Publication Date:
2019
Description:
〈sec〉〈st〉Synopsis〈/st〉〈p〉〈textbox textbox-type="graphic"〉〈p〉〈inline-fig〉〈/inline-fig〉〈/p〉〈/textbox〉〈/p〉
〈p〉As abnormal TGF-β responses are linked to human diseases such as cancer, TGF-β signaling must be tightly regulated. This study uncovers a PTPN3 as regulator of Smurf2 binding to TβRI, a function that is abolished by hepatocarcinoma-associated mutations.〈/p〉
〈p〉 〈l type="unord"〉〈li〉〈p〉PTPN3 potentiates TGF-β signaling independent of its phosphatase activity.〈/p〉〈/li〉
〈li〉〈p〉PTPN3 stabilizes TGF-β type I receptor by inhibiting its interaction with Smurf2.〈/p〉〈/li〉
〈li〉〈p〉L232R mutation associated with intrahepatic cholangiocarcinoma interferes with the TGF-β activatory and tumor suppressive functions of PTPN3.〈/p〉〈/li〉〈/l〉 〈/p〉〈/sec〉
Print ISSN:
0261-4189
Electronic ISSN:
1460-2075
Topics:
Biology
,
Medicine
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