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  • 1
    Online Resource
    Online Resource
    Heat Shock Proteins of Malaria (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Parasitology. ; Proteins . ; Molecular biology. ; Cytology. ; Tropical medicine. ; Parasitology. ; Protein Biochemistry. ; Molecular Biology. ; Cell Biology. ; Tropical Medicine.
    Description / Table of Contents: Chapter 1. Introductory Chapter: The Importance of Heat Shock Proteins in Survival and Pathogenesis of the Malaria Parasite Plasmodium falciparum -- Chapter 2. General Structural and Functional Features of Molecular Chaperones -- Chapter 3. The Role of Hsp70s in the Development and Pathogenicity of Plasmodium falciparum -- Chapter 4. Role of the J Domain Protein Family in the Survival and Pathogenesis of Plasmodium falciparum. Chapter 5. Role of Hsp90 in Plasmodium falciparum Malaria -- Chapter 6. The Role of Malaria Parasite Heat Shock Proteins in Protein Trafficking and Remodelling of Red Blood Cells -- Chapter 7. Role of Heat Shock Proteins in Immune Modulation in Malaria -- Chapter 8. Bioprospecting for Novel Heat Shock Protein Modulators: The New Frontier for Antimalarial Drug Discovery? -- Chapter 9. Heat Shock Proteins as Targets for Novel Antimalarial Drug Discovery -- Chapter 10 -- Heat Shock Proteins of Malaria: Highlights and Future Prospects.
    Abstract: This new edition describes the role of heat shock proteins in the life cycle of malaria parasites, particularly in the context of intracellular parasite stages. Thoroughly revised, this work provides a general introduction to the structural and functional features of heat shock proteins with a special focus on their role as molecular chaperones in ensuring protein quality control. The emphasis is on the heat shock protein families from Plasmodium falciparum, and their role in proteostasis and the development of malaria pathology. Moreover, the authors explore the latest prospects of targeting heat shock proteins in antimalarial drug discovery either directly or in combination therapies. Readers will experience a functional analysis of the individual families of heat shock proteins and their cooperation in functional networks, including both the parasite-resident proteome and the exportome released into host cells during intracellular stages. Subcellular and extracellular organelles such as the apicoplast and the Maurer’s Clefts associated with Plasmodium species are discussed in detail. The book highlights the role of heat shock proteins in the development and function of these structures. Biochemical expertise and the inclusion of novel therapeutic solutions make this collection a unique reference for experts in heat shock protein research, parasitology and infectious diseases, cell stress, molecular biology and drug discovery. Not least, advances in malaria control will contribute to ending epidemics and ensuring healthy lives in line with the UN Sustainable Development Goals.
    Type of Medium: Online Resource
    Pages: XIII, 251 p. 26 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030783976
    Series Statement: Advances in Experimental Medicine and Biology, 1340
    URL: https://doi.org/10.1007/978-3-030-78397-6
    DOI: 10.1007/978-3-030-78397-6
    DDC: 571.999
    Language: English
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  • 2
    Monograph available for loan
    Monograph available for loan
    Sedimentary structures of ephemeral streams (1973)
    Amsterdam [u.a.] : Elsevier
    Associated volumes
    Details Availability
    Call number: 9/G 9176
    In: Developments in sedimentology
    Type of Medium: Monograph available for loan
    Pages: XVI, 223 S. : Ill., graph. Darst., Kt.
    Series Statement: Developments in sedimentology 17
    Language: English
    Location: Reading room
    Branch Library: GFZ Library
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  • 3
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    Sea2Cloud: from biogenic emission fluxes to cloud properties in the South West Pacific (2023)
    In:  Bulletin of the American Meteorological Society
    Details
    Publication Date: 2024-01-30
    Description: The goal of the Sea2Cloud project is to study the interplay between surface ocean biogeochemical and physical properties, fluxes to the atmosphere and ultimately their impact on cloud formation under minimal direct anthropogenic influence. Here we present an interdisciplinary approach, combining atmospheric physics and chemistry with marine biogeochemistry, during a voyage between 41 and 47°S in March 2020. In parallel to ambient measurements of atmospheric composition and seawater biogeochemical properties, we describe semi-controlled experiments to characterize nascent sea spray properties and nucleation from gas-phase biogenic emissions. The experimental framework for studying the impact of the predicted evolution of ozone concentration in the Southern Hemisphere is also detailed. After describing the experimental strategy, we present the oceanic and meteorological context including provisional results on atmospheric thermodynamics, composition, and flux measurements. In situ measurements and flux studies were carried out on different biological communities by sampling surface seawater from subantarctic, subtropical and frontal water masses. Air-Sea-Tanks (ASIT) were used to quantify biogenic emissions of trace gases under realistic environmental conditions, with nucleation observed in association with biogenic seawater emissions. Sea spray continuously generated produced sea spray fluxes of 34% of organic matter by mass, of which 4% particles had fluorescent properties, and which size distribution ressembled the one found in clean sectors of the Southern Ocean. The goal of Sea2Cloud is to generate realistic parameterizations of emission flux dependences of trace gases and nucleation precursors, sea spray, cloud condensation nuclei and ice nuclei using seawater biogeochemistry, for implementation in regional atmospheric models.
    Language: English
    Type: info:eu-repo/semantics/article
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  • 4
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    Current Advances in Meat Nutritional, Sensory and Physical Quality Improvement (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-04-05
    Description: Within the idea and objective of bringing together original studies dealing with the continuum aspects of meat, i.e., from farm to fork, this book grouped papers on the study of the nutritional, sensory, and technological aspects of carcass, muscle, meat, and meat-product qualities. This nook highlights a great part of the research activities in the field of meat science. A total of 14 original studies and one comprehensive review were edited within five main topics: (i) production systems and rearing practices, (ii) prediction of meat quality, (iii) statistical approaches for meat quality prediction/management, (iv) muscle biochemistry and proteomics techniques, and (v) consumer acceptability, development, and characterization of meat products.
    Keywords: QH301-705.5 ; Q1-390 ; TX341-641 ; meat quality ; sensory and technological quality ; serratus ventralis muscle ; modeling ; suckling cattle ; immunohistology ; pig ; carcass ; LC-MS/MS ; calpain ; sensorial and technological quality ; on-line ; infraspinatus muscle ; statistical tools for meat quality prediction ; malondialdehyde ; skeletal muscle ; chuck sale section ; male and female turkeys ; rearing managements ; dry-cured belly ; meat science ; breeders ; carcass characteristics ; production systems ; castration ; muscle biochemistry ; biomarker ; monitoring ; sample preparation ; quality ; bovine proteomics ; h2afx ; prediction ; broilers ; nutritional ; phenol ; shear force ; beef performances ; fetus ; complexus muscle ; near-infrared spectroscopy ; phenotypic model ; sensory acceptability ; cull cow ; trade-off ; meat sensory properties ; one-dimensional electrophoresis ; rhomboideus muscle ; boar taint ; OMICs tools ; pancetta ; longissimus muscle ; spectroscopy ; carcass and meat qualities ; finishing practices ; pre-weaning period ; grass-fed ; nutritional quality ; pasture ; consumer ; tenderness ; predictive model ; intramuscular fat ; fattening period ; rearing surveys ; rearing practices ; cows ; young bulls ; machine learning ; breed ; farm survey ; beef quality ; biological marker ; Folin-Ciocalteu ; decision trees ; natural antioxidant ; meat ; color attributes ; bovine ; processed meat ; meat rheological properties ; growth period ; muscle proteins ; extracellular matrix ; beef tenderness ; farm-to-fork ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
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  • 5
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    Water Isotopic Signature of Surface Snow Metamorphism in Antarctica (2021)
    Details
    Publication Date: 2022-04-01
    Description: Water isotope ratios of ice cores are a key source of information on past temperatures. Through fractionation within the hydrological cycle, temperature is imprinted in the water isotopic composition of snowfalls. However, this signal of climatic interest is modified after deposition when snow remains at the surface exposed to the atmosphere. Comparing time series of surface snow isotopic composition at Dome C with satellite observations of surface snow metamorphism, we found that long summer periods without precipitation favor surface snow metamorphism altering the surface snow isotopic composition. Using excess parameters (combining D,17O, and 18O fractions) allow the identification of this alteration caused by sublimation and condensation of surface hoar. The combined measurement of all three isotopic compositions could help identifying ice core sections influenced by snow metamorphism in sites with very low snow accumulation.
    Description: Plain Language Summary: Water isotopes in ice core records are often used to reconstruct past climate temperature variations. Classically, the temperature signal is thought to be imprinted in water isotopes of precipitation, and then archived in the ice core as it falls, and in cold areas of Antarctica, piles up for very long period. Here, we show that the surface snow isotopic composition varies in between precipitation events, suggesting that there might be more than one contribution to the isotopic signal in ice core records. This is particularly important for low accumulation sites, where the snow at the surface remains exposed for very long time periods. The combined use of several isotopic ratios in surface snow helps us disentangle the processes that create this signal.
    Description: Key Points: During summer without precipitation, intense snow metamorphism shows a strong water isotopic signature. During summer without precipitation, intense snow metamorphism shows a strong water isotopic signature. The d‐excess and 17O‐excess of the snow is a proxy of snow metamorphism for low accumulation regions.
    Description: FP7 Ideas: European Research Council (FP7 Ideas) http://dx.doi.org/10.13039/100011199
    Description: Foundation Prince Albert of Monaco
    Description: Alexander von Humboldt‐Stiftung (Humboldt‐Stiftung) http://dx.doi.org/10.13039/100005156
    Description: DFG project CLIMAIC
    Description: https://doi.pangaea.de/10.1594/PANGAEA.934273
    Keywords: ddc:551.31 ; ddc:551.9
    Language: English
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  • 6
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    The number of tree species on Earth (2022)
    In:  Proceedings of the National Academy of Sciences of the United States of America (PNAS)
    Details
    Publication Date: 2022-02-16
    Description: One of the most fundamental questions in ecology is how many species inhabit the Earth. However, due to massive logistical and financial challenges and taxonomic difficulties connected to the species concept definition, the global numbers of species, including those of important and well-studied life forms such as trees, still remain largely unknown. Here, based on global ground-sourced data, we estimate the total tree species richness at global, continental, and biome levels. Our results indicate that there are ∼73,000 tree species globally, among which ∼9,000 tree species are yet to be discovered. Roughly 40% of undiscovered tree species are in South America. Moreover, almost one-third of all tree species to be discovered may be rare, with very low populations and limited spatial distribution (likely in remote tropical lowlands and mountains). These findings highlight the vulnerability of global forest biodiversity to anthropogenic changes in land use and climate, which disproportionately threaten rare species and thus, global tree richness.
    Language: English
    Type: info:eu-repo/semantics/article
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  • 7
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    First Retrievals of Surface and Atmospheric Properties Using EnMAP Measurements over Antarctica (2023)
    In:  Remote Sensing
    Details
    Publication Date: 2023-08-21
    Description: The paper presents the first retrievals of clean snow properties using spaceborne hyperspectral observations via the Environmental Mapping and Analysis Program (EnMAP). The location close to the Concordia station at the Dome C Plateau (Antarctica) was selected. At this location, the atmospheric effects (except molecular light scattering and absorption) are weak, and the simplified atmospheric correction scheme could be applied. The ice grain size, snow specific surface area, and snow spectral and broadband albedos were retrieved using single-view EnMAP measurements. In addition, we propose a technique to retrieve trace gas concentrations (e.g., water vapor and ozone) from EnMAP observations over the snow surfaces. A close correspondence of satellite and ground-measured parameters was found.
    Language: English
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  • 8
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    Exploring the impact of dust-snow mixing structures on snow optical properties with a ray-tracing model (2023)
    In:  XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)
    Details
    Publication Date: 2023-05-23
    Description: Snow albedo determines the amount of incoming solar radiation that is reflected back into space. The presence of light-absorbing particles (LAPs) in snow, such as mineral dust, has been found to reduce snow albedo, leading to an enhanced warming of the snow and the underlying soil. This warming can cause snow and ice to melt, leading to further decreases in albedo and potential impacts on regional climate patterns and on water availability in snow-dominated areas. In the present study, we propose a novel approach to investigate the impact of mineral dust in snow. By means of a ray-tracing model, we accurately simulate light propagation in three-dimensional images of natural snow at the micrometer scale, in which dust particles are virtually added. In particular, we explore the effects of the microscopic dust-snow mixing structures, which can have a substantial impact on snow albedo reductions. We present here our first findings, including different mixing structures (external and internal) and LAP-snow-radiation interactions from microscopic and macroscopic (bulk snow optical properties) perspectives.
    Language: English
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  • 9
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    Altimetric Ku-band Radar Observations Simulated with SMRT (AKROSS) (2023)
    In:  XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)
    Details
    Publication Date: 2023-05-23
    Description: Sea ice thickness is essential for climate studies and numerical weather prediction. Radar altimetry has provided sea ice thickness measurement since the launch of ERS-1 and currently through CryoSat-2, but uncertainty arises from interactions between the emitted signal and snow cover on the ice surface. Snow and ice have been shown to affect the altimeter waveform mainly due to their microstructure properties, surface roughness and salinity. Therefore, modelling the scattering of the electromagnetic waves with the snowpack and ice is necessary to retrieve the sea ice thickness accurately. The Snow Microwave Radiative Transfer (SMRT) model can be used to simulate both snow cover and ice with salinity, which makes it suitable for modelling the altimeter waveform echo from the snow-covered sea ice. This work focuses on measurements made as part of the Altimetric Ku-band Radar Observations Simulated with SMRT (AKROSS) project. The AKROSS project was designed to provide the first evaluation of the SMRT model in altimeter mode for snow on sea ice. The purpose of this presentation is to evaluate SMRT in altimeter mode over sea ice by 1) evaluating the overall fit of the waveform with observations of CryoSat-2, 2) investigating the sensitivity of the Ku/Ka band for the CRISTAL mission of the European Space Agency (ESA).
    Language: English
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  • 10
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    Forward simulations of radar backscatter and brightness temperature from lake ice, and comparison with measurements from satellite altimetry missions (2023)
    In:  XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)
    Details
    Publication Date: 2023-06-27
    Description: Lake ice thickness (LIT) and lake water level (LWL) are two thematic products of lakes as an Essential Climate Variable (ECV). Lake water levels are routinely estimated using radar measurements from satellite altimetry missions, but the retrieval of LIT from such missions is relatively new. While there is growing interest in the production of climate data records of LIT through the processing of historical time series, there is a need to examine the impact of varying ice and overlying snow properties on radar altimetry and microwave radiometry measurements through full ice seasons. There is also recent realization that the presence of ice cover on lakes has an impact on the quality of LWL estimates for several weeks/months of the year. Thin ice during initial ice formation, the absence of snow on the ice surface, the presence of deformation features (i.e. cracks in the ice and pressure ridges), and snow/ice melt onset introduce uncertainty in the retrieval of LIT and LWL from state-of-the-art algorithms.This talk will present results from a study that examined the sensitivity of radar backscatter and microwave brightness temperature measurements from satellite altimetry missions to varying snow and ice properties on large northern lakes. The presentation will cover results from: 1) forward modelling experiments of brightness temperature (18-37 GHz) and backscatter/waveforms (3-36 GHz) using the Snow Microwave Radiative Transfer (SMRT) model linked to a thermodynamic lake ice model; and 2) the comparison of forward simulations of radar backscatter and brightness temperature with measurements from Sentinel-3 and Jason-3 missions.
    Language: English
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