Publication Date:
2014-09-27
Description:
Article Many tumours originate from cancer stem cells (CSCs), a small population of cells that display stem cell properties. Here Kanda and colleagues show that the lipid mediator, sphingosine-1 phosphate (S1P), enhances expansion of ALDH-positive CSCs via S1P receptor 3 (S1PR3) and subsequent Notch activation, providing a rationale for targeting S1PR3 in cancer. Nature Communications doi: 10.1038/ncomms5806 Authors: Naoya Hirata, Shigeru Yamada, Takuji Shoda, Masaaki Kurihara, Yuko Sekino, Yasunari Kanda
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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