ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary GM1 Gangliosidosis is an autosomal recessive genetic disorder due to deficiency of the lysosome enzyme beta-galactosidase, with consequent tissue accumulation of glycolipids, oligosaccharides, and especially GM1 ganglioside. In the present paper we report the clinical and laboratory findings obtained for eight families starting from eight index cases exhibiting the childhood form of the disease. The total number of cases in these families may be as high as 14, thus causing GM1 gangliosidosis to be the inborn metabolic error most frequently diagnosed in our service. Hypotonia, neuromotor retardation, hepatosplenomegaly, macrocephaly, and hydrocele are some of the most frequent clinical findings. The disease evolves towards convulsions and bronchopneumonia, leading to patient death generally during the first half of the second year of life. The presence of vacuolated lymphocytes, alterations of the lumbar vertebrae, and cherry spots on the retina were observed in almost all patients. When tested for inborn metabolic errors, all patients gave normal results, a fact that may have confused and delayed diagnosis. Diagnosis was made by urine oligosaccharide chromatography and confirmed by beta-galactoside measurement in peripheral blood leukocytes. This method proved to be accurate also for the detection of heterozygotes, which permitted post-mortem diagnosis in two families. The authors speculate that increased fetal loss and tendency towards macrosomy may be possible characteristics of the disease, suggest that testing for vacuolated lymphocytes be used as a screening method, and propose that urine oligosaccharide chromatography be included in the routine screening for inborn metabolic errors.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A dysmorphic 5-year-old girl with severe growth and mental deficiency was studied. She presented a de novo interstitial 2p deletion. Karyotype: 46,XX,del(2)(p13p15).
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1433-4909
    Keywords: Key words Compatible solutes ; Osmoadaptation ; Thermoadaptation ; α-Mannosylglycerate ; α-Mannosylglyceramide ; Rhodothermus marinus ; Rhodothermus obamensis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In this study we propose revised structures for the two major compatible solutes of Rhodothermus marinus. We have also examined the accumulation of compatible solutes by the type strains of the slightly halophilic and thermophilic species Rhodothermus marinus and Rhodothermus obamensis at several growth temperatures and salinities. The major solutes of R. marinus were identified as α-mannosylglycerate (α-MG) and α-mannosylglyceramide (α-MGA), whereas R. obamensis accumulated only α-mannosylglycerate. The total osmolyte content was higher during the early exponential phase and decreased abruptly as growth continued into the stationary phase. At low growth temperatures, R. marinus responded to water stress by accumulation of α-mannosylglycerate and its amide, in addition to low levels of trehalose, glutamate, and glucose. At the highest growth temperature, α-mannosylglycerate was the major compatible solute and α-mannosylglyceramide was not detected. When both compounds were present, an increase in the salinity of the growth medium favored the accumulation of α-mannosylglyceramide over α-mannosylglycerate. The absence of α-mannosylglyceramide in R. obamensis at all growth temperatures and salinities constituted the most pronounced difference in the profiles of compatible solute accumulation by the two strains. Trehalose was also a prominent solute in this organism. Both organisms accumulated higher levels of α-mannosylglycerate as the temperature was raised. The importance of the two compounds in the mechanisms of thermoadaptation and osmoadaptation is discussed.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 4
    Publication Date: 2019-04-18
    Description: Aiming for discovering effective and harmless antitrypanosomal agents, 17 essential oils and nine major components were screened for their effects on T. b. brucei. The essential oils were obtained by hydrodistillation from fresh plant material and analyzed by GC and GC-MS. The trypanocidal activity was assessed using blood stream trypomastigotes cultures of T. b. brucei and the colorimetric resazurin method. The MTT test was used to assess the cytotoxicity of essential oils on macrophage cells and Selectivity Indexes were calculated. Of the 17 essential oils screened three showed high trypanocidal activity (IC50 〈 10 μg/mL): Juniperus oxycedrus (IC50 of 0.9 μg/mL), Cymbopogon citratus (IC50 of 3.2 μg/mL) and Lavandula luisieri (IC50 of 5.7 μg/mL). These oils had no cytotoxic effects on macrophage cells showing the highest values of Selectivity Index (63.4, 9.0 and 11.8, respectively). The oils of Distichoselinum tenuifolium, Lavandula viridis, Origanum virens, Seseli tortuosom, Syzygium aromaticum, and Thymbra capitata also exhibited activity (IC50 of 10–25 μg/mL) but showed cytotoxicity on macrophages. Of the nine compounds tested, α-pinene (IC50 of 2.9 μg/mL) and citral (IC50 of 18.9 μg/mL) exhibited the highest anti-trypanosomal activities. Citral is likely the active component of C. citratus and α-pinene is responsible for the antitrypanosomal effects of J. oxycedrus. The present work leads us to propose the J. oxycedrus, C. citratus and L. luisieri oils as valuable sources of new molecules for African Sleeping Sickness treatment.
    Type: Article , PeerReviewed
    Format: text
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 5
    Publication Date: 2017-12-01
    Description: In spring 2016, joint IODP/ICDP Expedition 364 drilled into the peak ring of the Chicxulub crater, offshore the Yucatan Peninsula, Mexico. A continuous core was drilled (Hole M0077A) and recovered a sequence of Paleogene post-impact rocks, suevites, impact-melt rocks and granitic basement between 505.7 m and 1334.7 m below sea floor (bsf). The Chicxulub crater was formed ~66 million years ago by an impact. This catastrophic event was directly linked to a major mass extinction. For this study, we concentrate on the post-impact sediments (505.7 to 617.3 m bsf; ~48 to ~66 Ma). The main goal of drilling the post-impact section was to study the pace and mode of recovery of life in the ocean after the impact, and to analyze the paleoenvironmental changes across the Paleocene and Eocene. The late Paleocene and Eocene are characterized by a series of transient warming events, so-called hyperthermals that were associated with increased atmospheric pCO2. Here, we present preliminary geochemical and physical properties data from the ~112 m of Paleogene sediments. XRF data show high log (Ca/Ti) values between ~617 and ~598 m bsf (Paleocene and early Eocene), and lower values between ~598 and 505 m bsf. In particular the upper part is characterized by high-frequency fluctuations in log (Ca/Ti) reflecting repeated changes in lithology. These were presumably caused by Milankovitch cycles. Low log (Ba/Ti) values characterize the lowermost part of the record between ~617 and ~610, followed by a gradual increase to higher values, presumably indicating an increase in primary productivity towards the end of the Paleocene. Values remain at this higher level between ~605 and ~540 m bsf. Hyperthermals are characterized by strong positive log (Ba/Ti) peaks, likely pointing at highly elevated primary productivity levels during these short-lived events. Between ~540 and ~505 m bsf, log (Ba/Ti) values are more variable and drop occasionally to values as low as were encountered in the lowermost part. Similar to the log Ca/Ti curve, the log Ba/Ti curve is superimposed by high-frequency fluctuations. These fluctuations are also strongly visible in color reflectance measurements.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Conference , NonPeerReviewed
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Mice vaccinated with CL-14, a non-infective and non-pathogenic clone isolated from Trypanosoma cruzi CL strain, become protected against lethal challenge by infective trypomastigotes. It has been shown that animals infected with T. cruzi show polyclonal activation of B lymphocytes with an early production of several non-specific immunoglobulins. Vaccinated mice, however, have an early production of antigen-specific IgG1 and IgG2b. Considering the lack of infectivity of CL-14, our data strongly suggest a role for IgG1 and IgG2b in protection to T. cruzi.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 7
    ISSN: 1432-136X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary White (W), red (R), or combined (WR) tissue pieces from the myotomal musculature of the carp were incubated and some parameters of the carbohydrate metabolism followed, in basal conditions, and under the action of phloridzin, of insulin, or of adrenaline. 1. In WR pieces incubated in basal conditions, in glucose-free medium, the glycogen content dropped more in W than in R, free glucose content decreased only in W, lactate increased only in R (Fig. 1). In glucose containing medium, glycogen decreased only in W when incubated alone, but in both tissues of WR pieces. 2. Phloridzin elicited, in WR pieces, a supplementary drop of W glycogen, but reduced its decrease in R. Insulin moderated the glycogen loss of W (WR pieces); in glucose containing medium, it increased the glycogen and lactate content of R incubated alone, and diminished its content of reducing sugars. Adrenaline enhanced the glycogen loss of R, and increased its lactate concentration. 3. The results show a higher sensitivity of R than of W to insulin and adrenaline actions. 4. The results can be interpreted in terms of the hypothesis of a direct transfer of glucose from R to W, and of lactate from W to R.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 8
    ISSN: 1619-6937
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Description / Table of Contents: Zusammenfassung In der vorliegenden Arbeit wird ein mathematisches Modell für die Strömung eines ionisierten Gases in einer MHD-Kanalströmung gegeben. Die Voraussetzung ist hierbei, daß das äußere magnetische Feld lediglich in der Nähe der Elektroden wirkt. Der rechteckförmige Kanalquerschnitt hatN-Paare segmentierter Elektroden. Die Lösung wird in Form von Fourier-Reihen dargestellt und zwar getrennt im Bereich der Elektroden und der Isolatoren. Die Koeffizienten werden durch Bedingungen am Ende der Elektroden gegeben. Es werden die charakteristischen Eigenschaften des Generators hergeleitet sowie ein Rechenprogramm fürN=2 gegeben.
    Notes: Summary In this paper a mathematical model is given, for the flow of ionised gases in a channel of MHD conversion on the hypothesis that the external magnetic field is applied only in the zone of the electrodes. The rectangular cross-section channel carriesN pairs, of segmented electrodes. The solution is expressed in terms of Fourier series distinct in the electrode zones from those in the isolators zones. The coefficients are determined by the matching conditions at the ends of the electrodes. The characteristics of the generator are determined and a computing program forN=2 is given.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 9
    ISSN: 1432-0991
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. In an effort to elucidate the diversity of cyanobacterial hydrogenases, we used a molecular approach. Filamentous strains from a broad range of sources were screened for the presence of hup (uptake hydrogenase), xisC (rearrangement within hupL), and hox (bidirectional hydrogenase) genes. As expected, an uptake hydrogenase seems to be present in all N2-fixing cyanobacteria. On the other hand, no evidence was found for the presence of a conventional bidirectional enzyme in several strains. Similarly, the presence of xisC is not a characteristic shared by all the heterocyst-forming cyanobacteria. Although tempting, it is not possible to establish a correlation between the presence/absence of the bidirectional hydrogenase and the occurrence of xisC. The natural molecular variation of hydrogenases in cyanobacteria is certainly a field to explore, both to understand the physiological functions of the respective enzymes and to identify a genetic background to be used when constructing a strain for photobiological H2 production in a bioreactor.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 10
    Publication Date: 2018-07-03
    Description: En vista de la creciente competencia por el agua, existe el peligro que particularmente los pobres en las áreas rurales enfrenten cada día más dificultades para cubrir sus necesidades de agua para usos domésticos y productivos. El presente DIIS Working Paper fue elaborado con base a una encuesta llevada a cabo en el año 2008, en el municipio de Condega, Nicaragua; en él se expone un perfil de pobreza de los hogares rurales y se analiza el acceso al agua que tienen los hogares más pobres, menos pobres y no pobres; además de sus contactos con las instituciones que juegan un papel en la gobernanza de agua.
    Keywords: ddc:300
    Repository Name: EconStor: OA server of the German National Library of Economics - Leibniz Information Centre for Economics
    Language: Spanish
    Type: doc-type:workingPaper
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...