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  • 1
    Online Resource
    Online Resource
    Synthetic Biology and iGEM: Techniques, Development and Safety Concerns : An Omics Big-data Mining Perspective (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Bioinformatics. ; Biotechnology. ; Data mining. ; Bioinformatics. ; Biotechnology. ; Data Mining and Knowledge Discovery.
    Description / Table of Contents: Chapter 1. Introduction to Synthetic Biology -- Chapter 2. iGEM: The Competition on Synthetic Biology -- Chapter 3. Synthetic Biology-related Multi-omics Data Integration and Data Mining Techniques -- Chapter 4. Synthetic Biology: Technical Issues -- Chapter 5. Synthetic Biology: Development Issues -- Chapter 6. Synthetic Biology: Safety Issues -- Chapter 7. Synthetic Biology: Data Resources, Web Services and Visualizations -- Chapter 8. Synthetic Biology: Case Studies -- Chapter 9. Concluding Remarks.
    Abstract: This book focuses on biological engineering techniques, multi-omics big-data integration, and data-mining techniques, as well as cutting-edge researches in principles and applications of several synthetic biology applications. Synthetic biology is a new research area, while it has been rooted from the long-established area including biological engineering, metabolite engineering, and systems biology. This book will discuss the following aspects: (1) introduction to synthetic biology and iGEM, especially focusing on the systematic design, rational engineering, and sustainability of design in the omics ages; (2) synthetic biology–related multi-omics data integration and data mining techniques; (3) the technical issues, development issues, and safety issues of synthetic biology; (4) data resources, web services, and visualizations for synthetic biology; and (5) advancement in concrete research on synthetic biology, with several case studies shown. Devised as a book on synthetic biology research and education in the omics age, this book has put focuses on systematic design, rational engineering, and sustainability of design for synthetic biology, which will explain in detail and with supportive examples the “What,” “Why,” and “How” of the topic. It is an attempt to bridge the gap between synthetic biology’s research and education side, for best practice of synthetic biology and in-depth insights for the related questions.
    Type of Medium: Online Resource
    Pages: XII, 113 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819924608
    URL: https://doi.org/10.1007/978-981-99-2460-8
    DOI: 10.1007/978-981-99-2460-8
    DDC: 570.285
    Language: English
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  • 2
    Online Resource
    Online Resource
    Cullin-RING Ligases and Protein Neddylation : Biology and Therapeutics (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Post-translational modification. ; Cytology. ; Biomedical Research. ; Post-translational Modifications. ; Cell Biology.
    Description / Table of Contents: Chapter 1 Introduction of Protein Ubiquitination and Cullin/RING Ubiquitin Ligases: introduce the protein ubiquitination system briefly; discuss the family of Cullin/RING Ubiquitin Ligases -- Chapter 2 Assembly and Regulation of CRL ubiquitin ligases: discuss the assembly process of CRL ubiquitin ligases by CAND1; elaborate the regulation of CRL ubiquitin ligases by neddylation -- Chapter 3 Protein structure of CRL and Neddylation complex -- Chapter 4 The roles of CRL ubiquitin ligases and neddylation in human diseases -- Chapter 5 The roles of CRL ubiquitin ligases in stem cell biology: Briefly introduce concept and potential application of stem cells; analyze a few example for CRL ubiquitin ligases to control stem cell biology -- Chapter 6 The biology of F-box proteins: introduce the history of SCF ubiquitin ligases; discuss the overall functions of F-box proteins (emphasize phospho-degron concept) -- Chapter 7 The roles of Fbxw7 in human diseases: discuss the roles of Fbw7 in cancer; elaborate the roles of Fbxw7 in other diseases -- Chapter 8 Mouse models of CRL1 components to study their biological function -- Chapter 9 Cullin2 and cancer: introduce Cullin2 ubiquitin ligases; discuss VHL ubiquitin ligase and its roles in cancer -- Chapter 10 Cullin3 and tumorigenesis: introduce Cullin3 ubiquitin ligases; discuss a few examples of Cullin3 ubiquitin ligases in control of tumorigenesis -- Chapter 11 Cullin4-DCAF proteins in tumorigenesis: Discovery of DCAF proteins; discuss a few examples of DCAF’s biological functions -- Chapter 12 Cullin4 ubiquitin ligases in DNA damage responses: Introduce Cullin4 ubiquitin ligases; discuss the roles of Cullin4 ubiquitin ligases in DNA damage responses -- Chapter 13 Coordinating the roles of Cullin5 ubiquitin ligases by SAG and UBE2F: introduce Cullin5 ubiquitin ligases; discuss how SGA and UBE2F mediates the functions of Cullin5 -- Chapter 14 Cullin5 in anti-virus infection: mechanism and drug target -- Chapter 15 The roles of Cul7 in cancer biology: introduce Cullin7 ubiquitin ligase7; discuss a few examples of Cullin7 ubiquitin ligases in cancer -- Chapter 16 Coordinating functions of p97 and CRL ubiquitin ligases in protein turnover: introduce the interactions between p97 and CRL ubiquitin ligases; discuss the coordinating roles between p97 and CRL ubiquitin ligases in protein turnover -- Chapter 17 Interaction between CRL ubiquitin ligases and COP9 Signalosome: introduce Cop9 signalosome; discuss how Cop9 signalosome regulates CRL ubiquitin ligases -- Chapter 18 Drug discovery effort to target Cullin-3 neddylation: discuss inhibitor of Cullin3 neddylation and its application -- Chapter 19 Targeting neddylation modification: Briefly introduce protein neddylation; discuss the roles of neddylation in cancer -- Chapter 20 Targeting CRL ubiquitin ligases: discuss current progress in targeting CRL ubiquitin ligases; discuss the application of CRL ubiquitin ligases in Protac drug development.
    Abstract: This book summarizes all the important aspects of CRLs (Cullin-RING E3 Ubiquitin Ligases), while providing details of mechanistic specifics that go beyond protein ubiquitination and neddylation. Ubiquitin ligases, including the CRLs, which are activated by neddylation, play an important role in diverse biological processes and are involved in various human diseases, particularly cancer. The book covers various topics, such as CRL structure, biology, genetics, its regulation by neddylation, its pivotal role in human disease, and its potential in drug discovery and targeted therapies. The book appeals to biochemists and biologists working in other fields, and, given the importance of CRLs in all aspects of cell biology and the great promise of targeting these complexes for therapy, is a valuable resource anyone interested in modern biology or medicine.
    Type of Medium: Online Resource
    Pages: VIII, 372 p. 119 illus., 68 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811510250
    Series Statement: Advances in Experimental Medicine and Biology, 1217
    URL: https://doi.org/10.1007/978-981-15-1025-0
    DOI: 10.1007/978-981-15-1025-0
    DDC: 610.72
    Language: English
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  • 3
    Online Resource
    Online Resource
    Advances in Hydrogen Sulfide Biology (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Physiology. ; Life sciences. ; Pharmacology. ; Biomedical Research. ; Physiology. ; Life Sciences. ; Pharmacology.
    Description / Table of Contents: Introduction -- Metabolism of endogenous H2S and its metabolites -- A common molecular switch for H2S to regulate multiple protein targets -- The protective role of H2S in the heart -- The proangiogenic effects of H2S -- H2S and the immune system -- Protection of H2S on the neurons -- The role of H2S in the metabolism of glucose and lipids -- Regulation of the ion channels by H2S -- The epigenetic mechanisms for H2S signalling -- The development of H2S donor.
    Abstract: Hydrogen sulfide (H2S) has emerged as an important gas signalling molecule in a series of organs/tissues, on the diseases of which it plays protective roles, such as proangiogenic effects in ischemic tissues, antiapoptotic effects in the cardiomyocytes, regularization of fatal arrhythmia in myocardial infarction, amelioration of inflammation in autoimmune diseases, modification of neuronal transmission, increase in sodium excretion from the kidney, and amelioration of insulin resistance, etc. This book focuses on the effect of hydrogen sulfide in cardiovascular system, immune system, nervous system, kidney, as well as on the metabolism of glucose and lipids and regulation of ion channels and so on. This book also provides the advances in the understanding of endogenous H2S metabolism and H2S protein targets, as well as H2S donors. It will benefit researchers in both academics and industry working on the underlying mechanism of H2S field and the future of translational medicine of H2S.
    Type of Medium: Online Resource
    Pages: IX, 236 p. 47 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811609916
    Series Statement: Advances in Experimental Medicine and Biology, 1315
    URL: https://doi.org/10.1007/978-981-16-0991-6
    DOI: 10.1007/978-981-16-0991-6
    DDC: 610.72
    Language: English
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  • 4
    Online Resource
    Online Resource
    New Nanomaterials and Techniques for Tumor-targeted Systems (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Nanotechnology. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Nanotechnology. ; Biomedical Research.
    Description / Table of Contents: 1 Introduction -- 2 Barriers for tumor drug delivery -- 3 Tumor-targeted strategies -- 4 Tumor-responsive drug release strategies -- 5 Tumor diagnosis patterns -- 6 Tumor therapeutic modes -- 7 Carbon-based tumor-targeted systems -- 8 Silica-based tumor-targeted systems -- 9 Lipid-based tumor-targeted systems -- 10 Dendrimer-based tumor-targeted systems -- 11 Polymer-based tumor-targeted systems -- 12 Other new tumor-targeted systems -- 13 Clinical applications of tumor-targeted systems -- 14 Challenges and perspectives of tumor-targeted systems.
    Abstract: This book summarizes the latest advances in nanomaterials and techniques in the field of tumor-targeted diagnosis and therapy. It provides valuable information for beginners and senior researchers, and stimulates new research directions by offering novel and provocative insights into the properties and technical principles of nanomaterials. The book systemically discusses the challenges in tumor treatment, current tumor-targeted strategies, drug-release strategies, diagnosis and therapeutic patterns, and also explores newly developed multifunctional nanomaterials and related systems.
    Type of Medium: Online Resource
    Pages: VI, 463 p. 72 illus., 63 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811551598
    URL: https://doi.org/10.1007/978-981-15-5159-8
    DOI: 10.1007/978-981-15-5159-8
    DDC: 571.978
    Language: English
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  • 5
    Online Resource
    Online Resource
    Molecularly Imprinted Polymers as Advanced Drug Delivery Systems : Synthesis, Character and Application (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Drug delivery systems. ; Biotechnology. ; Pharmacology. ; Drug Delivery. ; Biotechnology.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Synthetic Strategies for the Generation of Molecularly Imprinted Polymers -- Chapter 3. Special Control by Molecular Imprinting Materials-zero-order Sustained Release, Enantioselective MIPs and Self-regulated Drug Delivery Microdevices -- Chapter 4. Water Compatible Molecularly Imprinted Polymers -- Chapter 5. Stimuli Responsive Imprinted DDS -- Chapter 6. MIP as Drug Delivery Systems for Dermal Delivery -- Chapter 7. MIP as Drug Delivery Systems of Anticancer Agents -- Chapter 8. MIP as Dug Delivery Systems of Ophthalmic Drugs -- Chapter 9. MIP as Drug Delivery Systems for Special Application -- Chapter 10. Outlook.
    Abstract: This book summarizes the recent advancements for drug delivery systems (DDS) in terms of fundamental principles, rapidly emerging techniques and developing frontiers of molecular imprinting. Especially with the combination of enantioselective molecularly imprinted polymers and water compatible molecularly imprinted polymers, stimuli responsive imprinted DDS have been innovated and applied to dermal delivery, ophthalmic drugs and cancer treatment. This philosophy comprehensively revolutionizes the treatment strategy of human healthcare and provides the possibility to re-trigger in vivo an exhaust system after the complete release of the starting drug cargo, thus enabling precision medicine. To this end, the following unique features will be discussed and concluded: 1) State-of-the-art definition of MIP as drug delivery systems. 2) Advanced techniques and clinical applications of MIP as drug delivery systems in the past decade. 3) Novel frontiers and brand-new technologies, for example, drug delivery devices for zero-order sustained release and stimuli responsive imprinted DDS. 4) Revolutionary impact on dermal delivery, ophthalmic drugs and cancer treatment. 5) Future challenges and perspectives.
    Type of Medium: Online Resource
    Pages: VII, 216 p. 108 illus., 68 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811602276
    URL: https://doi.org/10.1007/978-981-16-0227-6
    DOI: 10.1007/978-981-16-0227-6
    DDC: 615
    Language: English
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  • 6
    Online Resource
    Online Resource
    The Centre of City: Urban Central Structure (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Human geography. ; Regional economics. ; Spatial economics. ; Human Geography. ; Regional and Spatial Economics.
    Description / Table of Contents: Introduction to the Urban Centrality Structure -- Development Models of the UC Structure -- Functional Analysis of the UC Structure Hierarchy -- Spatial Layout of the UC Structure -- UC Structure Planning.
    Abstract: This book presents the latest research results related to urban center and urban center. It expounds the theoretical connotation, development models, hierarchical function, and spatial layout of the urban central structure through over 200 figures and tables. In addition, it analyzes the threshold characteristics, structural hierarchy, spatial characteristics, and development rules of urban central structure through field research and quantitative researches on the major urban central structures in Asia. Meanwhile, how to solve the issue of construction and layout of urban central structure in planning and design practice is also covered. The book reveals the laws and spatial characteristics of urban central structure and provides a valuable guide both for urban designers and planners as well as researchers and students working in urban design and planning fields. It sheds new light on better understanding of the urban central structure.
    Type of Medium: Online Resource
    Pages: XV, 609 p. 505 illus., 392 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813366756
    URL: https://doi.org/10.1007/978-981-33-6675-6
    DOI: 10.1007/978-981-33-6675-6
    DDC: 304.2
    Language: English
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  • 7
    Online Resource
    Online Resource
    21st Century Maritime Silk Road: Wind Energy Resource Evaluation (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Oceanography. ; Energy policy. ; Energy and state. ; Physical geography. ; Water. ; Hydrology. ; Environmental sciences Social aspects. ; Ocean Sciences. ; Energy Policy, Economics and Management. ; Earth System Sciences. ; Water. ; Environmental Social Sciences.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Advantages and Disadvantages of Offshore Wind Energy -- Chapter 3. Research Progress of Offshore Wind Energy -- Chapter 4. Characteristics of Global Offshore Wind Energy -- Chapter 5. Climate Characteristics of Wind Energy in the Maritime Silk Road -- Chapter 6. Long Term Trend of Wind Energy in the Maritime Silk Road -- Chapter 7. Wind Energy Evaluation Around the Sri Lanka Waters -- Chapter 8. Future Focus of Wind Energy Evaluation.
    Abstract: This book aims to establish a wind energy evaluation system, to provide scientific reference for site selection, daily operation and long-term planning of wind power generation, thus to make contribution to breaking the shackles of power shortage. Firstly, it presents the advantages and disadvantages of offshore wind power, then further discusses about the status quo and challenges for wind power programs along the Maritime Silk Road and offer suggestions. A wind energy evaluation system was proposed with the Maritime Silk Road as a case study, including climatic features of wind power (temporal-spatial distribution), long-term climatic trend and mechanism, short-term forecast of wind energy, mid- and long-term projection of wind energy, technology of wind energy evaluation on key point or vital region and offshore wind energy dataset construction, to provide systematic and scientific reference for wind power evaluation and utilization. This book is one of the series of publications on 21st century Maritime Silk Road (shortened as “Maritime Silk Road”). It covers the characteristics of the marine environment and marine renewable energy, remote islands and reefs construction, climate change, early warning of wave disasters, legal escort, marine environment and energy big data construction, etc., contributing to the safe and efficient construction of the Maritime Silk Road. It aims to improve our knowledge of the ocean, thus, to improve the capacity for marine construction, enhance the viability of remote islands and reefs, ease the energy crisis and protect the ecological environment, improve the quality of life of residents along the Maritime Silk Road, and protect the rights, interests of the countries and regions participating in the construction of the Maritime Silk Road. It is a valuable reference for decision-makers, researchers, and marine engineers working in the related fields.
    Type of Medium: Online Resource
    Pages: XX, 177 p. 106 illus., 105 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811641114
    Series Statement: Springer Oceanography,
    URL: https://doi.org/10.1007/978-981-16-4111-4
    DOI: 10.1007/978-981-16-4111-4
    DDC: 551.46
    Language: English
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  • 8
    Online Resource
    Online Resource
    Stratigraphy Around the Permian–Triassic Boundary of South China (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Earth sciences. ; Evolution (Biology). ; Earth Sciences. ; Evolutionary Biology.
    Description / Table of Contents: 1 Introduction -- 2 Palaeogeographical settings of South China in the Changhsingian to Induan and palaeogeographic distribution of the studied Permian Triassic Boundary sections -- 3 Description of the studied Permian Triassic Boundary sections of South China -- 4 Age analysis and correlation -- 5 Temporal and spatial processes and dynamics of the Permian Triassic Boundary mass extinction (PTBME) in South China.
    Abstract: This book timely provides high-quality records of 32 PTB sections across different depositional settings from terrestrial to marine facies in South China, including descriptions of lithologies, high-resolution correlation of key boundaries and fossil occurrences at each section. This book also analyzes the patterns and processes of the community and ecosystem evolution over space and through time in the lead to the end-Permian mass extinction, and critically analyzes the mostly debated hypothesis, anoxia and volcanism, which were considered as the causes of mass extinction, based on the data from the studied sections of South China, together with materials from other regions of the world.
    Type of Medium: Online Resource
    Pages: XII, 287 p. 98 illus., 66 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819993505
    Series Statement: New Records of the Great Dying in South China,
    URL: https://doi.org/10.1007/978-981-99-9350-5
    DOI: 10.1007/978-981-99-9350-5
    DDC: 550
    Language: English
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  • 9
    Online Resource
    Online Resource
    Biogas Technology (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Refuse and refuse disposal. ; Renewable energy sources. ; Pollution. ; Agriculture. ; Industrial microbiology. ; Waste Management/Waste Technology. ; Renewable Energy. ; Pollution. ; Agriculture. ; Industrial Microbiology.
    Description / Table of Contents: Microoganism of anaerobic digestion -- Household digesters in rural area -- Biogas septic tanks -- Biogas plant -- Materials and structures of digesters -- Biogas cleaning -- Biogas storage -- Biogas utilization -- Digestate utilization.
    Abstract: This book focuses on agricultural waste treatment and renewable energy production from the perspective of anaerobic digestion. It covers topics on anaerobic digestion processes and practices in various types of biogas plant construction and management and systematically addresses the principle and main features of three kinds of anaerobic digestion systems: household digesters, biogas septic tanks, and biogas plants. Instructive, informative and easy to understand, the book offers a valuable asset for researchers, technicians, graduate students and managerial personnel working in the areas of renewable energy, agricultural ecological engineering and the treatment and utilization of agricultural wastes. .
    Type of Medium: Online Resource
    Pages: XV, 363 p. 119 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811549403
    URL: https://doi.org/10.1007/978-981-15-4940-3
    DOI: 10.1007/978-981-15-4940-3
    DDC: 363.728
    Language: English
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  • 10
    Online Resource
    Online Resource
    Flood Resources Utilization in the Yangtze River Basin (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Natural disasters. ; Environment. ; Human ecology Study and teaching. ; Earth sciences. ; Natural Hazards. ; Environmental Sciences. ; Environmental Studies. ; Earth Sciences.
    Description / Table of Contents: Introduction -- Necessity of the research -- General situation of the Yangtze River Basin -- Characteristic and Variation Analysis of Water and Sediment in Yangtze River Basin -- Feasibility Study of Flood Resources Utilization in Yangtze River Basin -- Feasibility Study on Flood Resources Utilization of the Three Gorges Project -- Study on flood resources utilization and risk countermeasures in the Yangtze River Basin -- Study on the Floating of the Operating Water Level of the Three Gorges Project in Flood Season -- Study on Small Flood Dispatching Mode in the Three Gorges Project -- Study on early impoundment at the end of flood season for the Three Gorges Project -- Study on the Risk Measures of Flood Resources Utilization in the three Gorges Project -- Conclusions and Suggestions.
    Abstract: This book is highly informative and carefully presented, providing scientific insights into the flood resources utilization in the Yangtze River Basin both for scholars and decision-makers. The book is for the purpose of analyzing the potential utilization of flood resources in the Yangtze River Basin and exploring effective ways to put forward the countermeasures against the risks. Major objectives of this book include: (1) revealing the characteristics of the inflow and the sediment variation in the upper reaches of the Yangtze River, quantitatively evaluating the potential utilization of the flood resources in the Yangtze River and demonstrating the feasibility of its utilization in the Basin; (2) proposing the necessity and feasibility of utilizing the flood resources by the Three Gorges Project; (3) shedding new light on the characteristics of the flood resources, presenting different methods of flood resources utilization in different regions over the Basin and raising the overall risk-optimized strategies of the flood resources utilization in the Yangtze River; (4) analyzing the risk of flood resources utilization for the Three Gorges Project regarding flood control, sediment, ecology, etc., and putting forward the risk-optimized countermeasures of flood resources utilization for the Three Gorges Project.
    Type of Medium: Online Resource
    Pages: XVI, 353 p. 61 illus., 49 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811581083
    URL: https://doi.org/10.1007/978-981-15-8108-3
    DOI: 10.1007/978-981-15-8108-3
    DDC: 551
    Language: English
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