, vascular lesions, and cystic and cyst-like lesions. Regarding pineal region tumors, the most frequent pathologies are presented in the most comprehensive and practical manner possible, with special attention to the appropriate therapeutic management for each type. Further, there is a dedicated chapter on pineal region cysts. Given its depth of content, the book will allow neurosurgeons and specialists to greatly expand their understanding of pineal region lesions in daily clinical practice.
    Type of Medium: Online Resource
    Pages: XI, 260 p. 113 illus., 82 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030509132
    DDC: 617.48
    Language: English
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  • 2
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Microbiology. ; Diseases Causes and theories of causation. ; Microbial ecology. ; Bacteria. ; Epidemiology. ; Microbiology. ; Pathogenesis. ; Environmental Microbiology. ; Bacteria. ; Epidemiology.
    Description / Table of Contents: Chapter 1. Vibrio Infections and the Twenty-First Century -- Chapter 2. New Insights into Vibrio Cholerae Biofilms from Molecular Biophysics to Microbial Ecology -- Chapter 3. Type VI Secretion Systems: Environmental and Intra-Host Competition of Vibrio cholerae -- Chapter 4. Motility Control as a Possible Link Between Quorum Sensing to Surface Attachment in Vibrio Species -- Chapter 5. The Vibrio Polar Flagellum: Structure and Regulation -- Chapter 6. Environmental Reservoirs of Pathogenic Vibrio Spp. and Their Role in Disease: The List Keeps Expanding -- Chapter 7. Cholera Dynamics and the Emergence of Pandemic Vibrio cholerae -- Chapter 8. Role of Bacteriophages in the Evolution of Pathogenic Vibrios and Lessons for Phage Therapy -- Chapter 9. Vibrio vulnificus, an Underestimated Zoonotic Pathogen -- Chapter 10. The Role of Nutrients and Nutritional Signals in the Pathogenesis of Vibrio cholerae -- Chapter 11. Stress Responses in Pathogenic Vibrios and Their Role in Host and Environmental Survival -- Chapter 12. Vibrio parahaemolyticus Epidemiology and Pathogenesis: Novel Insights on an Emerging Foodborne Pathogen -- Chapter 13. The Viable but Non-Culturable (VBNC) State in Vibrio Species: Why Studying the VBNC State Now, Is More Exciting than Ever -- Chapter 14. Structural Insights into Regulation of Vibrio Virulence Gene Networks -- Chapter 15. When Vibrios Take Flight: A Meta-Analysis of Pathogenic Vibrio Species in Wild and Domestic Birds -- Chapter 16. What Whole Genome Sequencing Has Told Us About Pathogenic Vibrios.
    Abstract: This book addresses current topics on pathogenic Vibrio spp. from a comprehensive and holistic perspective. Here, experts in the field provide timely chapters, ranging from genomics, pathogen emergence, and epidemiology to pathogenesis, virulence regulation and host colonization. Questions addressed include: How does climate change affect the spread of these bacteria? What is the status of current vaccines? Are there novel therapeutic options to treat Vibrio infections? Is there likelihood of emergence of new pathogenic strains or species? Can insights from mathematical models and epidemiology lead to prediction of pathogen outbreaks? Recent decades have seen a steady increase in Vibrio spp. infections originating in aquatic and marine habitats, driven by higher human population densities, warming of polluted oceans, natural and human-made disasters, and mass seafood production. These conditions increase the likelihood of pathogenic Vibrio spp. coming into contact with humans, making their study even more timely and relevant as these problems escalate over time. This book is a valuable resource for health management professionals, experienced microbiologists/ microbial ecologists, and early career scientists alike who want to learn more about these important environmental human pathogens. The ideas and technologies presented in this book for preventing, controlling, and monitoring Vibrio spp. infections contribute to the UN Sustainable Development Goal 3: Good Health and Well-Being. .
    Type of Medium: Online Resource
    Pages: XI, 352 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031229978
    Series Statement: Advances in Experimental Medicine and Biology, 1404
    DDC: 579
    Language: English
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  • 3
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Veterinary medicine. ; Neurology . ; Anatomy. ; Neuroscience. ; Veterinary Science. ; Neurology. ; Anatomy.
    Description / Table of Contents: Introduction -- Rodent Taxonomic and biological data -- Basic Neurohistology -- Basic Neuroanatomy/ Coverings of the CNS/ Cerebrospinal fluid system -- Microscopic anatomy of the mouse brain -- The mouse spinal cord -- The mouse brainstem -- The mouse cerebellum -- The mouse dorsal thalamus -- The mouse hypothalamus.-The mouse cerebral cortex.-The mouse hippocampus.-The mouse amygdala -- The mouse caudate putamen -- The mouse oflactory system -- The mouse circle of Willis.
    Abstract: This textbook describes the basic neuroanatomy of the laboratory mouse. The reader will be guided through the anatomy of the mouse nervous system with the help of abundant microphotographs and schemata. Learning objectives and summaries of key facts at the beginning of each chapter provide the reader with an overview on the most important information. As transgenic mice are one of the most widely used paradigms when it comes to modeling human diseases, a basic understanding of the neuroanatomy of the mouse is of considerable value for all students and researchers in the neurosciences and pharmacy, but also in human and veterinary medicine. Accordingly, the authors have included, whenever possible, comparisons of the murine and the human nervous system. The book is intended as a guide for all those who are about to embark on the structural, histochemical and functional phenotyping of the mouse’s central nervous system. It can serve as a practical handbook for students and early researchers, and as a reference book for neuroscience lectures and laboratories. .
    Type of Medium: Online Resource
    Pages: XI, 350 p. 269 illus., 241 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030198985
    DDC: 612.8
    Language: English
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  • 4
    Online Resource
    Online Resource
    Berlin, Heidelberg :Springer Berlin Heidelberg :
    Keywords: Biotic communities. ; Human geography. ; Ecosystems. ; Human Geography.
    Description / Table of Contents: Introduction to Restoration Ecology - Which habitat should be restored? Reference ecosystems for restoration -- Measures for ecosystem restoration -- Reintroduction of plant and animal species -- For dealing with non-native species in ecosystem restoration -- Monitoring and success control -- Forests -- Moors -- Subalpine and alpine grasslands -- Running waters -- Natural and anthropogenic still waters - Ecosystems and types of use influenced by salt - Marine habitats in the North Sea and Baltic Sea - Heath in the lowlands and mountains - Meadows and pastures in mesophilic, moist and calcareous locations - Lean or dry sand grasslands of the coasts and des Inland areas - Fields - Traditional agroforestry systems - Urban ecosystems - Mining or open pit sites and landfills.
    Abstract: Bridging the natural and social sciences, this cross-disciplinary textbook comprehensively presents both the scientific basis of restoration ecology and practical aspects of ecosystem restoration. In doing so, it highlights the diversity of land-use types with a focus on Central Europe and presents case studies of practical restoration projects. The textbook provides a profound and up-to-date, but also critical overview of the state of knowledge for students dealing with the environment, scientists as well as practitioners. This book opens up the broad spectrum of degraded ecosystems of Central European natural and cultural landscapes. In further chapters, marine ecosystems and their restoration as well as development potentials but also limitations of ecosystem restoration are discussed in more detail. The ecological basics are extended by an interdisciplinary perspective taking into account environmental ethics, sociology, anthropology and economics. In addition to providing an up-to-date overview of the various fields and areas of activity in restoration ecology and ecosystem restoration, this textbook offers a valuable foundation for science, study and practice. Readers will also receive guidance on literature searches and critical fact analysis, and instructors on teaching in Higher Education and interdisciplinary approaches to discussions in restoration ecology. The author Stefan Zerbe is a landscape ecologist and teacher and researcher at the Free University of Bozen-Bolzano in South Tyrol (Italy). He is particularly interested in restoration ecology and building interdisciplinary bridges between the natural and social sciences. Against this background, he was in charge of developing and managing two international master’s programs. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent intense human revision was done primarily in terms of scientific terms, style and content so that the book will read stylistically differently from a conventional translation. Springer Nature works continuously to further the development of tools for the production of books and on the related technologies to support the authors.
    Type of Medium: Online Resource
    Pages: XXI, 723 p. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783662656587
    DDC: 577
    Language: English
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  • 5
    Keywords: Neuroanatomy. ; Anatomy. ; Neurosciences. ; Neuroanatomy. ; Anatomy. ; Nervous System. ; Neuroscience.
    Description / Table of Contents: PART I -- General consideration -- Development of the brainstem -- Rhombomere 11 r11 -- Rhombomere 10 r10 -- Rhombomere 9 r9 -- Rhombomere 8 r8 -- Rhombomere 7 r7 -- Rhombomere 6 r6 -- Rhombomere 5 r5 -- Rhombomere 4 r4 -- Rhombomere 3 r3 -- Rhombomere 2 r2 -- Rhombomere 1 r1 -- Isthmus r0 -- Mesencephalon m1 /m2 -- Pretectum p1 (Prosomere 1) -- PART II ATLAS -- Histology atlas of the human brain -- Darrow red series (Visualization of perikarya) -- Campbell series (Visualization of fiber tracts) -- Atlas of the human brainstem - magnetic resonance imaging (MRI) -- Topographical atlas of plastinated sections of the human brainstem and cranial nerve target structures.
    Abstract: The human brainstem has long been a neglected area in clinical medicine. This is shown by the fact that there is no introductory book on the neuroanatomy and pathology of this region. This book is intended to introduce the reader to the neuroanatomy of the human brainstem and combines an atlas with detailed information on the individual structures. The atlas features a state-of-the-art magnetic resonance imaging series, histological specimens (Darrow Red and Campbell staining) and a plastinate-based topographical part, which allows direct comparison of histological and topographical findings with neuroimaging. In addition, the reader is guided along the brainstem neuromer model through the human brainstem and learns about the functional properties of the individual structures of the brainstem. Where appropriate, peripheral targets of brainstem structures are illustrated and explained. Furthermore, each chapter covers the most important neurological disorders affecting the brainstem. This book aims to demonstrate that sound anatomical knowledge is required to understand brainstem pathology. It will particularly help those new to the field to better understand the complex anatomy of the human brainstem and will be useful to basic and clinical neuroscientists alike.
    Type of Medium: Online Resource
    Pages: XX, 697 p. 831 illus., 786 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783030899806
    DDC: 611.8
    Language: English
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  • 6
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Epigenetics. ; RNA Metabolism. ; Biochemistry. ; Bioinformatics. ; Epigenetics. ; RNA Metabolism. ; Biological Chemistry. ; Bioinformatics.
    Description / Table of Contents: Epitranscriptomic Modifications and How to Find them -- Epitranscriptomic Signature in Neural Development and Disease -- The Emerging Neuroepitranscriptome -- Epitranscriptomics and Diseases -- Epitranscriptomic Marks and Systems Involved in Gene Regulation, Development and Disease -- Experimental Approaches and Computational Workflows for Systematic Mapping and Functional Interpretation of RNA Modifications -- RNA Modifications: The Mediator Between Cellular Stresses and Biological Effects -- Computational Prediction and Experimental Validation of Specific Modified RNA Sites -- Regulation of RNA Stability Utilizing RNA Modification -- Dynamic RNA Modification Upon Extracellular Stimulus -- RNA Methylation in Cancer -- Regulation of RNA Methylation yy TET Enzymes -- RNA N6-Methyladenosine and G-Quadruplex Structures in Bacteria -- RNA N6-Methyladenosine Chemical Modification as a Therapeutic Target -- Cap-Adjacent m6Am and its Effects On mRNA -- N6-Methyladenosine in The Heart -- The m6a RNA Methylation Regulates Oncogenic Signaling Pathways Driving Cell Transformation and Carcinogenesis -- Psivar: A Database of Functional Variants Involved in Pseudouridylation (Ψ) with Implications for Disease Pathogenesis -- C-to-U RNA Editing by Mammalian APOBEC Enzymes -- The Powerful Mechanism of RNA Editing and its Therapeutic Potentials -- Noncanonical Caps in RNA -- Mass Spectrometry-Based Methods for Characterization of Hypomodifications in tRNA -- Dynamic mRNA Modifications in Plants -- The Mammalian Mitochondrial Epitranscriptome -- Epitranscriptomics Modifications of Micrornas: Classes, Detection, Impact on their Functionality and Next Frontiers -- “Look Before You Leap” when Editing the Introns, or the Secrets Behind the Intronic Post-Transcriptional Modification -- Functional Links Between the Internal N6-Methyl Adenosine Modifications in mRNAs and Human Diseases -- RNA Modifications in Neurodevelopment and Neurodegenerations -- Conventional and Advanced Techniques for Methyl-6-Adenosine Modification Mapping in Transcripts -- Mechanisms and Therapeutic Applications of RNA-Guided RNA Pseudouridylation -- Epitranscriptomic Modifications in lnRNA and miRNA in Cancer and Other Diseases -- RNA m6A and Adipogenesis.
    Abstract: This book reviews a novel and exciting field of cellular and molecular biology called epitranscriptomics, which focuses on changes in an organism’s cells resulting from the posttranscriptional modification of cellular RNA. RNA-binding proteins (RBPs) play a crucial role in these posttranscriptional modifications and also support several cellular processes necessary for maintaining RNA homeostasis. Exploring the mechanisms underlying RNA modifications and RBP function is an emerging area of biomedical research, taking the study of gene regulation a step beyond epigenetics. This book reveals that the RNA molecule is not just an information-carrying molecule with some secondary structures. Accordingly, how RNA is modified, regulated, packaged, and controlled is an important aspect. Leading experts address questions such as where the over 170 distinct posttranscriptional RNA modifications are located on the genome, what percentage of mRNAs and noncoding RNAs these modifications include, and how an RNA modification impacts a person’s biology. In closing, the book reviews the role of RNA modifications and RBPs in a variety of diseases and their pathogenesis. Addressing some of the most exciting challenges in epitranscriptomics, this book provides a valuable and engaging resource for researchers in academia and industry studying the phenomena of RNA modification.
    Type of Medium: Online Resource
    Pages: X, 632 p. 90 illus., 84 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030716127
    Series Statement: RNA Technologies, 12
    DDC: 572.865
    Language: English
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  • 7
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medical genetics. ; Biomaterials. ; Nucleic acids. ; Biotechnology. ; Medical Genetics. ; Nucleic Acid. ; Biotechnology.
    Description / Table of Contents: Long Non-Coding RNAs Diversity in Form and Function - from Microbes to Humans -- Evolving Roles of Long Noncoding RNAs -- Biogenesis and Function of the Noncoding Isoform-Type LncRNAs -- Long Non-Coding RNAs in a Single Cell Type: Function and Subcellular Localization -- Long Non-Coding RNAs as Scaffolds for Multiprotein Signalling Complexes -- Landscape of Long Non-Coding RNA Genes, Pseudogenes and Protein Genes in Segmental Duplications in the Critical Human Chromosomal Region 22q11.2 -- Long Non-Coding RNAs and Cancer Cells’ Drug Resistance: an Unexpected Connection -- Long Noncoding RNAs as Drivers of Acquired Chemoresistance in Hepatocellular Carcinoma -- Single Cell Analysis May Shed new Lights on the Role of LncRNAs in Chemo-Resistance in Gastrointestinal Cancers -- LncRNAs in the Development, Progression, and Therapy Resistance of Hormone-Dependent Cancer -- Tumorigenesis-Related Long Non-Coding RNAs and their Targeting as Therapeutic Approach in Cancer -- Long Non-Coding RNAs in Non-Small Cell Lung Cancer: State of the Art -- Long Non-Coding RNAs in Cardiovascular Diseases -- Long Non-Coding RNAs in Cardiovascular Development and Diseases.-Long Noncoding RNAs as Players in Breast Tumorigenesis -- Drosophila Models to Study Long Non-Coding RNAs Related to Neurological Disorders -- Regulatory Roles of Long Non-Coding RNAs in Skeletal Muscle Differentiation, Regeneration, and Disorders -- Long Noncoding RNAs in Substance Use Disorders -- The Multifaceted Roles of LncRNAs in Diabetic Complications: a Promising, yet Perplexing Paradigm -- Long Non-Coding RNAs in Diabetes and β-cell Regulation.
    Abstract: This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A large repertoire of ncRNAs, actively transcribed from the mammalian genome, control diverse cellular processes, both in terms of development and diseases, through a variety of gene regulatory mechanisms. IncRNAs have emerged as a new paradigm in epigenetic regulation of the genome. Given its scope, the book will be of particular interest to molecular, chemical, cell and developmental biologists, as well as specialists in translational medicine involved in disease-oriented research. It also offers a valuable resource for in silico experts seeking a deeper understanding of lncRNA expression and function through computational analysis of the NGS data.
    Type of Medium: Online Resource
    Pages: X, 545 p. 49 illus., 45 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030447434
    Series Statement: RNA Technologies, 11
    DDC: 616.042
    Language: English
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  • 8
    Keywords: Virology. ; Immunology. ; Human physiology. ; Vaccines Biotechnology. ; Biomaterials. ; Virology. ; Immunology. ; Human Physiology. ; Biomaterials-Vaccines.
    Description / Table of Contents: Varicella-zoster Virus - Genetics, Molecular Evolution, and Recombination -- The structures and functions of VZV glycoproteins -- Modulation of apoptosis and cell death pathways by Varicella zoster virus -- Modulation of host cell signaling pathways by varicella-zoster virus -- Modulation of MHC and MHC-like molecules by Varicella Zoster Virus -- Varicella Zoster Virus Neuronal Persistence and Reactivation modeled in-vitro -- Humanized Severe Combined Immunodeficient (SCID) Mouse Models for Varicella-Zoster Virus Pathogenesis -- Simian Varicella Virus: Molecular Virology and mechanisms of pathogenesis -- A guide to preclinical models of zoster-associated pain and postherpetic neuralgia -- Immune Responses to Varicella-Zoster Virus Vaccines -- Common features between stroke following varicella in children and stroke following herpes zoster in adults.
    Abstract: This edited volume provides insights about the molecular virology, pathoenesis of infection and host responses to varicella-zoster virus, which is a medically important human herpesvirus. The chapters not only discuss genetics and molecular evolution of the virus, but also new structure-based knowledge on the functions of viral glycoproteins. Further, the authors illustrate how mechanisms from the virus are used to take over and remodel host cells during pathogeneis. These mechanisms also enable viral modulation of host cells and evasion of the host immune response. Part of these evasion and survival strategies, is the reaction to triggered host cell responses like autophagy, the stress response, modulation of apoptosis and other cell death pathways. This hands-on knowledge is crucial for students and clinicians in Virology, Immunology, and Infectious Diseases. Chapter "Common features between stroke following varicella in children and stroke following herpes zoster in adults" is available open access under a Creative Commons Attribution 4.0 International License via Springerlink.com.
    Type of Medium: Online Resource
    Pages: VIII, 272 p. 39 illus., 32 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031153051
    Series Statement: Current Topics in Microbiology and Immunology, 438
    DDC: 579.2
    Language: English
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  • 9
    Keywords: Restoration Ecology. ; Landscape ecology. ; Environment. ; Applied ecology. ; Environmental education. ; Restoration Ecology. ; Landscape Ecology. ; Environmental Sciences. ; Applied Ecology. ; Environmental and Sustainability Education.
    Description / Table of Contents: Foreword -- Part I: Introduction – Traditional cultural landscapes in the world -- Part II: A sustainable balance between intensively and extensively used landscapes -- Part III: Traditional cultural landscapes on the world’s agenda -- Part IV: Restoration and revitalization of traditional cultural landscapes towards multifunctionality -- Part V: Case studies - Restoration of traditional cultural landscapes put into practice -- Part VI: Conclusions Take-home messages based on the book are shortly summarized. .
    Abstract: This book offers perspectives on how to develop a sustainable global balance of urbanization, land-use intensification, land abandonment, and multifunctional cultural landscapes. The focus is on the latter by describing the large variety of traditional cultural landscapes having evolved through centuries or even millennia by the use of the natural, terrestrial and aquatic resources. Those cultural landscapes encompass pasture, agroforestry, terraced, irrigation, coastal, monastic, and sacred landscapes as well as lake-, river-, and saltscapes. The restoration of low-input land-use systems which often carry a high biodiversity on the species, ecosystem, and landscape level as well as agrobiodiversity and agrodiversity is outlined. The restoration of multifunctional and diverse landscapes, however, is not only an ecological issue but encompasses many socio-economic aspects such as e.g., the revitalization of villages, eco-tourism, healthy food production, infrastructure, and rural-urban partnerships. Global environmental problems, which are related to urbanization and the intensification of the use of land and water resources are comprehensively outlined. Land abandonment which occurs on all continents is qualitatively and quantitatively assessed and the consequences for natural and cultural heritage loss is highlighted. With the presentation of current rural development and landscape conservation strategies on the national as well as international level, the topic reflects the high significance of environmental policy on the global scale. The global implementation of natural and cultural heritage conservation is, for example, given by the UNESCO World Heritage Sites, National Parks, Biosphere Reserves, Globally Important Agricultural Heritage Sites, High Nature Value Farmland, and the Satoyama initiative. However, also the “every-day” landscapes can contribute to biodiversity and strong sustainability. This comprehensive compendium, based on about 4,000 references of scientific studies, literature reviews, project reports, and environmental policy papers is thought for all students, scholars, and stakeholders from multifaceted disciplines, interested in multifunctional cultural landscapes and how traditions and innovation on the landscape level can be merged for a sustainable future on our planet. Case studies from all over the world are presented which can be used in Higher Education or to demonstrate the numerous approaches of sustainable rural development.
    Type of Medium: Online Resource
    Pages: XXIII, 716 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030955724
    Series Statement: Landscape Series, 30
    DDC: 333.7153
    Language: English
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  • 10
    Keywords: Neurosciences. ; Neurology . ; Pharmaceutical chemistry. ; Cognitive neuroscience. ; Neuroscience. ; Neurology. ; Pharmaceutics. ; Cognitive Neuroscience.
    Description / Table of Contents: Part I: Basic Science of Cerebellum and Ataxias -- Functional anatomy of the cerebellum -- Cerebellar physiology -- Cerebellar biochemistry/pharmacology -- Genetics of dominant ataxias -- Autosomal and X-linked degenerative ataxias: from genetics to promising therapeutics -- Seeking therapies for Spinocerebellar Ataxia: from gene silencing to systems-based approaches -- Ion Channel Genes and Ataxia -- Part II: Biomarkers and tools of trials -- How to Design a Therapeutic Trial in SCAs -- Therapy development for spinocerebellar ataxia: Rating Scales and Biomarkers -- Clinical rating scales for ataxia -- Scale for Ocular motor Disorders in Ataxia (SODA): Procedures and Basic Understanding -- Cerebellar learning in the prism adaptation task -- Blood and CSF biomarkers in autosomal dominant cerebellar ataxias -- Part III: Autosomal Dominant Cerebellar Ataxias -- Riluzole in progressive cerebellar ataxias -- ASOs against ATXN2 in preclinical and phase 1 trials -- Antisense oligonucleotide therapy against SCA3 -- Spinocerebellar ataxia type 7: From mechanistic pathways to therapeutic opportunities -- Experimental neurotransplantation for cerebellar ataxias -- Development of mesenchymal stem cells therapy for the treatment of polyglutamine SCA: from bench to bedside -- Cerebello-Spinal tDCS as Rehabilitative Intervention in Neurodegenerative Ataxia -- Cerebellar Transcranial Magnetic Stimulation in Cerebellar Ataxias -- Physical therapy in Cerebellar Ataxia -- Part IV: Autosomal Recessive Cerebellar Ataxias -- Recent advances on therapeutic approaches for Friedreich’s Ataxia -- Therapeutic use of interferon gamma in Friedreich ataxia -- Metabolic treatments of cerebellar ataxia -- Clinical Trials in Fragile X-Associated Tremor/Ataxia Syndrome -- Part V: Sporadic Ataxias -- Therapeutic strategies in immune-mediated cerebellar ataxias -- Coenzyme Q10 in MSA -- State of the Art and History of Therapeutics in Ataxias.
    Abstract: Despite the critical importance of the cerebellum in brain functions, the scientific community still lacks effective treatments for most cerebellar ataxias. This book provides a link between the pathogenesis and therapies of cerebellar ataxias while also providing a comprehensive assessment of the preclinical and clinical trials dedicated to cerebellar ataxias over the past 20 years of progress. This is the first book fully dedicated to the trials and therapies of these disorders. It is a truly authoritative and comprehensive reference and comes at a time of major advances in genetic tools and neuroimaging assessments. The coverage begins by laying a foundation of the basic science of the cerebellum and ataxias, proceeds to discuss biomarkers and the tools of trials, offers guidelines on conducting trials, and then explores the full range of therapeutics and their trials, including gene therapy and cell transplantation. The authors are top experts on cerebellar research and the contributing authors have all made seminal contributions in the field.
    Type of Medium: Online Resource
    Pages: XI, 727 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031243455
    Series Statement: Contemporary Clinical Neuroscience,
    DDC: 612.8
    Language: English
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