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  • 1
    Electronic Resource
    Electronic Resource
    Drug Release from Suppositories (1985)
    Springer
    Pharmaceutical research 2 (1985), S. 61-64 
    Details
    ISSN: 1573-904X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Many studies have been carried out over the past decades on suppositories and their drug release properties. The present state of knowledge is reviewed with the conclusion that our current understanding of the in vivo performance of suppositories is deficient. It is therefore not possible to rely on in vitro data to predict in vivo performance. Suggestions are presented for future studies that are required to enhance our knowledge of suppositiories as drug delivery systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016330409508
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  • 2
    Electronic Resource
    Electronic Resource
    Influence of Bloodflow on the Absorption of Theophylline from the Jejunum of the Rat (1984)
    Springer
    Pharmaceutical research 1 (1984), S. 23-27 
    Details
    ISSN: 1573-904X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The influence of the jejunal bloodflow on the absorption of theophylline was investigated. The bloodflow through a segment under investigation was varied by changing the systemic blood pressure by means of a donor blood infusion into the jugular vein or by an infusion of isoprenaline or levarterenol into a femoral vein, and was measured by collecting the venous outflow from the intestinal segment. Above a bloodflow of approximately 0.40 µl/min/cm the flux/ flow ratio is reduced, and it is proposed that above this flow the intestinal epithelium provides the rate limiting step in the absorption of theophylline. When the bloodflow was held low for a prolonged time, the flux of theophylline decreased. The absorptive site bloodflow was calculated to be 18 % of the total bloodflow through the segment under investigation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016374508542
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  • 3
    Electronic Resource
    Electronic Resource
    Rectal Motility and Bioavailability (1984)
    Springer
    Pharmaceutical research 1 (1984), S. 173-178 
    Details
    ISSN: 1573-904X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The contractile activity of the canine rectal wall exhibits a positive influence on the behaviour of fatty suppositories in vivo with respect to both spreading abilities and rate and extent of release of the readily water-soluble compound phenazone. This influence on bio-availability was marked when the drug was suspended in a large particle size (100–125 µm). When used in small particles (〈 35µm), far less influence of contractile activity was found. Small particles were equivalent to coarse particles with respect to the bioavailability. The addition of colloidal silicium oxide has a marked influence on spreading and bioavailability. Enhanced rectal motility exhibits an influence on the absorption only when a coarse fraction of the drug is suspended. It was concluded that rectal motility might be a cause of variation in bioavailability of drugs from rectal suppositories. For this reason only well-trained animals should be used when bioavailability of drugs from suppositories is tested in an animal model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016300708967
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  • 4
    Electronic Resource
    Electronic Resource
    Absorption of Etoposide (VP-16-213) from the Small Intestine of the Rat. The Potential Role of Mucus as an Absorption Rate Limiting Barrier (1985)
    Springer
    Pharmaceutical research 2 (1985), S. 162-165 
    Details
    ISSN: 1573-904X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The absorption of etoposide (VP-16-213) was investigated in a perfused intestinal loop. The absorbed amount of drug was determined by collecting the blood draining the loop via cannulation of the efferent jejunal vein. The absorption rate of VP-16-213 strongly depended on the composition of the perfusion medium. The addition of taurocholate to an aqueous etoposide solution enhanced the absorption rate. When N-acetylcysteine was added to an aqueous solution, the absorption rate dropped significantly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016331904482
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