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Macrophage Targeted Delivery Systems : Basic Concepts and Therapeutic Applications (2022)

Gupta, Swati. [editor.] ; Pathak, Yashwant V. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Pharmacology. ; Pharmaceutical chemistry. ; Cytology. ; Toxicology. ; Immunology. ; Pharmacology. ; Pharmaceutics. ; Cell Biology. ; Toxicology. ; Immunology.

Beschreibung / Inhaltsverzeichnis: Part I Anatomy, Physiology and Pharmacology of Macrophages -- Introduction to Anatomy and Physiology of Macrophages from Drug Delivery Perspective -- Introduction to Pharmacology of Macrophages from Drug Delivery Perspective -- Mechanisms and Ways of Macrophage Delivery -- Macrophage Associated Disorders: Pathophysiology, Treatment Challenges and Possible Solutions -- Understanding Macrophage Associated Diseases and Applications of Nano Drug Delivery Systems -- Part II Polymeric Nanoparticles for Macrophage Targeting -- Targeting of Macrophages: Basic and therapeutic Role of Polymeric Nanoparticles -- Polymeric Nanoparticles Based Drug and Gene Delivery to Macrophages -- Surface Modification of Nanoparticles for Macrophage Targeting -- Part III Lipid Nanoparticles for Macrophage Targeting -- Liposomes as Delivery System for Macrophage Targeting -- Solid Lipid Nanoparticles Based Drug and Gene Delivery to Macrophages -- In vivo Fate of Colloidal Carriers Undergoing Macrophage Targeting -- Nanoparticle-based Theranostics for Macrophage-associated Diseases -- Part IV Targeting Macrophages for Treatment of Various Diseases -- Tumor Associated Macrophages as Therapeutic Target for Drug/immune Therapy of Cancer -- Macrophage Targeting for Therapy of Autoimmune Diseases -- Macrophage Targeting for Therapy of Cardiovascular Diseases (CVD) -- Macrophage targeting for therapy of intracellular infections -- Targeting Drugs and Nucleic Acids to Macrophages for Therapy of Inflammatory Diseases -- Macrophage Targeted Chemotherapy for Tuberculosis and other Respiratory Disease. -- Part V Specific Formulations and Clinical Trials on Macrophage Targeted Delivery -- Nano- and Microparticles Based Dry Powder Inhalers for Pulmonary Macrophage Drug Delivery -- Recent Trends in Clinical Studies on Macrophage Targeted Delivery -- Future Directions and Challenges in Macrophage Targeting. .

Kurzfassung: The proposed book is envisioned for the nascent and entry-level researchers who are interested to work in the field of drug delivery and its applications specifically for macrophage targeting. Macrophages have gained substantial attention as therapeutic targets for drug delivery considering their major role in health and regulation of diseases. Macrophage-targeted therapeutics have now added significant value to the lives and quality of life of patients, without undue adverse effects in multiple disease settings. We anticipate examining and integrating the role of macrophages in the instigation and advancement of various diseases. The major focus of the book is on recent advancements in various targeting strategies using delivery systems or nanocarriers followed by application of these nanocarriers for the treatment of macrophage associated disorders. Macrophage Targeted Delivery Systems is primarily targeted to Pharmaceutical Industry & Academia, Medical & Pharmaceutical Professionals, Undergraduate & Post graduate students and Research Scholars, Ph.D, post docs working in the field of medical and pharmaceutical sciences.

Materialart: Online-Ressource

Seiten: XVIII, 556 p. 76 illus., 73 illus. in color. , online resource.

Ausgabe: 1st ed. 2022.

ISBN: 9783030841645

URL: https://doi.org/10.1007/978-3-030-84164-5

DOI: 10.1007/978-3-030-84164-5

DDC: 615

Sprache: Englisch

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Biomedical Applications and Toxicity of Nanomaterials (2023)

Mohanan, P. V. [editor.] ; Kappalli, Sudha. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Pharmacology. ; Nanobiotechnology. ; Nanomedicine. ; Pharmacology. ; Nanobiotechnology. ; Nanomedicine and Nanotoxicology.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Macroporous cryogel-based systems for water treatment applications and Safety: nanocomposite-based cryogels and bacteria-based bioreactors -- Chapter 2. One dimensional Semiconducting Nanomaterials: Toxicity and Clinical Applications -- Chapter 3. Prospects of Safe use of Nanomaterials in Biomedicalapplications -- Chapter 4. Hyaluronic acid-based nanotechnologies for delivery and treatment -- Chapter 5. Theranostics nanomaterials for safe cancer treatment -- Chapter 6. Cardiovascular safety assessment of new chemical entities: current perspective and emerging technologies -- Chapter 7. Toxicology of pharmaceutical products during drug development -- Chapter 8. Safety and Risk assessment of food items -- Chapter 9. Non toxic Natural products as regulators of tumour suppressor gene function -- Chapter 10. Advancements in the safety of Plant medicine: Back to nature -- Chapter 11. Chemicals and their interaction in the aquaculture system -- Chapter 12. Zebrafish as a biomedical model to define developmental origins of chemical toxicity -- Chapter 13. Green synthesis of non toxic nanoparticles -- Chapter 14. Synthesis, characterisation and safety of titanium oxide nanoparticles -- Chapter 15. Characterisation of non toxic nanomaterials for biological applications -- Chapter 16. Toxicity assessment of nanoparticle -- Chapter 17. Safety of nanoparticles: emphasis on antimicrobial properties -- Chapter 18. Quantum dots for imaging and its safety -- Chapter 19. Genotoxicity evaluation of nanosized materia -- Chapter 20. Scaffoldmaterials and toxicity -- Chapter 21 Biological Safety and Cellular interactions of nanoparticles -- Chapter 22. Role of artificial intelligence in the toxicity prediction of drugs -- Chapter 23. Chemicals and rodent models for the safety study of alzheimer’s disease -- Chapter 24. Mitochondria-targeted liposomal delivery in Parkinson's disease: safety concerns -- Chapter 25. Routes of Nano-drug Administration and Nano-based drug delivery system and toxicity -- Chapter 26. Green Synthesised silver nanoparticles phytotoxicity and applications in agriculture: An overview -- Chapter 27 status of safety concerns of microplastic detection strategies -- Chapter 28. Impact of insecticides on man and environment.

Kurzfassung: This book covers the recent trends on the biological applications of nanomaterials, methods for their preparation, and techniques for their characterization. Further, the book examines the fundamentals of nanotoxicity, methods to assess the toxicity of engineered nanomaterials, approaches to reduce toxicity during synthesis. It also provides an overview of the state of the art in the application of Artificial intelligence-based methodologies for evaluation of toxicity of drugs and nanoparticles. The book further discusses nanocarrier design, routes of various nanoparticle administration, nano based drug delivery systems, and the toxicity challenges associated with each drug delivery method. It presents the latest advances in the interaction of nanoparticles with the cellular environment and assess nanotoxicity of these engineered nanoparticles. The book also explores the comparative and mechanistic genotoxicity assessment of the nanomaterials. This book is useful source of information for industrial practitioners, policy makers, and other professionals in the fields of toxicology, medicine, pharmacology, food, and drugs.

Materialart: Online-Ressource

Seiten: XVIII, 768 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789811978340

URL: https://doi.org/10.1007/978-981-19-7834-0

DOI: 10.1007/978-981-19-7834-0

DDC: 615

Sprache: Englisch

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Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology (2022)

Amponsah, Seth Kwabena. [editor.] ; Pathak, Yashwant V. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Pharmacology. ; Toxicology. ; Pharmaceutical chemistry. ; Pharmacology. ; Toxicology. ; Pharmaceutics.

Beschreibung / Inhaltsverzeichnis: Therapeutic and toxic concentration of drugs in biological matrices -- Analytical techniques for therapeutic drug monitoring and clinical toxicology -- Plasma therapeutic drug monitoring and clinical toxicology -- Dried blood spots in therapeutic drug monitoring and toxicology -- The role of artificial intelligence in therapeutic drug monitoring and clinical toxicity -- Therapeutic drug monitoring and optimal pharmacotherapy with medicines of narrow therapeutic index -- Therapeutic drug monitoring (TDM) and toxicological studies in alternative biological matrices -- Analyzing data from therapeutic drug monitoring, pharmacokinetics, and clinical toxicology studies -- Reducing toxicity in critically ill patients by using therapeutic drug monitoring -- Quality assurance of samples for therapeutic drug monitoring and clinical toxicology -- Therapeutic drug monitoring and toxicology of anticancer drugs -- Therapeutic drug monitoring and toxicology of immunosuppressant -- Therapeutic drug monitoring and toxicology: relevance of measuring metabolites -- Recent advances in nanosensors for Therapeutic Drug Monitoring (TDM) -- Organ toxicity by immunosuppressive drugs in solid organ transplantation -- Artificial intelligence-based techniques to assess drug toxicity in drug induced liver injury (DILI) disease -- Drug dose and therapy individualization -- Models for drug individualization: patient to population level -- Toxicity evaluation of nanomedicine -- Biochemical indices of drug toxicity -- Therapeutic drug monitoring and clinical toxicology: challenges and future directions.

Kurzfassung: This book gives an overview of therapeutic drug monitoring (TDM) and its clinical application. It also highlights recent advances in toxicological studies, as they relate to therapeutic drug monitoring. This is one of the few books available on the market that covers TDM. Therapeutic drug monitoring (TDM) is a clinical decision-making tool that enables dosage regimen adjustments based on clinical and laboratory measurements. TDM not only involves the measuring of drug concentrations but also interpretation of the results. There is a strong correlation between drug concentrations in body fluids and outcome than between dose and outcome. The chapters include coverage of analytical techniques, pharmacokinetics, therapeutic indices, artificial intelligence and recent advances in toxicological studies. The book fills a gap in published literature and provides reliable information on; Analytical techniques in TDM and clinical toxicology TDM and pharmacokinetic studies TDM of drugs with narrow therapeutic indices Artificial intelligence in TDM and clinical toxicology Future directions and challenges .

Materialart: Online-Ressource

Seiten: XVIII, 381 p. 43 illus., 41 illus. in color. , online resource.

Ausgabe: 1st ed. 2022.

ISBN: 9783031123986

URL: https://doi.org/10.1007/978-3-031-12398-6

DOI: 10.1007/978-3-031-12398-6

DDC: 615

Sprache: Englisch

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Emerging Technologies for Nanoparticle Manufacturing (2021)

Patel, Jayvadan K. [editor.] ; Pathak, Yashwant V. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Pharmacology. ; Nanotechnology. ; Nanochemistry. ; Pharmacology. ; Nanotechnology. ; Nanochemistry.

Beschreibung / Inhaltsverzeichnis: Part 1 Introduction and Biomedical Applications of Nanoparticles -- 1. Introduction to Nanomaterials and Nanotechnology -- 2. Biomedical Applications of Nanoparticles -- Part II-Polymeric Nanoparticles -- 3. Nanocrystallization and Nanoprecipitation Technologies -- 4. Microfluidics Technology for Nanoparticles and Equipment-. 5. Production of Nanocomposites via Extrusion Techniques -- 6. The Use of Supercritical Fluids Technologies for Nanoparticle Production -- 7. Salting out and Ionic Gelation Manufacturing Techniques for Nanoparticles -- 8. Nanogel Synthesis by Irradiation of Aqueous Polymer Solutions -- 9. Cellulose acetate based nanofibers: Synthesis, Manufacturing and Applications -- 10. Production of nanofibers, environmental challenges and solutions -- Part III-Lipid Nanoparticles -- 11. High Pressure Homogenization Techniques for Nanoparticles -- 12. Solvent emulsification evaporation and solvent emulsification diffusion techniques for nanoparticles -- 13. Ultrasound Activated Nanoemulsions -- 14. Multiple Emulsions: Emphasizing on industrial applications -- 15. Membrane techniques for the preparation of nanomaterials -- 16. Self-assembling Lipid Nanoparticles/Nanosystems (SLNN) using Hydrophilic Solvents: Overview and Industrial Uses -- 17. Nanoemulsions – An emerging technology in drug delivery -- Part IV- Metallic Nanoparticles -- 18. Manufacturing techniques for carbon nanotubes, gold nanoparticles and silver nanoparticles -- 19. Radio frequency (RF) plasma-based Synthesis of metallic Nano particles for Biomedical Application -- 20. Techniques for accurate sizing of nanoparticles -- 21. Silver nanoparticles synthesis from cyanobacteria: Environmental and biomedical applications -- 22. Selenium Nanoparticles: Green Synthesis and Exploitation -- Part V- Quality control for nanoparticles -- 23. Practical guidelines for the characterization and quality control of nanoparticlesin the pharmaceutical industry -- Part VI-Challenges in scale-up production of nanoparticles -- 24. Nanomedicine Scale-Up Technologies: Feasibilities and Challenges -- 25. Patent survey on recent technology for nanoparticles -- Part VII-Injectable Nanosystems -- 26. Injectable Nanosystems and Inherent Nano-Serum Interactions -- Part VIII- Future directions and challenges -- 27. Current Challenges and Future Directions in Nanomedicine.

Kurzfassung: This book provides an overview of nanoparticle production methods, scale-up issues drawing attention to industrial applicability, and addresses their successful applications for commercial use. There is a need for a reference book which will address various aspects of recent progress in the methods of development of nanoparticles with a focus on polymeric and lipid nanoparticles, their scale-up techniques, and challenges in their commercialization. There is no consolidated reference book that discusses the emerging technologies for nanoparticle manufacturing. This book focuses on the following major aspects of emerging technologies for nano particle manufacturing. I. Introduction and Biomedical Applications of Nanoparticles II. Polymeric Nanoparticles III. Lipid Nanoparticles IV. Metallic Nanoparticles V. Quality Control for Nanoparticles VI. Challenges in Scale-Up Production of Nanoparticles VII. Injectable Nanosystems VIII. Future Directions and Challenges Leading scientists are selected as chapter authors who have contributed significantly in this field and they focus more on emerging technologies for nanoparticle manufacturing, future directions, and challenges. .

Materialart: Online-Ressource

Seiten: XV, 611 p. 155 illus., 117 illus. in color. , online resource.

Ausgabe: 1st ed. 2021.

ISBN: 9783030507039

URL: https://doi.org/10.1007/978-3-030-50703-9

DOI: 10.1007/978-3-030-50703-9

DDC: 615

Sprache: Englisch

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Hydrological Modeling : Hydraulics, Water Resources and Coastal Engineering (2022)

Jha, Ramakar. [editor.] ; Singh, V. P. [editor.] ; Singh, Vivekanand. [editor.] ; [weitere]

Cham :Springer International Publishing :

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Schlagwort(e): Water. ; Hydrology. ; Earth sciences. ; Environmental engineering. ; Biotechnology. ; Bioremediation. ; Natural disasters. ; Sustainability. ; Water. ; Earth Sciences. ; Environmental Engineering/Biotechnology. ; Natural Hazards. ; Sustainability.

Beschreibung / Inhaltsverzeichnis: Performance improvement of usbr vi stilling basin model for pipe outlet -- Rain water harvesting for the main campus of jaipur national university, jagatpura, Jaipur -- Bio Inspired Genetic Algorithm for Optimal Design of Water Distribution Networks -- Drought assessment using various drought indices: a case study of banaskantha district -- Top surface soil moisture retrieval using c- band synthetic aperture radar over kudremukh grasslands -- Meteorological drought assessment in the bharathapuzha river basin -- Experimental and numerical analysis of mean pressure coefficient on C-shaped building with and without round corner. .

Kurzfassung: This book carefully considers hydrological models which are essential for predicting floods, droughts, soil moisture estimation, land use change detection, geomorphology and water structures. The book highlights recent advances in the area of hydrological modelling in the Ganga Basin and other internationally important river basins. The impact of climate change on water resources is a global concern. Water resources in many countries are already stressed, and climate change along with burgeoning population, rising standard of living and increasing demand are adding to the stress. Furthermore, river basins are becoming less resilient to climatic vagaries. Fundamental to addressing these issues is hydrological modelling which is covered in this book. Integrated water resources management is vital to ensure water and food security. Integral to the management is groundwater and solute transport, and this book encompasses tools that will be useful to mitigate the adverse consequences of natural disasters.

Materialart: Online-Ressource

Seiten: X, 526 p. 289 illus., 219 illus. in color. , online resource.

Ausgabe: 1st ed. 2022.

ISBN: 9783030813581

Serie: Water Science and Technology Library, 109

URL: https://doi.org/10.1007/978-3-030-81358-1

DOI: 10.1007/978-3-030-81358-1

DDC: 551.48

Sprache: Englisch

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River Hydraulics : Hydraulics, Water Resources and Coastal Engineering Vol. 2 (2022)

Jha, Ramakar. [editor.] ; Singh, V. P. [editor.] ; Singh, Vivekanand. [editor.] ; [weitere]

Cham :Springer International Publishing :

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Schlagwort(e): Water. ; Hydrology. ; Earth sciences. ; Natural disasters. ; Environment. ; Physical geography. ; Water. ; Earth Sciences. ; Natural Hazards. ; Environmental Sciences. ; Earth System Sciences.

Beschreibung / Inhaltsverzeichnis: Effect of bed permeability on flow turbulence in gravel-bed stream -- Study on Erosion and Undercut of Cohesive River Bank – An Experimental Approach -- Hydraulic design of reservoir in permeable pavement for mitigating urban storm water -- Analytical expression for measurement of discharge using conical obstruction in a small rectangular channel -- Efficient numerical algorithm for flow field around vertically submerged tandem and aligned circular cylinders. .

Kurzfassung: This book presents key principles of the hydraulics of river basins, with a unique focus on the interplay between stream flows and sediment transport. Addressing a number of basic topics related to the hydraulics of river systems, above all it emphasizes applicative aspects in order to provide the reader with a solid grasp of river engineering. The understanding of the river hydraulics is essential for the assessment of optimum locations for the conservation of water resources and its structures. This book will be interesting to readers and researchers working in the specialized area of river hydraulics of Ganga basin, Narmada, Tapi, Godavari, and other basins of India. It consists of review on hydraulics of meandering river; hydraulic design of reservoir in permeable pavement; optimization of hydraulic design; hydraulic investigations to optimize the design of spillway and design of energy dissipater; and analysis of performance of orifice spillway using computational fluid dynamics.

Materialart: Online-Ressource

Seiten: X, 471 p. 284 illus., 187 illus. in color. , online resource.

Ausgabe: 1st ed. 2022.

ISBN: 9783030817688

Serie: Water Science and Technology Library, 110

URL: https://doi.org/10.1007/978-3-030-81768-8

DOI: 10.1007/978-3-030-81768-8

DDC: 551.48

Sprache: Englisch

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Hydrological Extremes : River Hydraulics and Irrigation Water Management (2021)

Pandey, Ashish. [editor.] ; Mishra, S.K. [editor.] ; Kansal, M.L. [editor.] ; [weitere]

Cham :Springer International Publishing :

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Schlagwort(e): Water. ; Hydrology. ; Food security. ; Natural disasters. ; Environmental monitoring. ; Sustainability. ; Water. ; Food Security. ; Natural Hazards. ; Environmental Monitoring. ; Sustainability.

Beschreibung / Inhaltsverzeichnis: Intelligent Irrigation Water Management -- River Hydraulics -- Assessment and Monitoring of Hydrological Extremes -- Future Scenarios.

Kurzfassung: This book presents quality technical papers representing the recent developments in the field of hydrological modeling, water management and water governance including practical applications. The content covers multifarious aspects of hydrology and water resources. It includes an application of the Hydrologic Modelling System (HEC-HMS) which has been successfully demonstrated for assessment of floods. The authors suggest an approach for the mitigation of cyclone disaster through a case study of the Phailin cyclone, whilst considering mitigating pluvial flooding, developing suitable management strategies. The book includes chapters discussing the detrended fluctuation analysis which is carried out for multifractal description of droughts. Drought characteristics are analyzed, and drought indices evolved for drought preparedness/management. The use of science in community planning under changing climate is also studied and discussed. The authors present and experimental study wherein hydraulic coefficients are calibrated by using vertical orifice. A cross flow hybrid hydrokinetic turbine is also evaluated for performance, and high head regulating radial gate designed and studied its sensitivity. This book will appeal to researchers, field practitioners, NGO and other Governmental as well as private water practitioners .

Materialart: Online-Ressource

Seiten: XII, 446 p. 262 illus., 230 illus. in color. , online resource.

Ausgabe: 1st ed. 2021.

ISBN: 9783030591489

Serie: Water Science and Technology Library, 97

URL: https://doi.org/10.1007/978-3-030-59148-9

DOI: 10.1007/978-3-030-59148-9

DDC: 551.48

Sprache: Englisch

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