Publication Date:
2011-01-22
Description:
(3 α ,5 α )-3-Hydroxy- C -homopregnane-11,20-dione ( 3 ) was prepared in eleven steps from the commercially available pregn-4-ene-3,11,20-trione ( 4 ) via the 11-oxo-13-formyl-12,13-secopregnane intermediate 11 ( Scheme 2 ). Subjection of this secopregnane to an intramolecular aldol condensation afforded the α , β -unsaturated key intermediate C -homopregn-12-en-11-one 12 .
Print ISSN:
0018-019X
Electronic ISSN:
1522-2675
Topics:
Chemistry and Pharmacology
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