Publication Date:
2004-10-02
Description:
Nodal proteins, members of the transforming growth factor-beta (TGFbeta) superfamily, have been identified as key endogenous mesoderm inducers in vertebrates. Precise control of Nodal signaling is essential for normal development of embryos. Here, we report that zebrafish dapper2 (dpr2) is expressed in mesoderm precursors during early embryogenesis and is positively regulated by Nodal signals. In vivo functional studies in zebrafish suggest that Dpr2 suppresses mesoderm induction activities of Nodal signaling. Dpr2 is localized in late endosomes, binds to the TGFbeta receptors ALK5 and ALK4, and accelerates lysosomal degradation of these receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhang, Lixia -- Zhou, Hu -- Su, Ying -- Sun, Zhihui -- Zhang, Haiwen -- Zhang, Long -- Zhang, Yu -- Ning, Yuanheng -- Chen, Ye-Guang -- Meng, Anming -- New York, N.Y. -- Science. 2004 Oct 1;306(5693):114-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Developmental Biology, Ministry of Education (MOE), Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15459392" target="_blank"〉PubMed〈/a〉
Keywords:
Activin Receptors, Type I/*metabolism
;
Amino Acid Sequence
;
Animals
;
Cell Line
;
Embryo, Nonmammalian/embryology/*metabolism
;
*Embryonic Induction
;
Endosomes/metabolism
;
Fluorescent Antibody Technique
;
Gene Expression Profiling
;
Gene Expression Regulation, Developmental
;
Humans
;
In Situ Hybridization
;
Intracellular Signaling Peptides and Proteins
;
Lysosomes/metabolism
;
Mesoderm/*physiology
;
Molecular Sequence Data
;
Mutation
;
Nodal Signaling Ligands
;
Oligonucleotides, Antisense
;
Protein-Serine-Threonine Kinases
;
Proteins/metabolism
;
Receptors, Transforming Growth Factor beta/*metabolism
;
Signal Transduction
;
Transforming Growth Factor beta/genetics/metabolism
;
Zebrafish/*embryology/genetics/metabolism
;
Zebrafish Proteins/chemistry/genetics/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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