ISSN:
0947-3440
Keywords:
Alkaloids
;
Enzyme catalysis
;
Oxidases
;
Peroxides
;
Acylations
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Agroclavine (1) was oxidized, by haloperoxidase from Streptomyces aureofaciens, to 2,3-dihydro-6,8-dimethyl-3β-acetoxy-8-ergolen-2-one (2) in the presence of sodium acetate and bromine ions. Acetate was incorporated into the above product during oxidation. In a propionate buffer, incorporation of propionate into the product was observed, yielding 2,3-dihydro-6,8-dimethyl-3β-propionoxy-8-ergolen-2-one (4). The biotransformation proceeded faster in the propionate buffer, affording also the higher oxidation product (4aS),(10bS)-7-amino-3,4,4a,5,6,10b-hexahydro-2,4-dimethyl-6-oxobenzo[f]quinoline (3).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.199719971129
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