ISSN:
1573-1111
Keywords:
SL2 type phase solubility diagrams
;
complex formation
;
chemical speciation
;
cyclodextrin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract A method is presented for the analysis of SL2-typephase solubility diagrams. Themethod allows the determination of individualcomplex formation and solubilityproduct constants through rigorous fitting of allsegments of the diagram: the risingportion, the plateau and the descending portion.Rigorous analysis of the descendingportion offers the means of discerning the typeof complex precipitate (SL or SL2). The method has been tested by computer simulation ofexperimental datafor both SL and SL2 complex precipitates. The limitsof precision of experimental datarequired to obtain reasonable estimates of equilibriumconstants have been exploredthrough superimposition of statistical random noise.The method has also beensuccessfully applied to the analysis of someexperimentally measured phase solubilitydiagrams that have been reported in the literature.These include the measuredsolubilities of 1,3-dimethylbenzoylurea (DMBU) againstcatechol concentration incarbon tetrachloride, tolbutamide (Tolb) against aqueousβ-cyclodextrin concentration,spironolactone (SP) against aqueous γ-cyclodextrinconcentration, in addition tomethylparaben, ethylparaben and propylparaben againstaqueous α-cyclodextrinconcentration at 25 °C.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1007965424219
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