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  • 1
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Biology Technique. ; Experimental immunology. ; Pharmaceutical chemistry. ; Medicine Research. ; Biology Research. ; Cytology. ; Clinical biochemistry. ; Immunological Techniques. ; Pharmaceutics. ; Biomedical Research. ; Cell Biology. ; Medical Biochemistry.
    Description / Table of Contents: Antibody-Drug Conjugates Basic Concepts and Structures -- Relationship between target and specific action of antibody-drugs conjugates -- The internalization and therapeutic activity of antibody drug conjugate -- The internalization and intracellular trafficking of ADC -- Distribution and metabolism of antibody-drug conjugates -- Application of Antibody fragments in ADCs -- Novel Targeting Carriers in Antibody-drug Conjugates -- Site-specified Conjugating Technology and Application -- Determination of drug-to-antibody ratio of ADCs -- Pharmacokinetic study of antibody-drug conjugates.
    Abstract: This book summarizes the related research achievements in Antibody-drug conjugates (ADCs) and their cell metabolism kinetics. The book has three main parts. The first part describes the basic theory of ADCs, including the basic concept and structure of ADCs, and the relationship between the targets of ADCs and their specific functions. The second part mainly introduces the endocytosis and intracellular metabolism of ADCs, including the relationship between endocytosis and ADC activity, the endocytosis and intracellular transport of ADCs, the distribution and metabolism of ADC in vivo. Then it discusses the new formats and research technology of ADCs, including the application of miniaturized antibodies in ADC synthesis, novel carriers for ADC design, the technology and application of site-specific conjugation, and approaches for analyzing the drug: antibody ratio (DAR), the study of pharmacokinetics of ADCs. This book combines the basic theory with the research technology. It can be used as a reference book for students, teachers and researchers of biomedical field.
    Type of Medium: Online Resource
    Pages: IX, 135 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811956386
    DDC: 571.96028
    Language: English
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  • 2
    Keywords: Pharmacology. ; Pharmacy. ; Biotechnology. ; Pharmacology. ; Pharmacy. ; Biotechnology.
    Description / Table of Contents: 1 Antiviral Drugs Against Herpesviruses -- 2 An Update on Antiretroviral Therapy -- 3 Structural Insights to Human Immunodeficiency Virus (HIV-1) Targets and their Inhibition -- 4 LEDGINs, Inhibitors of the Interaction between HIV-1 Integrase and LEDGF/p75, are Potent Antivirals with a Potential to Cure HIV Infection -- 5 Moving Fast Towards Hepatitis B Virus Elimination -- 6 Discovery and Development of Antiviral Therapies for Chronic Hepatitis C Virus Infection -- 7 Phytoconstituents as Lead Compounds for Anti-dengue Drug Discovery -- 8 Anti-influenza Drug Discovery and Development: Targeting the Virus and its Host by all -- 9 Search, Identification and Design of Effective Antiviral Drugs against Pandemic Human Coronaviruses -- 10 Peptide Based Antiviral Drugs -- 11 Covalent Antiviral Agents -- 12 Safe-in-Man Broad Spectrum Antiviral Agents -- 13 Exploiting Ubiquitin ligases for Induced Target Degradation as an Antiviral Strategy. .
    Abstract: This book summarizes state-of-the-art antiviral drug design and discovery approaches starting from natural products to de novo design, and provides a timely update on recently approved antiviral drugs and compounds in advanced clinical development. Special attention is paid to viral infections with a high impact on the world population or highly relevant from the public health perspective (HIV, hepatitis C, influenza virus, etc.). In these chapters, limitations associated with adverse effects and emergence of drug resistance are discussed in detail. In addition to classical antiviral strategies, chapters will be dedicated to discuss the non-classical drug development strategies to block viral infection, for instance, allosteric inhibitors, covalent antiviral agents, or antiviral compounds targeting protein–protein interactions. Finally, current prospects for producing broad-spectrum antiviral inhibitors will be also addressed. The book is distinctive in providing the most recent update in the rapidly evolving field of antiviral therapeutics. Authoritative reviews are written by international scientists well known for their contributions in their topics of research, which makes this book suitable for researchers not only within the antiviral research community but also attractive to a broad audience in the drug discovery field. This book covers molecular structures and biochemical mechanisms mediating the antiviral effects, while discussing various ligand design strategies, which include traditional medicinal chemistry, computational chemistry, and chemical biology approaches. The book provides a comprehensive review of antiviral drug discovery and development approaches, particularly focusing on current innovations and future trends.
    Type of Medium: Online Resource
    Pages: XI, 357 p. 142 illus., 64 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811602672
    Series Statement: Advances in Experimental Medicine and Biology, 1322
    DDC: 615
    Language: English
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  • 3
    Keywords: Bioinformatics. ; Biotechnology. ; Data mining. ; Bioinformatics. ; Biotechnology. ; Data Mining and Knowledge Discovery.
    Description / Table of Contents: Chapter 1. Introduction to Synthetic Biology -- Chapter 2. iGEM: The Competition on Synthetic Biology -- Chapter 3. Synthetic Biology-related Multi-omics Data Integration and Data Mining Techniques -- Chapter 4. Synthetic Biology: Technical Issues -- Chapter 5. Synthetic Biology: Development Issues -- Chapter 6. Synthetic Biology: Safety Issues -- Chapter 7. Synthetic Biology: Data Resources, Web Services and Visualizations -- Chapter 8. Synthetic Biology: Case Studies -- Chapter 9. Concluding Remarks.
    Abstract: This book focuses on biological engineering techniques, multi-omics big-data integration, and data-mining techniques, as well as cutting-edge researches in principles and applications of several synthetic biology applications. Synthetic biology is a new research area, while it has been rooted from the long-established area including biological engineering, metabolite engineering, and systems biology. This book will discuss the following aspects: (1) introduction to synthetic biology and iGEM, especially focusing on the systematic design, rational engineering, and sustainability of design in the omics ages; (2) synthetic biology–related multi-omics data integration and data mining techniques; (3) the technical issues, development issues, and safety issues of synthetic biology; (4) data resources, web services, and visualizations for synthetic biology; and (5) advancement in concrete research on synthetic biology, with several case studies shown. Devised as a book on synthetic biology research and education in the omics age, this book has put focuses on systematic design, rational engineering, and sustainability of design for synthetic biology, which will explain in detail and with supportive examples the “What,” “Why,” and “How” of the topic. It is an attempt to bridge the gap between synthetic biology’s research and education side, for best practice of synthetic biology and in-depth insights for the related questions.
    Type of Medium: Online Resource
    Pages: XII, 113 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819924608
    DDC: 570.285
    Language: English
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  • 4
    Keywords: Oceanography. ; Water. ; Hydrology. ; Renewable energy sources. ; Climatology. ; Physical geography. ; Ocean Sciences. ; Water. ; Renewable Energy. ; Climate Sciences. ; Earth System Sciences.
    Description / Table of Contents: Introduction -- Research progress of wave energy evaluation -- Temporal-spatial distribution of wave energy in the Maritime Silk Road -- Climatic trend of wave energy in the Maritime Silk Road -- Short-term forecast of wave energy in the Maritime Silk Road -- Long-term projection of wave energy in the Maritime Silk Road -- Wave energy assessment and proposal in the Sri Lankan waters -- Dataset construction of wave energy resources in the Maritime Silk Road -- Prospects of wave energy evaluation.
    Abstract: This book focuses on the evaluation of wave energy in the Maritime Silk Road. Firstly, it compares wave energy and other main energy sources, and then discusses the various disadvantages. It also presents the current research and the difficulties of wave energy evaluation, and systematically analyzes the climatic characteristics of the wave energy, including the temporal–spatial distribution and climatic trend of a series of key factors (e.g. wave power density, availability, richness, stability, energy direction, energy storage). It then describes the design of a short-term forecasting scheme and a long-term projection scheme of wave energy suitable for the Maritime Silk Road, to serve as a plan for the daily operation and long-term development of wave energy. Further, it highlights the wave energy analysis and decision-making in the context of the remote islands and reefs, using Sri Lanka is taken as a case study. Lastly, it presents the first wave energy resource dataset for the Maritime Silk Road. This book is one of a series of publications on the 21st century Maritime Silk Road (shortened as “Maritime Silk Road”) that covers the characteristics of the marine environment and marine new energy, remote islands and reef construction, climate change, early warning of wave disasters, legal escort, marine environment and energy big data construction, contributing to the safe and efficient construction of the Maritime Silk Road. It aims to improve our knowledge of the ocean, and so improve the capacity for marine construction, enhance the viability of remote islands and reefs, ease the energy crisis and protect the ecological environment and improve the quality of life of residents along the Maritime Silk Road, as well as to protect the rights, and interests of the countries and regions participating in the construction of the Maritime Silk Road. This book is a valuable reference resource for decision-makers, researchers, and marine engineers working in the related fields.
    Type of Medium: Online Resource
    Pages: XIX, 170 p. 95 illus., 94 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811509179
    Series Statement: Springer Oceanography,
    DDC: 551.46
    Language: English
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  • 5
    Keywords: Mineralogy. ; Geochemistry. ; Power resources. ; Petrology. ; Geology. ; Mineralogy. ; Geochemistry. ; Natural Resource and Energy Economics. ; Petrology. ; Geology.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Geological Setting -- Chapter 3. Petrological Characteristics and Sedimentary Environment -- Chapter 4. Mineralization Belts and Geological Characteristics of Deposits -- Chapter 5. Element Geochemistry -- Chapter 6. Ore-forming Fluids -- Chapter 7. Isotope Geochemistry -- Chapter 8. The Source and Regularity of Mineralization.
    Abstract: This book describes the mineralization process of barite-fluorite deposits in southeastern Sichuan, Yangtze Block, China. Mainly through systematic field geological surveys and detailed indoor research work, the typical barite-fluorite deposits in this area were analyzed using a variety of analysis methods such as single fluid inclusion LA-ICP-MS composition analysis, trace rare earth element analysis, H-O-S-Sr isotope analysis, F element content analysis, and Sm-Nd geochronological analysis. By in-depth analysis of the ore-forming environment, mineralization process and geological characteristics of barite-fluorite deposits, the following were determined: (1) the source of ore-forming fluids of barite-fluorite deposits and (2) the migration, concentration, enrichment, and evolution of ore-forming sources, exploring the formation mechanism of barite-fluorite deposits. Summarizing the mineralization regularity of the deposit in this area of China provides a new insight and basis for the study of similar types of deposits in the world.
    Type of Medium: Online Resource
    Pages: XXVIII, 190 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811675621
    Series Statement: Modern Approaches in Solid Earth Sciences, 23
    DDC: 549
    Language: English
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  • 6
    Monograph available for loan
    Monograph available for loan
    London [u.a.] : Routledge
    Call number: PIK B 333-19-93046
    Type of Medium: Monograph available for loan
    Pages: XXIII, 250 S. , Diagramme
    ISBN: 9781138017788 (hardback) , 9781315780191 (electronic)
    Series Statement: Routledge studies on the Chinese economy 55
    Language: English
    Note: Contents: 1 The Chinese population at a historic turning point ; 2 Socioeconomic development as a determinant of demographic transitions ; 3 Socioeconomic impacts of demographic transition ; 4 A steady approach to adjusting the family planning policy ; 5 Investing in health ; 6 Improving education ; 7 Child development in rural areas ; 8 An overall planning approach to the issue of population mobility in the future development of urban and rural areas ; 9 Promoting gender equality ; 10 Stimulating development potential in an aging society ; 11 Capacity building for family development ; Policy proposals
    Location: A 18 - must be ordered
    Branch Library: PIK Library
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  • 7
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 65 (1994), S. 3329-3331 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have studied the influence of interface roughness scattering on the mobility of two-dimensional electron gas (2DEG) in GaAs–AlGaAs modulation-doped heterostructures (MDH) both experimentally and theoretically. When the background ionized impurity concentration in the GaAs layer is smaller than 2.5×1015 cm−3, our investigation shows that interface roughness scattering is the dominant scattering mechanism in the high 2DEG density (Ns≥5×1011 cm−2) GaAs–AlGaAs MDH. We also demonstrate that interface roughness scattering is about an order of magnitude stronger than alloy disorder scattering in GaAs–AlGaAs MDH if the AlGaAs/GaAs interface fluctuation is only one monolayer of GaAs. © 1994 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: In GaAs/AlGaAs modulation-doped heterostructure, adopting triangular quantum well approximation and including the seven major scattering mechanisms, we considered the existence of the DX centers in the AlxGa1−xAs barrier and calculated the dependence of low-temperature two-dimensional electron gas (2DEG) density and mobility on spacer layer thickness, Al composition and Si-doping concentration of the AlxGa1−xAs barrier. The calculated results explained the experimental results that cannot be explained by the previous studies. Our calculations demonstrate that DX centers in the AlxGa1−xAs barrier play an important role in determining low-temperature 2DEG density and mobility. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 0277-5387
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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