ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    Emergence of topological bands on the surface of ZrSnTe crystal (2016)
    American Physical Society (APS)
    Details
    Publication Date: 2016-06-16
    Description: Author(s): R. Lou, J.-Z. Ma, Q.-N. Xu, B.-B. Fu, L.-Y. Kong, Y.-G. Shi, P. Richard, H.-M. Weng, Z. Fang, S.-S. Sun, Q. Wang, H.-C. Lei, T. Qian, H. Ding, and S.-C. Wang By using angle-resolved photoemission spectroscopy combined with first-principles calculations, we reveal that the topmost unit cell of ZrSnTe crystal hosts two-dimensional (2D) electronic bands of the topological insulator (TI) state, although such a TI state is defined with a curved Fermi level in… [Phys. Rev. B 93, 241104(R)] Published Wed Jun 15, 2016
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    Isoform-specific functions of GalNAc-transferases [Cell Biology] (2012)
    National Academy of Sciences
    Details
    Publication Date: 2012-06-20
    Description: Our knowledge of the O-glycoproteome [N-acetylgalactosamine (GalNAc) type] is highly limited. The O-glycoproteome is differentially regulated in cells by dynamic expression of a subset of 20 polypeptide GalNAc-transferases (GalNAc-Ts), and methods to identify important functions of individual GalNAc-Ts are largely unavailable. We recently introduced SimpleCells, i.e., human cell lines made deficient in O-glycan extension by zinc finger nuclease targeting of a key gene in O-glycan elongation (Cosmc), which allows for proteome-wide discovery of O-glycoproteins. Here we have extended the SimpleCell concept to include proteome-wide discovery of unique functions of individual GalNAc-Ts. We used the GalNAc-T2 isoform implicated in dyslipidemia and the human HepG2 liver cell line to demonstrate unique functions of this isoform. We confirm that GalNAc-T2–directed site-specific O-glycosylation inhibits proprotein activation of the lipase inhibitor ANGPTL3 in HepG2 cells and further identify eight O-glycoproteins exclusively glycosylated by T2 of which one, ApoC-III, is implicated in dyslipidemia. Our study supports an essential role for GalNAc-T2 in lipid metabolism, provides serum biomarkers for GalNAc-T2 enzyme function, and validates the use of GALNT gene targeting with SimpleCells for broad discovery of disease-causing deficiencies in O-glycosylation. The presented glycoengineering strategy opens the way for proteome-wide discovery of functions of GalNAc-T isoforms and their role in congenital diseases and disorders.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    Adapting to climate change through urban green infrastructure (2012)
    Springer Nature
    Details
    Publication Date: 2012-09-28
    Description: Nature Climate Change 2 704 doi: 10.1038/nclimate1685
    Print ISSN: 1758-678X
    Electronic ISSN: 1758-6798
    Topics: Geosciences
    Published by Springer Nature
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    facet.materialart.
    Unknown
    Identification and calculation of transfer overpressure in the northern Qaidam Basin, northwest China (2016)
    American Association of Petroleum Geologists (AAPG)
    Details
    Publication Date: 2016-01-27
    Description: The origin of the overpressure in the northern Qaidam Basin has not been clearly understood, which has caused some difficulties in hydrocarbon exploration. Using a compaction study, we applied a modified acoustic-velocity and effective-stress diagram to identify the overpressure transfer in the study area. This phenomenon has not been discussed in previous studies. For the present study, we approximately calculated the magnitude of the transfer overpressure and analyzed the cause of the overpressured aquifer at the crest of the anticline in the study area. Our study indicates that the effect of overpressure transfer is very distinct, and the largest contribution to the total overpressure is 57%. The main media of overpressure transfer include vertical faults and lateral conducting layers. The vertical faults can connect deep overpressured strata, and the lateral conducting layers can connect overpressured strata at the top and wing of the anticline. During anticline formation, the crest fractures, and then the overpressured water in the anticline wing flows into the fractured crest and forms the overpressure compartment that prevents the charging of deeper natural gas.
    Print ISSN: 0149-1423
    Electronic ISSN: 0149-1423
    Topics: Geosciences
    Published by American Association of Petroleum Geologists (AAPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 5
    facet.materialart.
    Unknown
    Impact of Social Network and Business Model on Innovation Diffusion of Electric Vehicles in China (2014)
    Hindawi
    Details
    Publication Date: 2014-03-27
    Description: The diffusion of electric vehicles (EVs) involves not only the technological development but also the construction of complex social networks. This paper uses the theory of network control to analyze the influence of network forms on EV diffusion in China, especially focusing on the building of EV business models (BMs) and the resulting effects and control on the diffusion of EVs. The Bass model is adopted to forecast the diffusion process of EVs and genetic algorithm is used to estimate the parameters based on the diffusion data of Hybrid Electric Vehicle (HEV) in the United States and Japan. Two different social network forms and BMs are selected, that is, battery leasing model and vehicle purchasing model, to analyze how different network forms may influence the innovation coefficient and imitation coefficient in the Bass model, which will in turn result in different diffusion results. Thereby, we can find the appropriate network forms and BMs for EVs which is suitable to the local market conditions.
    Print ISSN: 1024-123X
    Electronic ISSN: 1563-5147
    Topics: Mathematics , Technology
    Published by Hindawi
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 6
    facet.materialart.
    Unknown
    An Improved Car-Following Model in Vehicle Networking Based on Network Control (2014)
    Hindawi
    Details
    Publication Date: 2014-03-25
    Description: Vehicle networking is a system to realize information interoperability between vehicles and people, vehicles and roads, vehicles and vehicles, and cars and transport facilities, through the network information exchange, in order to achieve the effective monitoring of the vehicle and traffic flow. Realizing information interoperability between vehicles and vehicles, which can affect the traffic flow, is an important application of network control system (NCS). In this paper, a car-following model using vehicle networking theory is established, based on network control principle. The car-following model, which is an improvement of the traditional traffic model, describes the traffic in vehicle networking condition. The impact that vehicle networking has on the traffic flow is quantitatively assessed in a particular scene of one-way, no lane changing highway. The examples show that the capacity of the road is effectively enhanced by using vehicle networking.
    Print ISSN: 1024-123X
    Electronic ISSN: 1563-5147
    Topics: Mathematics , Technology
    Published by Hindawi
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 7
    facet.materialart.
    Unknown
    The HECTD3 E3 ubiquitin ligase facilitates cancer cell survival by promoting K63-linked polyubiquitination of caspase-8 (2013)
    Springer Nature
    Details
    Publication Date: 2013-11-29
    Description: The HECTD3 E3 ubiquitin ligase facilitates cancer cell survival by promoting K63-linked polyubiquitination of caspase-8 Cell Death and Disease 4, e935 (November 2013). doi:10.1038/cddis.2013.464 Authors: Y Li, Y Kong, Z Zhou, H Chen, Z Wang, Y-C Hsieh, D Zhao, X Zhi, J Huang, J Zhang, H Li & C Chen
    Keywords: ubiquitinationapoptosisbreast cancerHECTD3caspase-8
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Springer Nature
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 8
    facet.materialart.
    Unknown
    A support vector machine to search for metal-poor galaxies (2014)
    Oxford University Press
    Details
    Publication Date: 2014-08-09
    Description: To develop a fast and reliable method for selecting metal-poor galaxies (MPGs), especially in large surveys and huge data bases, a support vector machine ( svm ) supervized learning algorithms is applied to a sample of star-forming galaxies from the Sloan Digital Sky Survey data release 9 provided by the Max Planck Institute and the Johns Hopkins University ( http://www.sdss3.org/dr9/spectro/spectroaccess.php ). A two-step approach is adopted: (i) the svm must be trained with a subset of objects that are known to be either MPGs or metal-rich galaxies (MRGs), treating the strong emission line flux measurements as input feature vectors in n -dimensional space, where n is the number of strong emission line flux ratios. (ii) After training on a sample of star-forming galaxies, the remaining galaxies are classified in the automatic test analysis as either MPGs or MRGs using a 10-fold cross-validation technique. For target selection, we have achieved an acquisition accuracy for MPGs of ~96 and ~95 per cent for an MPG threshold of 12 + log(O/H) = 8.00 and 12 + log(O/H) = 8.39, respectively. Running the code takes minutes in most cases under the matlab 2013a software environment. The code in the Letter is available on the web ( http://fshi5388.blog.163.com ). The svm method can easily be extended to any MPGs target selection task and can be regarded as an efficient classification method particularly suitable for modern large surveys.
    Print ISSN: 1745-3925
    Electronic ISSN: 1745-3933
    Topics: Physics
    Published by Oxford University Press
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 9
    facet.materialart.
    Unknown
    Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-09-22
    Description: The molecular adapter Fyb/Slap regulates signaling downstream of the T cell receptor (TCR), but whether it plays a positive or negative role is controversial. We demonstrate that Fyb/Slap-deficient T cells exhibit defective proliferation and cytokine production in response to TCR stimulation. Fyb/Slap is also required in vivo for T cell-dependent immune responses. Functionally, Fyb/Slap has no apparent role in the activation of known TCR signaling pathways, F-actin polymerization, or TCR clustering. Rather, Fyb/Slap regulates TCR-induced integrin clustering and adhesion. Thus, Fyb/Slap is the first molecular adapter to be identified that couples TCR stimulation to the avidity modulation of integrins governing T cell adhesion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Griffiths, E K -- Krawczyk, C -- Kong, Y Y -- Raab, M -- Hyduk, S J -- Bouchard, D -- Chan, V S -- Kozieradzki, I -- Oliveira-Dos-Santos, A J -- Wakeham, A -- Ohashi, P S -- Cybulsky, M I -- Rudd, C E -- Penninger, J M -- New York, N.Y. -- Science. 2001 Sep 21;293(5538):2260-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Amgen Institute, 620 University Avenue, Toronto, Ontario, Canada M5G 2C1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11567140" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/metabolism ; *Adaptor Proteins, Signal Transducing ; Animals ; Antigens, CD/metabolism ; Antigens, CD3/metabolism ; Antigens, Differentiation, T-Lymphocyte/metabolism ; B-Lymphocytes/immunology ; Carrier Proteins/genetics/*physiology ; Cell Adhesion ; Cell Adhesion Molecules/metabolism ; Chimera ; Gene Targeting ; Humans ; Immunization ; Immunoglobulin G/biosynthesis ; Integrins/*metabolism ; Intercellular Adhesion Molecule-1/metabolism ; Interferon-gamma/biosynthesis ; Interleukin-2/biosynthesis/pharmacology ; Lectins, C-Type ; *Lymphocyte Activation ; Lymphocyte Function-Associated Antigen-1/metabolism ; Mice ; Phosphoproteins/genetics/*physiology ; Receptors, Antigen, T-Cell/immunology/metabolism ; Receptors, Interleukin-2/metabolism ; Recombinant Proteins/metabolism ; Signal Transduction ; T-Lymphocytes/immunology/metabolism/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 10
    facet.materialart.
    Unknown
    DNA damage-induced activation of p53 by the checkpoint kinase Chk2 (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-03-10
    Description: Chk2 is a protein kinase that is activated in response to DNA damage and may regulate cell cycle arrest. We generated Chk2-deficient mouse cells by gene targeting. Chk2-/- embryonic stem cells failed to maintain gamma-irradiation-induced arrest in the G2 phase of the cell cycle. Chk2-/- thymocytes were resistant to DNA damage-induced apoptosis. Chk2-/- cells were defective for p53 stabilization and for induction of p53-dependent transcripts such as p21 in response to gamma irradiation. Reintroduction of the Chk2 gene restored p53-dependent transcription in response to gamma irradiation. Chk2 directly phosphorylated p53 on serine 20, which is known to interfere with Mdm2 binding. This provides a mechanism for increased stability of p53 by prevention of ubiquitination in response to DNA damage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hirao, A -- Kong, Y Y -- Matsuoka, S -- Wakeham, A -- Ruland, J -- Yoshida, H -- Liu, D -- Elledge, S J -- Mak, T W -- GM44664/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2000 Mar 10;287(5459):1824-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Amgen Institute, Ontario Cancer Institute, and Departments of Medical Biophysics and Immunology, University of Toronto, 620 University Avenue, Suite 706, Toronto, Ontario, M5G 2C1, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10710310" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis ; Ataxia Telangiectasia Mutated Proteins ; Cell Cycle Proteins ; Checkpoint Kinase 2 ; *DNA Damage ; DNA-Binding Proteins ; G1 Phase ; G2 Phase ; Gamma Rays ; Gene Expression Regulation ; Gene Targeting ; Genes, Tumor Suppressor ; Genes, p53 ; Humans ; *Interphase ; Mice ; *Nuclear Proteins ; Phosphorylation ; Phosphoserine/metabolism ; *Protein Kinases ; Protein-Serine-Threonine Kinases/*metabolism ; Proto-Oncogene Proteins/metabolism ; Proto-Oncogene Proteins c-mdm2 ; Stem Cells/cytology/metabolism ; T-Lymphocytes/cytology ; Transcription, Genetic ; Tumor Suppressor Protein p53/*metabolism ; Tumor Suppressor Proteins
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...