Publication Date:
2014-09-05
Description:
Article Bile acids have been linked to the development of inflammatory bowel diseases, such as colitis. Here the authors show that bile acid levels in mice are controlled by a circular feedback system involving the nuclear receptors PPARα and FXR, and that this system is dysregulated in colitis. Nature Communications doi: 10.1038/ncomms5573 Authors: Xueyan Zhou, Lijuan Cao, Changtao Jiang, Yang Xie, Xuefang Cheng, Kristopher W. Krausz, Yunpeng Qi, Lu Sun, Yatrik M. Shah, Frank J. Gonzalez, Guangji Wang, Haiping Hao
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
Permalink