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  • 1
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Polymorphisms and haplotypes at the adjacent apolipoprotein (apo) AI and CIII gene loci were investigated in 61 Japanese patients with triglycerides greater than 350 mg/dl and in 66 unrelated normolipidemic subjects. The polymorphic sites were the SstI site in the apoCIII 3′ untranslated region, whose presence has previously been shown to be associated with hypertriglyceridemia (HTG) in Caucasians, and the MspI site in the third intron of the apoAI gene. The frequencies of the SstI minor allele (S2) were 0.48 in HTG patients and 0.25 in normolipidemic subjects (P 〈 0.00015). The frequencies of the MspI minor allele (M2) were 0.61 in HTG patients and 0.33 in normolipidemic subjects (P 〈 0.00001). The two polymorphic sites were in strong linkage disequilibrium, and maximum likelihood analysis supported the existence of three of the four possible haplotypes: S1-M1, S1-M2, and S2-M2. Since all S2 alleles were estimated to be present on M2-bearing chromosomes, the HTG-associated S2-M2 haplotype conferred the same approximate relative risk as the S2 allele alone when compared with the other two haplotypes (odds ratio 2.8). This study demonstrates that the S2 allele is a marker for HTG among west Japanese subjects as well as among Caucasians. The results suggest that S2-M2 chromosomes carry HTG susceptibility sequences that predate the separation of the Asian and Caucasian races.
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 324-325 (Nov. 2006), p. 153-156 
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The influence of different cooling techniques and storage temperatures (-1.5 °C or 1.5 °C) to prolong the shelf life of shrimp was evaluated by sensory analysis, physical methods, chemical analysis, and microbial analysis. Storage in liquid ice was more effective than flake ice or brine mixed with flake ice in delaying spoilage of the shrimp by slowing down microbial growth and formation of total volatile basic nitrogen (TVB-N) and trimethylamine (TMA). Total viable counts (TVC) showed that bacteria grew most quickly in shrimp stored in flake ice and in brine mixed with flake ice, followed by those in liquid ice at 1.5 °C and -1.5 °C, respectively. Lowest counts were observed in shrimp stored in liquid ice at -1.5 °C where the lag phase of growth was apparently extended at the beginning of storage. Principal component analysis (PCA) showed a good correlation between quality indicators related to microbial growth, TVC, pH, TVB-N, TMA, responses of an electronic nose and sensory evaluation.
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  • 4
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Fungi exist in every indoor and outdoor environment. Many fungi are toxigenic or pathogens that may cause various public health concerns. Rapid and accurate detection and identification of fungi require specific markers. In this study, partial mitochondrial large subunit rDNA was amplified and sequenced from 32 fungal strains representing 31 species from 14 genera. Based on the sequence variation pattern, 26 oligonucleotide probes were designed for their discrimination. The specificity of the probes was evaluated through homology search against GenBank database and hybridization examination on 38 fungal strains. The 26 probes were verified as highly specific to 20 fungal species. A two-step detection procedure through PCR followed by probe hybridization gave ten-fold increase in detection sensitivity than single-step PCR assay and would be a practical approach for environmental sample screening. The probes developed in this study can be applied in clinical diagnosis and environmental monitoring of fungal agents.
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 561-565 (Oct. 2007), p. 1455-1458 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: N-carboxyethyl chitosan (ACS) was formed by a Micheal reaction. Through the analysisof IR and 1H-NMR spectra, the Micheal reaction was carried out between - NH2 of chitosan and - C= C - of acrylic acid. ACS hydrogel (ACSG) was prepared by cross-linking with glutaraldehyde.ACSG show pH-sensitive swelling behavior, and the smallest swelling rate (SR) of ACSG is in pH5.0buffer solution.With dosage of glutaraldehyde increasing, the SR of ACSG decreased. With graftingdegree (GD) increasing, the SR of ACSG increased first and decreased afterward. Using bovineserum albumin (BSA) as a model medicine, the releasing behaviors of ACSG were investigated invitro. In simulated gastric and intestinal fluid, the ACSG loading BSA (GD=20.45%) has betterreleasing behaviors
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  • 6
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Advanced materials research Vol. 44-46 (June 2008), p. 157-164 
    ISSN: 1662-8985
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: This paper aims to study the uncertainty of the MDOF structural dynamic response, takingnot only the interval characteristics of structural physical parameters and geometric dimension, butalso the interval characteristics of applied load simultaneously . By means of the description of theinterval parameters of uncertain structure with affine forms, the interval structural dynamic equationis studied, and an improved affine arithmetic based on interval division is presented, wherecorrelations between the interval elements in eigenvalue and responses equations are considered,independent uncertain parameters are transformed to affine forms, and the solution of eigenvalue andresponse equations are transformed into the corresponding certain ones. With general affinearithmetic, the eigenvalue of each order and response bounds are determined by searching for themaximum and minimum in the solutions. Finally, some mathematical examples and a furtherengineering application confirm the feasibility and validity of this approach
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  • 7
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 353-358 (Sept. 2007), p. 2239-2243 
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Natural clay minerals are ideal nanofillers for polymer materials and have been attractedtremendous research and development interests in the past decade. The manufacture of claynanofillers relies largely on the exfoliation of clay particle into individual clay platelets. Thus,understanding the interlayer swelling of clay minerals upon the adsorption of surfactants is importantto the fabrication and design of polymer nanocomposites. This paper reports our recent experimentaland theoretical studies on a variety of organoclays that show a linear relationship between the increaseof d-spacing and the mass ratio between organic and clay
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  • 8
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 400-402 (Oct. 2008), p. 275-280 
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Based on the analysis of reinforced concrete beams under biaxial bending, an equivalent cross-section method is proposed to calculate the shear capacity of the beams. According to the two basic equivalence principles, a biaxial flexural beam is changed into a uniaxial flexural member, and the shear strength of biaxial flexural beam is calculated as a uniaxial flexural member. Furthermore, the interrelationships among the equivalent cross-section and the neutral axis inclination as well as the ratio of depth to width of the cross-section are deduced in advance. The ratios of some typical cross-section’s equivalent dimensions to its original ones are pointed also. In order to verify the availability of the equivalent cross-section method, some academic references about the ultimate strength of biaxial flexural beams are consulted in this paper, and the shear capacity computing methods by literatures for uniaxial flexural beams are adopted in the strength calculation of biaxial flexural reinforced concrete simply supported beams with stirrups or without stirrups. The comparison between the calculation results and experimental results shows that the presented equivalent cross-section method is feasible and practical which can be used as a reference in practice design
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  • 9
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 334-335 (Mar. 2007), p. 753-756 
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Polymer nanocomposites are recognized as the next generation of polymer compositesdue to their exceptional properties. Understanding the molecular origin of the reinforcementmechanism is crucial to the development of such promising materials. This paper reports our recentmolecular dynamic study on clay-based polyurethane nanocomposites. The effect of clay plateletson phase separation behavior of polyurethane, at the clay-polyurethane interface, is quantified interms of molecular interactions, structure and dynamics. The results show that the nanoconfinementof polyurethane chains in clay gallery impedes the development of phase separationcommonly observed in bulk polyurethane. The absence of phase separation of intercalatedpolyurethane is believed to be related to the competitive interactions among clay platelet,polyurethane and surfactant
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  • 10
    ISSN: 0730-2312
    Keywords: TGF-α ; antisense oligonucleotides ; head and neck cancer ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Interruption of an autocrine growth pathway involving TGF-α and EGFR may inhibit tumor growth and improve survival in head and neck cancer patients. We previously demonstrated that biopsy specimens and established cell lines from patients with squamous cell carcinoma of the head and neck (SCCHN) overexpress TGF-α and its receptor, epidermal growth factor receptor (EGFR) at both the mRNA and protein levels. Protein localization studies showed that TGF-α and EGFR are produced by the same epithelial cells in tissues from head and neck cancer patients further supporting a role for this ligand-receptor pair in an autocrine growth pathway. To confirm that TGF-α contributes to autocrine growth, we examined the effect of down regulation of TGF-α protein on SCCHN cell proliferation. Treatment of 6 SCCHN cell lines with antisense oligodeoxynucleotides targeting the translation start site of human TGF-α mRNA decreased TGF-α protein production by up to 93% and reduced cell proliferation by a mean of 76.2% compared to a 9.7% reduction with sense oligonucleotide (range P〈0R 〉 = 0.036-0.0001). TGF-α antisense oligonucleotide exposure also decreased TGF-α protein levels in normal oropharyngeal mucosal epithelial cells, however their growth rate was not affected. These findings indicate that TGF-α is participating in an autocrine signaling pathway in transformed, but not in normal mucosal epithelial cells, that promotes proliferation. J. Cell. Biochem. 69:55-62, 1998. © 1998 Wiley-Liss, Inc.
    Additional Material: 4 Ill.
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