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  • 1
    Unknown
    Basel, Boston, Berlin : Birkhäuser
    Keywords: Tsunami ; Pacific Ocean
    Description / Table of Contents: The 2011 Tohoku earthquake generated a catastrophic tsunami that killed nearly 20,000 people along the coast of Japan and caused the nuclear disaster at the Fukushima Daiichi Nuclear Power Plant. The tsunami propagated throughout the Pacific Ocean and also affected many other countries, including Russia, the USA, New Zealand, French Polynesia and Chile, demonstrating once again the terrible threat that tsunami waves pose for Pacific countries and the need for basin-wide international scientific collaboration. Following a brief introduction, this volume presents 21 scientific papers, including 12 on aspects of the 2011 Tohoku event. A first group of papers provides detailed field survey results from the coasts of Japan and Russia and examines the wave dynamics on the basis of these surveys, the source mechanism of the earthquake, and the far-field impacts of the Tohoku tsunami. The second group reports on the 2012 tsunamis in El Salvador, the Philippines, off the east coast of Honshu and the landmark Haida Gwaii event off the west coast of British Columbia, Canada, while the papers in a third set discuss a number of remaining challenging questions in tsunami science and warning. The volume will be of interest to scientists and practitioners involved in all aspects of tsunamis from earthquake source processes to transoceanic wave propagation and coastal impacts. Postgraduate students in geophysics, oceanography and coastal engineering – as well as those in the broader geosciences, civil and environmental engineering – will also find the book a valuable resource, as it combines recent case studies with the latest advances in tsunami science and natural hazards mitigation.
    Pages: Online-Ressource (VI, 366 Seiten)
    ISBN: 9783034808644
    Language: English
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  • 2
    Keywords: Tsunami ; Indian Ocean
    Description / Table of Contents: Ten years ago, on December 26, 2004, one of the world’s most destructive natural disasters occurred. A magnitude Mw 9.1 earthquake (third strongest ever instrumentally recorded) generated a global tsunami that killed about 230,000 people along the coasts of 14 countries in the Indian Ocean and propagated as far as the North Pacific and North Atlantic Oceans. Since then, various countries from around the globe contributed major funding to tsunami research and mitigation, enabling the installation of hundreds of new high-precision instruments, the development of new technology and the establishment of more modern communication systems. As a result, incredible progress has been achieved in tsunami research and operation during the ten years after the 2004 Indian Ocean tsunami. The papers presented in this second of two special volumes of Pure and Applied Geophysics reflect the state of tsunami science during this time, including two papers devoted to global observations. Five papers provide new findings specifically in the Indian Ocean. Eight papers cover Pacific Ocean studies, focusing mainly on the 2011 Tohoku earthquake and tsunami. Remaining papers in the volume describe studies in the Atlantic and Mediterranean and general tsunami source studies. The volume is of interest to scientists and practitioners involved in all aspects of tsunamis from earthquake source processes to transoceanic wave propagation and coastal impacts. Postgraduate students in geophysics, oceanography and coastal engineering – as well as students in the broader geosciences, civil and environmental engineering – will also find the book to be a valuable resource, as it combines recent case studies with advances in tsunami science and natural hazards mitigation.
    Pages: Online-Ressource (VI, 406 Seiten)
    ISBN: 9783034809597
    Language: English
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  • 3
    Keywords: Tsunami ; Indian Ocean
    Description / Table of Contents: This is the first volume of a collection of essays focusing on progress in tsunami science since the great tsunami of 26 December. A magnitude Mw 9.1 earthquake (third strongest ever instrumentally recorded) generated a global tsunami that killed about 230,000 people along the coasts of 14 countries in the Indian Ocean and propagated as far as the North Pacific and North Atlantic. Since then, various countries from around the globe contributed major funding to tsunami research and mitigation, enabling the installation of hundreds of new high-precision instruments, the development of new technology and the establishment of more modern communication systems. As a result, incredible progress has been achieved in tsunami research and operation during the ten years after the 2004 Indian Ocean tsunami. The papers presented in this first of two special volumes of Pure and Applied Geophysics reflect the state of tsunami science during this time. Eight papers are related to case studies highlighting regional hazards around the globe, while five papers record progress in tsunami warning systems. Benchmark studies that describe the accuracy of numerical models for tsunami impact, as well as a variety of inundation and generation studies, are presented by 7 additional papers.
    Pages: Online-Ressource (VI, 390 Seiten)
    ISBN: 9783034809115
    Language: English
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  • 4
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    Unknown
    Dortmund: Universität Dortmund, Sonderforschungsbereich 475 - Komplexitätsreduktion in Multivariaten Datenstrukturen
    Publication Date: 2018-12-07
    Description: Problem: Cigarette smoking is the most important risk factor of transitional cell carcinoma of the urinary bladder. The effect of the glutathione S- transferases M1 (GSTM1) and M3 (GSTM3) on the influence of this risk factor was investigated. Methods: A total of 293 bladder cancer patients from Dortmund and Wittenberg as well as 176 surgical patients without any malignancy from Dortmund were genotyped for GSTM1 und GSTM3 according to standard PCR/RFLP methods. Smoking habits were also qualified by a standardized interview. Results: The percentage of GSTM1 negative cases was 63 % in the entire bladder cancer patient group compared to 50 % in the control group. GSTM3*A/*A genotype was 76 % in the entire group of bladder cancer cases and 74 % in controls. Smokers and ex-smokers were overrepresented in the bladder cancer patient group. A significant association between smoking status and GSTM1 or GSTM3 genotype could not be revealed. Conclusion: The elevated percentage of GSTM1 negative bladder cancer cases shows the important effect of this polymorphic enzyme on the development of bladder cancer. In contrast to some other studies, an influence of GSTM1 on the risk due to cigarette smoking could not be observed.
    Keywords: ddc:330 ; Bladder cancer ; glutathione S-transferase M1 ; glutathione S-transferase M3 ; smoking
    Repository Name: EconStor: OA server of the German National Library of Economics - Leibniz Information Centre for Economics
    Language: English
    Type: doc-type:workingPaper
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  • 5
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    Unknown
    Dortmund: Universität Dortmund, Sonderforschungsbereich 475 - Komplexitätsreduktion in Multivariaten Datenstrukturen
    Publication Date: 2018-12-07
    Description: N-Acetyltransferase 2 (NAT2) genotyping may result in a considerable percentage in several ambiguous allele combinations. PHASE 2.1 is a statistical program which is designed to estimate the probability of different allele combinations. We have investigated haplotypes of 2088 subjects genotyped for NAT2 according to standard PCR/RFLP methods. In 856 out of 2088 cases the genotype was clearly defined by PCR/RFLP only. In many of the remaining cases the program clearly defined the most probable allele combination: In the case of *5A/*6C, *5B/*6A the probability for *5B/*6A is 99% whereas the alternative allele combination *5A/*6C can be neglected. Other combinations cannot be allocated with a comparable high probability. For example the allele combination *5A/*5C, *5B/*5D provides for *5A/*5C a probability of 69% whereas the estimation for *5B/*5D allele is only 31%. In the two most often observed constellations in our data [(*12A/*5B, *12C/*5C); (*12A/*6A, *12B/*6B, *4/*6C)] the probability of allele combination was ascertained as follows: *12A/*5B, 98%; *12C/*5C, 1.4% and *12A/*6A, 82%; *4/*6C, 17%; *12B/*6B, 0%. The estimation of the NAT2 haplotype is important because the assignment of the NAT2 alleles *12A, *12B or *13 as a rapid or slow genotype has been discussed controversially. Otherwise the classification of alleles in subjects which are not showing a clearly allocation can result in a rapid or slow acetylation state. This assignment has an important role in survey of bladder cancer cases in the scope of occupational exposure with aromatic amines.
    Keywords: ddc:330 ; PHASE 2.1 ; NAT2 genotyping ; single nucleotide polymorphism
    Repository Name: EconStor: OA server of the German National Library of Economics - Leibniz Information Centre for Economics
    Language: English
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  • 6
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    Unknown
    Dortmund: Universität Dortmund, Sonderforschungsbereich 475 - Komplexitätsreduktion in Multivariaten Datenstrukturen
    Publication Date: 2018-12-07
    Description: The determination of toxicokinetic parameters is an essential component in the risk assessment of potential harmful chemicals. It is a key step to analyse the processes involved in the formation of DNA adducts which are connected with the development of chemical-induced cancer. A general problem is the extrapolation of toxicological data from experimental animals to the human organism. Therefore a valid characterisation of the relevant processes for the whole species is required, i.e., of population mean parameters instead of sets of parameters for different individuals. These, again, may vary between repeated experiments at the same or at different administered doses. Nevertheless, these differences are of great importance in obtaining a more precise insight into the variability structure of process investigated within the test animal population, so that a valid basis for further research is the final result. The theory of hierarchical models, particularly the work of Racine-Poon (1985) and Racine-Poon and Smith (1990), provides a procedure which incorporates both, modelling of the variability structure and estimation of population mean parameter vectors. The present study was designed to elucidate interindividual and interoccasion variability of toxicokinetic parameters relevant for the biological transformation of one of the basic petrochemical industrial compounds, ethylene 2 (ethene), which is also a physiological body constituent, to its metabolite, ethylene oxide, which is a proven carcinogen.
    Keywords: ddc:310 ; Ethylene ; ethylene oxide ; toxicokinetics ; population model ; repeated measurements ; EM algorithm ; interindividual variability ; interoccasion variability
    Repository Name: EconStor: OA server of the German National Library of Economics - Leibniz Information Centre for Economics
    Language: English
    Type: doc-type:workingPaper
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