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  • Articles  (4)
  • Other Sources
  • Articles: DFG German National Licenses  (4)
  • Chemistry and Pharmacology  (4)
  • 1
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 116 (1921), S. 117-136 
    ISSN: 0863-1786
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' Zeitschrift für analytische Chemie 352 (1995), S. 380-384 
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Data are presented on the biochemical findings in several intermal organs from an Egyptian mummy with a 14C-dating of approximately 950 B.C. By use of radio immunoassay systems and gas chromatography/mass spectrometry, significant amounts of various drugs were detected in internal organs (lung, liver, stomach, intestines) as well as in hair, bone, skin/muscle and tendon. These analyses revealed a significant deposition of tetrahydrocannabinol (THC), nicotine (and its metabolite cotinine) and cocaine in the tissue from the mummy. The concentration profiles additionally provide evidence for the preferential ways of consumption: Thus, the highest levels of THC in lung specimens point to an inhalation of this drug — as it has been assumed from known ritual smoking ceremonies —, while nicotine and cocaine containing drugs showed their highest concentrations in the intestines and liver, so that they seem to have been consumed perorally. Furthermore, a histopathological examination of the internal organ tissues revealed some evidence for the underlying disease and the probable cause of death. Thus, a severe and presumably recurrent intravital pulmonary bleeding, most obviously due to a parasitosis affecting the lung, was observed.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0884-3996
    Keywords: Prostaglandin E1 ; endothelium ; polymorphonuclear leukocyte ; cell interaction ; adherence ; oxygen-derived metabolites ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: We investigated the effect of prostaglandin E1 on human polymorphonuclear leukocytes, in vivo. Polymorphonuclear leukocytes of a prostaglandin E1 and placebo study group were harvested and their function, as production of oxygen-derived metabolites and adherence to human cultured endothelial cells, was compared. Additionally, data obtained from polymorphonuclear leukocytes of a prostaglandin E1 and placebo group were compared with data obtained from polymorphonuclear leukocytes from 28 blood donors, who served as a control group.Production of oxygen-derived metabolites by polymorphonuclear leukocytes during contact with endothelial cells was measured by chemiluminescence. Chemiluminescence was significantly (p 〈 0.01) increased in the placebo group in comparison to the control group decreasing to values of control group after 6 d (post-trauma). Chemiluminescence response was not significantly suppressed in patients treated with prostaglandin E1 in comparison to the placebo group. Adherence of polymorphonuclear leukocytes (placebo group) to endothelial cells was significantly increased (p 〈 0.01) within the first 6 d post-trauma Following day 6, values were in the same range as values for the control group. Adherence was not significantly suppressed in patients treated with prostaglandin E1 in comparison to the placebo group. In conclusion, prostaglandin E1 at a dose of 20 ng/kg bw/min does not influence production of oxygenderived metabolites and adherence in polytraumatized patients in comparison to a placebo group. Additionally, production of oxygen-derived metabolites by polymorphonuclear leukocytes in response to endothelial cells is shown and it is evident that endothelial cells might influence production of oxygen derived metabolites by polymorphonuclear leukocytes.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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