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  • 1
    Electronic Resource
    Electronic Resource
    Embryology Does prepatterning occur in the mouse egg? (Reply) (2006)
    [s.l.] : Nature Publishing Group
    Nature 442.2006, 7099, E4-, (1 S.) 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Hiiragi et al. compare our model of the developing mouse egg with theirs. They seem to present patterning as equivalent to determination, but this is confusing as patterning does not have to mean determination. We have never stated that mouse embryo development is determined. Mouse ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature04908
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  • 2
    Electronic Resource
    Electronic Resource
    The first cleavage of the mouse zygote predicts the blastocyst axis (2005)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 434 (2005), S. 391-395 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] One of the unanswered questions in mammalian development is how the embryonic–abembryonic axis of the blastocyst is first established. It is possible that the first cleavage division contributes to this process, because in most mouse embryos the progeny of one two-cell blastomere ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature03388
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  • 3
    Electronic Resource
    Electronic Resource
    Jumping the gun on mouse gene expression (2000)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 405 (2000), S. 733-733 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Sir I am writing to correct a statement in the informative News Feature “A silence that speaks volumes” (Nature 404, 804; 2000). The work from my laboratory, published in the paper by Florence Wianny and myself, has ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35015787
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  • 4
    Electronic Resource
    Electronic Resource
    Role for sperm in spatial patterning of the early mouse embryo (2001)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 409 (2001), S. 517-521 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Despite an apparent lack of determinants that specify cell fate, spatial patterning of the mouse embryo is evident early in development. The axis of the post-implantation egg cylinder can be traced back to organization of the pre-implantation blastocyst. This in turn reflects the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35054069
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  • 5
    Electronic Resource
    Electronic Resource
    Histone arginine methylation regulates pluripotency in the early mouse embryo (2007)
    [s.l.] : Nature Publishing Group
    Nature 445 (2007), S. 214-218 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] It has been generally accepted that the mammalian embryo starts its development with all cells identical, and only when inside and outside cells form do differences between cells first emerge. However, recent findings show that cells in the mouse embryo can differ in their developmental fate ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature05458
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  • 6
    Electronic Resource
    Electronic Resource
    Mouse polo-like kinase 1 associates with the acentriolar spindle poles, meiotic chromosomes and spindle midzone during oocyte maturation (1998)
    Springer
    Chromosoma 107 (1998), S. 430-439 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. We have examined the dynamics of the localisation of the polo-like kinase 1 (Plk1) during maturation of the mouse oocyte. Levels of Plk1 protein increase following germinal vesicle breakdown, at which time the enzyme begins to accumulate at discrete positions on the condensing chromosomes and, subsequently, at the poles of the meiotic spindle, which moves towards the cortex of the egg. Interestingly, at metaphase in both meiotic divisions, Plk1 shows a punctate localisation along the broad spindle poles. Moreover, the punctate distribution of Plk1 on the meiotic chromosomes appears at early anaphase to correspond to the centromeric regions. The protein relocates to the spindle midzone during late anaphase and then associates with the midbody at telophase. We have confirmed the specific pattern of immuno-localisation seen in fixed preparations by observing the distribution of Plk1 tagged with green fluorescent protein in living oocytes. We discuss the localisation of the enzyme in light of the structure of the spindle poles, which are known to lack centrioles, and the highly asymmetric nature of the meiotic divisions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004120050327
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  • 7
    Electronic Resource
    Electronic Resource
    Activation of embryonic genes during preimplantation rat development (1994)
    New York, NY [u.a.] : Wiley-Blackwell
    Molecular Reproduction and Development 38 (1994), S. 30-35 
    Details
    ISSN: 1040-452X
    Keywords: Rat embryo ; Transcription ; Protein synthesis ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Expression of the embryonic genome has been examined during preimplantation rat development. Proteins synthesized at different stages of embryogenesis were labelled with [35S]methionine and then separated by one-dimensional gel electrophoresis. A major transformation in the pattern of protein synthesis has been observed between the two- and the four-cell stages of embryonic development. Also the culture of embryos with an inhibitor of transcription (α-amanitin) has shown that the first α-amanitin-sensitive events take place during the late two-cell stage. However, inhibition of transcription does not arrest the embryo development up to the four-cell stage. Taken together, the results indicate that in rats the initiation of embryonic gene activation occurs at the late two-cell stage. However, the first two cleavage divisions can occur in the absence of transcription. © 1994 Wiley-Liss, Inc.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrd.1080380106
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  • 8
    Electronic Resource
    Electronic Resource
    Cytoskeletal organization of rat oocytes during metaphase II arrest and following abortive activation: A study by confocal laser scanning microscopy (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Molecular Reproduction and Development 35 (1993), S. 165-175 
    Details
    ISSN: 1040-452X
    Keywords: Microtubles ; microfilaments ; Microtublel-organizing centers ; Parthenogenetic activation ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: In metaphase II arrested rat oocytes (M il), microtubles were found in the taper-shaped meiotic spindle and in the cytoplasm as asters and free microtubules. Whereas spindle microtubules were acetylated, those located in the cytoplasm were not. Cytoplasmic microtubules were also labile as assessed by mild cooling. In contast to mouse oocytes, rat microtubule organizing centers (MTOCs) did not react with MPM-2 antibody by immunofluorescence despite the fact that this antibody reacts with several proteins as shown by immunoblot. However, cytoplasmic MTOCs in M II-arrested rat oocytes could be detected by their nucleating capacity in the presence of taxol, a drug that induced the formation of numerous cytoplasmic asters. In addition, taxol caused a change in the spindle shape and the formation of astral microtubules at the spindle poles. Meiotic spindles (as well as chromosomes devoid of microtubules after nocodazoletreatment) were overlaid by an actin-rich domain. Spontaneous abortive activation led to the extrusion of the second polar body followed by another metaphase arrest -  metaphase III; however, normal spindles did not form and dispersed chromosomes surrounded by microtubles were observed. Electron microscopic studies confirmed these observations and revealed that the kinetochores are located deep within the chromosomes in contrast to mouse kinetochores, and this might be responsible for the absence of a metaphase III spindle in the rat oocyte. Induced activation caused transition to interphase with the formation of a characteristic microtubule network. This study shows that there are several significant differences in the cytoskeletal organization of rat and mouse oocytes. © 1993 Wiley-Liss, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrd.1080350210
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  • 9
    Electronic Resource
    Electronic Resource
    Spontaneous and induced activation of rat oocytes (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    Molecular Reproduction and Development 28 (1991), S. 169-176 
    Details
    ISSN: 1040-452X
    Keywords: Parthenogenesis ; Puromycin ; Chloral hydrate ; Handling procedures ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Ovulated rat oocytes undergo spontaneous activation during in vitro culture. After extrusion of the second polar body, they do not enter interphase but are arrested again in next metaphase-like stage (M III arrest). The present study demonstrates that puromycin and chloral hydrate can trigger transition to interphase of metaphase II and spontaneously (incompletely) activated rat oocytes. The response of oocytes to these activators depends on their stage at the time of application of a stimulus. Metaphase II oocytes enter interphase at 86.8% when treated with puromycin and in 28.7% after chloral hydrate activation. Oocytes activated with chloral hydrate at the time of spontaneously induced anaphase II enter interphase at 64.8%, but after reaching the stage of telophase II their capability to shift to interphase is again low (28.8%). Finally, M III oocytes cannot be forced to enter interphase by either chloral hydrate or puromycin treatment. This study shows that resumption of the second meiotic division and transition to interphase--the two processes that normally occur in succession as a response to oocyte activatin--can be experimentally separated.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrd.1080280210
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  • 10
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    Histone arginine methylation regulates pluripotency in the early mouse embryo (2007)
    Springer Nature
    Details
    Publication Date: 2007-01-01
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Springer Nature
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