Springer Online Journal Archives 1860-2000
Summary This research was undertaken in order to determine if known biochemical processes involving the conversion of fluoroacetate are reflected morphologically at the electron microscopic level. No changes were observed in the hepatocytes after 2.5 mg/kg of fluoroacetate and sacrifice at 3 hours, but with 5 mg/kg of the drug there was an increase in the amount of agranular endoplasmic reticulum, an aberrant shape of mitochondria, and a disappearance of visible glycogen. One hour after 10, 15, 20, or 30 mg/kg of fluoroacetate the results showed a tremendous increase in the amount of agranular endoplasmic reticulum, an aberration in mitochondrial structure, and a disappearance of the intramitochondrial granules and glycogen. The possible relationship of these changes to fluoroacetate poisoning is discussed.
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